FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963731407> ?p ?o ?g. }

• W1963731407 endingPage "280" @default.
• W1963731407 startingPage "270" @default.
• W1963731407 abstract "The pharmacokinetic (PK) parameters of artesunate, artemether and their metabolites dihydroartemisinin (DHA) and dihydroartemisinin-glucuronide (DHA-glucuronide) were determined in sheep naturally infected with Fasciola hepatica. Sheep were treated either with artesunate (intramuscular (i.m.): 40 and 60 mg/kg) or artemether (i.m.: 40 and 160 mg/kg; oral: 80 mg/kg). Blood samples were withdrawn at selected time points post treatment and the artemisinins were quantified in plasma by liquid chromatography and tandem mass spectrometry (LC–MS/MS). The in vitro effect of the metabolites against F. hepatica was investigated using a phenotype-based assay and scanning electron microscopy (SEM). Following artesunate applications (40 and 60 mg/kg), comparable Cmax (maximal plasma concentration) and AUCs (area under the plasma concentration–time curve) were observed for artesunate (Cmax: 8.4 × 103 and 9.4 × 103 ng/ml; AUC: 6.9 × 105 and 9.7 × 105 ng min/ml), DHA (Cmax: both 2.4 × 103 ng/ml; AUC: 3.7 × 105 and 5.0 × 105 ng min/ml), and DHA-glucuronide (Cmax: 1.7 × 104 and 1.6 × 104 ng/ml; AUC: 2.6 × 106 and 3.3 × 106 ng min/ml). Mean elimination half-lifes (t1/2) of artesunate, DHA and DHA-glucuronide ranged between 58 and 63 min, 94 and 113 min, and 89 and 98 min, respectively. The i.m. oil-based drug formulation liberated artemether slowly and constant levels of artemether and its metabolites were observed during the entire sampling period (24 h). The AUCs of all analytes were significantly higher for the i.m. 160 mg/kg dose compared to i.m. 40 and oral 80 mg/kg doses (P = 0.018). Mean Cmax of artemether (2126 and 426 ng/ml) and DHA-glucuronide (3477 and 1587 ng/ml) were higher following oral compared to i.m. (160 mg/kg) treatments (P > 0.068), whereas Cmax of DHA was significantly higher following i.m. applications (P = 0.0062). DHA rapidly reduced the viability of F. hepatica in vitro, whereas DHA-glucuronide showed no activity. SEM observations revealed only minor and focal tegumental alterations in few of the DHA treated worms. The calculated PK parameters reflect the anthelmintic activity of artesunate and artemether following different routes of application and will aid in the design of future studies with these drugs." @default.
• W1963731407 created "2016-06-24" @default.
• W1963731407 creator A5013191325 @default.
• W1963731407 creator A5021437189 @default.
• W1963731407 creator A5024133720 @default.
• W1963731407 creator A5033452459 @default.
• W1963731407 creator A5087393240 @default.
• W1963731407 date "2012-05-01" @default.
• W1963731407 modified "2023-09-23" @default.
• W1963731407 title "Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with Fasciola hepatica" @default.
• W1963731407 cites W1674976578 @default.
• W1963731407 cites W1987646859 @default.
• W1963731407 cites W1989426152 @default.
• W1963731407 cites W2003242915 @default.
• W1963731407 cites W2004505354 @default.
• W1963731407 cites W2013733279 @default.
• W1963731407 cites W2014555589 @default.
• W1963731407 cites W2015578047 @default.
• W1963731407 cites W2028301397 @default.
• W1963731407 cites W2045075086 @default.
• W1963731407 cites W2046445824 @default.
• W1963731407 cites W2047466881 @default.
• W1963731407 cites W2048883882 @default.
• W1963731407 cites W2053627879 @default.
• W1963731407 cites W2056719597 @default.
• W1963731407 cites W2062432224 @default.
• W1963731407 cites W2063404482 @default.
• W1963731407 cites W2073015741 @default.
• W1963731407 cites W2074578354 @default.
