FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963713462> ?p ?o ?g. }

• W1963713462 endingPage "1113" @default.
• W1963713462 startingPage "1106" @default.
• W1963713462 abstract "Temporal lobe epilepsy patients remain refractory to available anti-epileptic drugs in 30% of cases, indicating a need for novel therapeutic strategies. In this context, glial cell line–derived neurotrophic factor (GDNF) emerges as a possible new agent for epilepsy treatment. However, a limited number of studies, use of different epilepsy models, and different methods of GDNF delivery preclude understanding of the mechanisms for the seizure-suppressant action of GDNF. Here we show that recombinant adeno-associated viral (rAAV) vector–based GDNF overexpression in the rat hippocampus suppresses seizures in two models of temporal lobe epilepsy. First, when rAAV-GDNF was injected before hippocampal kindling, the number of generalized seizures decreased, and the prolongation of behavioral convulsions in fully kindled animals was prevented. Second, injection of rAAV-GDNF after kindling increased the seizure induction threshold. Third, rAAV-GDNF decreased the frequency of generalized seizures during the self-sustained phase of status epilepticus. Our data demonstrate the complexity of mechanisms and the beneficial action of GDNF in epilepsy. Furthermore, we show that ectopic rAAV-mediated GDNF gene expression in the seizure focus is a feasible way to mitigate seizures and provides proof of principle that the neurotrophic factor–based gene therapy approach has the potential to be developed as alternative strategy for epilepsy treatment. Temporal lobe epilepsy patients remain refractory to available anti-epileptic drugs in 30% of cases, indicating a need for novel therapeutic strategies. In this context, glial cell line–derived neurotrophic factor (GDNF) emerges as a possible new agent for epilepsy treatment. However, a limited number of studies, use of different epilepsy models, and different methods of GDNF delivery preclude understanding of the mechanisms for the seizure-suppressant action of GDNF. Here we show that recombinant adeno-associated viral (rAAV) vector–based GDNF overexpression in the rat hippocampus suppresses seizures in two models of temporal lobe epilepsy. First, when rAAV-GDNF was injected before hippocampal kindling, the number of generalized seizures decreased, and the prolongation of behavioral convulsions in fully kindled animals was prevented. Second, injection of rAAV-GDNF after kindling increased the seizure induction threshold. Third, rAAV-GDNF decreased the frequency of generalized seizures during the self-sustained phase of status epilepticus. Our data demonstrate the complexity of mechanisms and the beneficial action of GDNF in epilepsy. Furthermore, we show that ectopic rAAV-mediated GDNF gene expression in the seizure focus is a feasible way to mitigate seizures and provides proof of principle that the neurotrophic factor–based gene therapy approach has the potential to be developed as alternative strategy for epilepsy treatment." @default.
• W1963713462 created "2016-06-24" @default.
• W1963713462 creator A5037646469 @default.
• W1963713462 creator A5046235279 @default.
• W1963713462 creator A5073732733 @default.
• W1963713462 creator A5083016310 @default.
• W1963713462 date "2007-06-01" @default.
• W1963713462 modified "2023-10-07" @default.
• W1963713462 title "Seizure Suppression by GDNF Gene Therapy in Animal Models of Epilepsy" @default.
• W1963713462 cites W1861338253 @default.
• W1963713462 cites W1970914521 @default.
• W1963713462 cites W1971163805 @default.
• W1963713462 cites W1972605667 @default.
• W1963713462 cites W1983973735 @default.
• W1963713462 cites W1984253712 @default.
• W1963713462 cites W1987208997 @default.
• W1963713462 cites W1987904402 @default.
• W1963713462 cites W1989400013 @default.
• W1963713462 cites W1994452959 @default.
• W1963713462 cites W1996591930 @default.
• W1963713462 cites W1998885927 @default.
• W1963713462 cites W2003490873 @default.
• W1963713462 cites W2006127601 @default.
• W1963713462 cites W2010186484 @default.
