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- W1963709620 endingPage "370" @default.
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- W1963709620 abstract "Antibiotics have significantly improved our living environments. However, overuse of antibiotics has led to the emergence of multi-drug resistant microorganisms, and the subsequent constant demand for the exploration of novel antibiotics. To this end, antimicrobial peptides (AMPs) have attracted much attention as a novel class of antibiotics. AMPs have strong antimicrobial activity against a wide-range of species, including gram-positive and gram-negative bacteria, fungi, and viruses. In addition, they are also effective against pathogenic organisms that are resistant to conventional drugs. Despite their great potential, the hemolytic activity and a highly broad spectrum of activity of AMPs dictate the need for amendments to develop safe pharmaceuticals. The human body contains commensal microflora as an integral part of complex mucosal surfaces that offers protection against pathogenic organisms. Administration of antibiotics with broad spectra of activity disrupts the indigenous microflora and increases the risks of diarrhea and other fatal infections. Therefore, it is difficult, but vital, to develop treatments capable of rapidly eliminating pathogenic organisms while maintaining the commensal microbiota. As such, novel pharmaceuticals, safe designer AMPs have been heavily researched. In this article, we review recent attempts to spatially and temporally regulate AMPs to enhance the quality-of-life of patients." @default.
- W1963709620 created "2016-06-24" @default.
- W1963709620 creator A5063620609 @default.
- W1963709620 creator A5066036279 @default.
- W1963709620 creator A5074040545 @default.
- W1963709620 date "2012-10-01" @default.
- W1963709620 modified "2023-10-12" @default.
- W1963709620 title "Next generation of antimicrobial peptides as molecular targeted medicines" @default.
- W1963709620 cites W1501628121 @default.
- W1963709620 cites W1557782384 @default.
- W1963709620 cites W1567942330 @default.
- W1963709620 cites W1584024908 @default.
- W1963709620 cites W1587430592 @default.
- W1963709620 cites W16631805 @default.
- W1963709620 cites W1808348270 @default.
- W1963709620 cites W1833440586 @default.
- W1963709620 cites W1836919226 @default.
- W1963709620 cites W1931276869 @default.
- W1963709620 cites W1954606945 @default.
- W1963709620 cites W1970621669 @default.
- W1963709620 cites W1971756197 @default.
- W1963709620 cites W1973113582 @default.
- W1963709620 cites W197620025 @default.
- W1963709620 cites W1976509321 @default.
- W1963709620 cites W1977165873 @default.
- W1963709620 cites W1981388076 @default.
- W1963709620 cites W1982240222 @default.
- W1963709620 cites W1982832550 @default.
- W1963709620 cites W1989998611 @default.
- W1963709620 cites W1993674860 @default.
- W1963709620 cites W1993791807 @default.
- W1963709620 cites W1997152791 @default.
- W1963709620 cites W1997537738 @default.
- W1963709620 cites W1999150257 @default.
- W1963709620 cites W2001646764 @default.
- W1963709620 cites W2008541744 @default.
- W1963709620 cites W2011417528 @default.
- W1963709620 cites W2013674343 @default.
- W1963709620 cites W2018547804 @default.
- W1963709620 cites W2020137152 @default.
- W1963709620 cites W2020755269 @default.
- W1963709620 cites W2023192368 @default.
- W1963709620 cites W2023938985 @default.
- W1963709620 cites W2029073712 @default.
- W1963709620 cites W2038014125 @default.
- W1963709620 cites W2045362817 @default.
- W1963709620 cites W2047599457 @default.
- W1963709620 cites W2053416730 @default.
- W1963709620 cites W2054184600 @default.
- W1963709620 cites W2054602599 @default.
- W1963709620 cites W2054901102 @default.
- W1963709620 cites W2056263305 @default.
- W1963709620 cites W2057198053 @default.
- W1963709620 cites W2059884070 @default.
- W1963709620 cites W2063411604 @default.
- W1963709620 cites W2070762622 @default.
- W1963709620 cites W2072250256 @default.
- W1963709620 cites W2074225999 @default.
- W1963709620 cites W2079468421 @default.
- W1963709620 cites W2082816719 @default.
- W1963709620 cites W2083183071 @default.
- W1963709620 cites W2084845164 @default.
- W1963709620 cites W2095855980 @default.
- W1963709620 cites W2097098774 @default.
- W1963709620 cites W2097832355 @default.
- W1963709620 cites W2098607423 @default.
- W1963709620 cites W2101382753 @default.
- W1963709620 cites W2102672963 @default.
- W1963709620 cites W2108226494 @default.
- W1963709620 cites W2112340256 @default.
- W1963709620 cites W2115830594 @default.
- W1963709620 cites W2121748291 @default.
- W1963709620 cites W2123172081 @default.
- W1963709620 cites W2125644936 @default.
- W1963709620 cites W2127805721 @default.
- W1963709620 cites W2129059285 @default.
- W1963709620 cites W2131186249 @default.
- W1963709620 cites W2134573232 @default.
- W1963709620 cites W2137832760 @default.
- W1963709620 cites W2139703305 @default.
- W1963709620 cites W2140151651 @default.
- W1963709620 cites W2140327701 @default.
- W1963709620 cites W2140472579 @default.
- W1963709620 cites W2142827309 @default.
- W1963709620 cites W2145336165 @default.
- W1963709620 cites W2145594148 @default.
- W1963709620 cites W2148067829 @default.
- W1963709620 cites W2151958462 @default.
- W1963709620 cites W2152963387 @default.
- W1963709620 cites W2159861471 @default.
- W1963709620 cites W2163665267 @default.
- W1963709620 cites W4211190410 @default.
- W1963709620 cites W4231311323 @default.
- W1963709620 cites W4248430793 @default.
- W1963709620 doi "https://doi.org/10.1016/j.jbiosc.2012.05.001" @default.
- W1963709620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22658802" @default.
- W1963709620 hasPublicationYear "2012" @default.
- W1963709620 type Work @default.