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• W1963726248 abstract "Previous work has shown that injection of the 5-hydroxytryptamine (5-HT)1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) into the midbrain raphe nuclei activates somatodendritic 5-HT autoreceptors leading to decreased 5-HT synthesis and release in terminal forebrain regions and an increase in feeding behaviour. Since 5-HT is belived to function antagonistically with norepinephrine (NE) in the hypothalamic paraventricular nucleus (PVN) to control feeding, it has been proposed that 8-OH-DPAT elecits food intake by removing the inhibitory influence of 5-HT over PVN α2-adrenergic feeding mechanisms. This hypothesis was tested by examining the ability of PVN injection of the α2-adrenoceptor antagonist idazoxan (IDAZ) to attenuate the feeding stimulant action induced by raphe injection of 8-OH-DPAT. In the first series of experiments the dose-response effects of dorsal and median raphe injection of 8-OH-DPAT in addition to PVN NE on feeding were examined. Injection of NE (5–40 nmol) and 8-OH-DPAT (0.4–1.6 nmol) both elicited reliable dose-dependent increases in 1 h food intake compared to saline control. Similar doses of 8-OH-DPAT injected into the PVN failed to alter baseline feeding. A second series of experiments examined the effects of IDAZ on 8-OH-DPAT and NE-stimulated food intake in rats implanted with dorsal or median raphe cannulae as well as cannulae aimed at the PVN. Although PVN injection of IDAZ (12.5–50 nmol) effectively attenuated PVN NE (20 nmol) feeding, it did not affect feeding resulting from dorsal raphe or median raphe injection of 8-OH-DPAT (0.8 nmol). The inability of IDAZ to block 8-OH-DPAT-induced food intake suggest that feeding elicited by this 5-HT1A agonist is not mediated by PVN α2-adrenergic systems." @default.
• W1963726248 created "2016-06-24" @default.
• W1963726248 creator A5042939855 @default.
• W1963726248 creator A5059110835 @default.
• W1963726248 date "1993-11-01" @default.
• W1963726248 modified "2023-09-25" @default.
• W1963726248 title "Paraventricular nucleus injections of idazoxan block feeding induced by paraventricular nucleus norepinephrine but not intra-raphe 8-hydroxy-2-(di-n-propylamino) tetralin" @default.
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• W1963726248 doi "https://doi.org/10.1016/0006-8993(93)90759-g" @default.
• W1963726248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7904886" @default.
• W1963726248 hasPublicationYear "1993" @default.
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