FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963727587> ?p ?o ?g. }

• W1963727587 endingPage "4343" @default.
• W1963727587 startingPage "4329" @default.
• W1963727587 abstract "Aberrant regulation of the erythroblastosis oncogene B (ErbB) family of receptor tyrosine kinases (RTKs) and their ligands is common in human cancers. ErbB3 is required in luminal mammary epithelial cells (MECs) for growth and survival. Since breast cancer phenotypes may reflect biological traits of the MECs from which they originate, we tested the hypothesis that ErbB3 drives luminal breast cancer growth. We found higher ERBB3 expression and more frequent ERBB3 gene copy gains in luminal A/B breast cancers compared with other breast cancer subtypes. In cell culture, ErbB3 increased growth of luminal breast cancer cells. Targeted depletion of ErbB3 with an anti-ErbB3 antibody decreased 3D colony growth, increased apoptosis, and decreased tumor growth in vivo. Treatment of clinical breast tumors with the antiendocrine drug fulvestrant resulted in increased ErbB3 expression and PI3K/mTOR signaling. Depletion of ErbB3 in fulvestrant-treated tumor cells reduced PI3K/mTOR signaling, thus decreasing tumor cell survival and tumor growth. Fulvestrant treatment increased phosphorylation of all ErbB family RTKs; however, phospho-RTK upregulation was not seen in tumors treated with both fulvestrant and anti-ErbB3. These data indicate that upregulation of ErbB3 in luminal breast cancer cells promotes growth, survival, and resistance to fulvestrant, thus suggesting ErbB3 as a target for breast cancer treatment." @default.
• W1963727587 created "2016-06-24" @default.
• W1963727587 creator A5006317694 @default.
• W1963727587 creator A5011680064 @default.
• W1963727587 creator A5021488024 @default.
• W1963727587 creator A5026053999 @default.
• W1963727587 creator A5037252693 @default.
• W1963727587 creator A5037437868 @default.
• W1963727587 creator A5037945408 @default.
• W1963727587 creator A5041028923 @default.
• W1963727587 creator A5043946489 @default.
• W1963727587 creator A5050114109 @default.
• W1963727587 creator A5063184551 @default.
• W1963727587 creator A5070908762 @default.
• W1963727587 creator A5088553415 @default.
• W1963727587 creator A5089113899 @default.
• W1963727587 creator A5089266146 @default.
• W1963727587 creator A5089513581 @default.
• W1963727587 date "2013-09-03" @default.
• W1963727587 modified "2023-10-14" @default.
• W1963727587 title "ErbB3 downregulation enhances luminal breast tumor response to antiestrogens" @default.
• W1963727587 cites W1488828742 @default.
• W1963727587 cites W1538689436 @default.
• W1963727587 cites W1582187753 @default.
• W1963727587 cites W1607267312 @default.
• W1963727587 cites W1910394875 @default.
• W1963727587 cites W1963533510 @default.
• W1963727587 cites W1978421730 @default.
• W1963727587 cites W1991858733 @default.
• W1963727587 cites W1992916424 @default.
• W1963727587 cites W1995242599 @default.
• W1963727587 cites W1996735618 @default.
• W1963727587 cites W1997579117 @default.
• W1963727587 cites W1998971866 @default.
• W1963727587 cites W2006910575 @default.
• W1963727587 cites W2007245209 @default.
• W1963727587 cites W2043409879 @default.
• W1963727587 cites W2069526613 @default.
• W1963727587 cites W2073302269 @default.
• W1963727587 cites W2090855460 @default.
• W1963727587 cites W2096283457 @default.
• W1963727587 cites W2101306957 @default.
• W1963727587 cites W2106292881 @default.
• W1963727587 cites W2112369586 @default.
• W1963727587 cites W2113234525 @default.
• W1963727587 cites W2113561732 @default.
• W1963727587 cites W2116201594 @default.
• W1963727587 cites W2123303833 @default.
• W1963727587 cites W2125420434 @default.
• W1963727587 cites W2128985829 @default.
• W1963727587 cites W2131994307 @default.
• W1963727587 cites W2132619562 @default.
• W1963727587 cites W2135548733 @default.
• W1963727587 cites W2137201767 @default.
• W1963727587 cites W2139444209 @default.
• W1963727587 cites W2146284460 @default.
• W1963727587 cites W2149441684 @default.
• W1963727587 cites W2156711378 @default.
• W1963727587 cites W2157840751 @default.
• W1963727587 cites W2159121906 @default.
• W1963727587 cites W2160450758 @default.
• W1963727587 cites W2163011383 @default.
• W1963727587 cites W2164541907 @default.
• W1963727587 cites W2165003903 @default.
• W1963727587 cites W2166609912 @default.
• W1963727587 cites W2167188058 @default.
• W1963727587 cites W2216718464 @default.
• W1963727587 cites W2329126676 @default.
• W1963727587 cites W4247175251 @default.
• W1963727587 doi "https://doi.org/10.1172/jci66764" @default.
• W1963727587 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3784526" @default.
• W1963727587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23999432" @default.
• W1963727587 hasPublicationYear "2013" @default.
• W1963727587 type Work @default.
• W1963727587 sameAs 1963727587 @default.
• W1963727587 citedByCount "50" @default.
• W1963727587 countsByYear W19637275872013 @default.
• W1963727587 countsByYear W19637275872014 @default.
• W1963727587 countsByYear W19637275872015 @default.
• W1963727587 countsByYear W19637275872016 @default.
• W1963727587 countsByYear W19637275872017 @default.
• W1963727587 countsByYear W19637275872018 @default.
• W1963727587 countsByYear W19637275872019 @default.
• W1963727587 countsByYear W19637275872020 @default.
• W1963727587 countsByYear W19637275872021 @default.
• W1963727587 countsByYear W19637275872022 @default.
• W1963727587 crossrefType "journal-article" @default.
• W1963727587 hasAuthorship W1963727587A5006317694 @default.
• W1963727587 hasAuthorship W1963727587A5011680064 @default.
• W1963727587 hasAuthorship W1963727587A5021488024 @default.
• W1963727587 hasAuthorship W1963727587A5026053999 @default.
• W1963727587 hasAuthorship W1963727587A5037252693 @default.
• W1963727587 hasAuthorship W1963727587A5037437868 @default.
• W1963727587 hasAuthorship W1963727587A5037945408 @default.
• W1963727587 hasAuthorship W1963727587A5041028923 @default.
• W1963727587 hasAuthorship W1963727587A5043946489 @default.
• W1963727587 hasAuthorship W1963727587A5050114109 @default.
• W1963727587 hasAuthorship W1963727587A5063184551 @default.

• next