• W1963713462 cites W2013137971 @default.
• W1963713462 cites W2013436215 @default.
• W1963713462 cites W2014078232 @default.
• W1963713462 cites W2015030562 @default.
• W1963713462 cites W2028620081 @default.
• W1963713462 cites W2040317782 @default.
• W1963713462 cites W2040384956 @default.
• W1963713462 cites W2040910263 @default.
• W1963713462 cites W2045424008 @default.
• W1963713462 cites W2054810445 @default.
• W1963713462 cites W2058171345 @default.
• W1963713462 cites W2061768568 @default.
• W1963713462 cites W2064027677 @default.
• W1963713462 cites W2069866761 @default.
• W1963713462 cites W2074698464 @default.
• W1963713462 cites W2079738825 @default.
• W1963713462 cites W2088745158 @default.
• W1963713462 cites W2093320992 @default.
• W1963713462 cites W2094388056 @default.
• W1963713462 cites W2103946141 @default.
• W1963713462 cites W2106657856 @default.
• W1963713462 cites W2111141909 @default.
• W1963713462 cites W2116944580 @default.
• W1963713462 cites W2118016417 @default.
• W1963713462 cites W2124696700 @default.
• W1963713462 cites W2124748602 @default.
• W1963713462 cites W2139661803 @default.
• W1963713462 cites W2150857721 @default.
• W1963713462 cites W2150936467 @default.
• W1963713462 cites W2158496649 @default.
• W1963713462 cites W2335402323 @default.
• W1963713462 cites W4246283964 @default.
• W1963713462 doi "https://doi.org/10.1038/sj.mt.6300148" @default.
• W1963713462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17387333" @default.
• W1963713462 hasPublicationYear "2007" @default.
• W1963713462 type Work @default.
• W1963713462 sameAs 1963713462 @default.
• W1963713462 citedByCount "85" @default.
• W1963713462 countsByYear W19637134622012 @default.
• W1963713462 countsByYear W19637134622013 @default.
• W1963713462 countsByYear W19637134622014 @default.
• W1963713462 countsByYear W19637134622015 @default.
• W1963713462 countsByYear W19637134622016 @default.
• W1963713462 countsByYear W19637134622017 @default.
• W1963713462 countsByYear W19637134622018 @default.
• W1963713462 countsByYear W19637134622019 @default.
• W1963713462 countsByYear W19637134622020 @default.
• W1963713462 countsByYear W19637134622021 @default.
• W1963713462 countsByYear W19637134622022 @default.
• W1963713462 countsByYear W19637134622023 @default.
• W1963713462 crossrefType "journal-article" @default.
• W1963713462 hasAuthorship W1963713462A5037646469 @default.
• W1963713462 hasAuthorship W1963713462A5046235279 @default.
• W1963713462 hasAuthorship W1963713462A5073732733 @default.
• W1963713462 hasAuthorship W1963713462A5083016310 @default.
• W1963713462 hasBestOaLocation W19637134621 @default.
• W1963713462 hasConcept C100691959 @default.
• W1963713462 hasConcept C126322002 @default.
• W1963713462 hasConcept C148762608 @default.
• W1963713462 hasConcept C151730666 @default.
• W1963713462 hasConcept C15744967 @default.
• W1963713462 hasConcept C160539049 @default.
• W1963713462 hasConcept C169760540 @default.
• W1963713462 hasConcept C170493617 @default.
• W1963713462 hasConcept C185856081 @default.
• W1963713462 hasConcept C2777341932 @default.
• W1963713462 hasConcept C2778186239 @default.
• W1963713462 hasConcept C2778302826 @default.
• W1963713462 hasConcept C2779343474 @default.
• W1963713462 hasConcept C2781161787 @default.
• W1963713462 hasConcept C71924100 @default.
• W1963713462 hasConcept C86803240 @default.
• W1963713462 hasConcept C98274493 @default.
• W1963713462 hasConceptScore W1963713462C100691959 @default.

• next