• W1963731407 cites W2076029682 @default.
• W1963731407 cites W2082999536 @default.
• W1963731407 cites W2091563096 @default.
• W1963731407 cites W2096173641 @default.
• W1963731407 cites W2096407013 @default.
• W1963731407 cites W2097451863 @default.
• W1963731407 cites W2100518513 @default.
• W1963731407 cites W2109388003 @default.
• W1963731407 cites W2119292094 @default.
• W1963731407 cites W2124910603 @default.
• W1963731407 cites W2140388607 @default.
• W1963731407 cites W2145891295 @default.
• W1963731407 cites W2169423026 @default.
• W1963731407 cites W2419602468 @default.
• W1963731407 doi "https://doi.org/10.1016/j.vetpar.2011.11.076" @default.
• W1963731407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22206644" @default.
• W1963731407 hasPublicationYear "2012" @default.
• W1963731407 type Work @default.
• W1963731407 sameAs 1963731407 @default.
• W1963731407 citedByCount "12" @default.
• W1963731407 countsByYear W19637314072012 @default.
• W1963731407 countsByYear W19637314072015 @default.
• W1963731407 countsByYear W19637314072016 @default.
• W1963731407 countsByYear W19637314072018 @default.
• W1963731407 countsByYear W19637314072020 @default.
• W1963731407 countsByYear W19637314072021 @default.
• W1963731407 crossrefType "journal-article" @default.
• W1963731407 hasAuthorship W1963731407A5013191325 @default.
• W1963731407 hasAuthorship W1963731407A5021437189 @default.
• W1963731407 hasAuthorship W1963731407A5024133720 @default.
• W1963731407 hasAuthorship W1963731407A5033452459 @default.
• W1963731407 hasAuthorship W1963731407A5087393240 @default.
• W1963731407 hasConcept C112705442 @default.
• W1963731407 hasConcept C185592680 @default.
• W1963731407 hasConcept C203014093 @default.
• W1963731407 hasConcept C22979827 @default.
• W1963731407 hasConcept C2776120307 @default.
• W1963731407 hasConcept C2776908094 @default.
• W1963731407 hasConcept C2777477808 @default.
• W1963731407 hasConcept C2778048844 @default.
• W1963731407 hasConcept C2778059366 @default.
• W1963731407 hasConcept C2778118209 @default.
• W1963731407 hasConcept C2778371730 @default.
• W1963731407 hasConcept C2779186261 @default.
• W1963731407 hasConcept C2781160685 @default.
• W1963731407 hasConcept C2911069016 @default.
• W1963731407 hasConcept C42972112 @default.
• W1963731407 hasConcept C43617362 @default.
• W1963731407 hasConcept C55493867 @default.
• W1963731407 hasConcept C71924100 @default.
• W1963731407 hasConcept C86803240 @default.
• W1963731407 hasConcept C98274493 @default.
• W1963731407 hasConceptScore W1963731407C112705442 @default.
• W1963731407 hasConceptScore W1963731407C185592680 @default.
• W1963731407 hasConceptScore W1963731407C203014093 @default.
• W1963731407 hasConceptScore W1963731407C22979827 @default.
• W1963731407 hasConceptScore W1963731407C2776120307 @default.
• W1963731407 hasConceptScore W1963731407C2776908094 @default.
• W1963731407 hasConceptScore W1963731407C2777477808 @default.
• W1963731407 hasConceptScore W1963731407C2778048844 @default.
• W1963731407 hasConceptScore W1963731407C2778059366 @default.
• W1963731407 hasConceptScore W1963731407C2778118209 @default.
• W1963731407 hasConceptScore W1963731407C2778371730 @default.
• W1963731407 hasConceptScore W1963731407C2779186261 @default.
• W1963731407 hasConceptScore W1963731407C2781160685 @default.
• W1963731407 hasConceptScore W1963731407C2911069016 @default.
• W1963731407 hasConceptScore W1963731407C42972112 @default.
• W1963731407 hasConceptScore W1963731407C43617362 @default.
• W1963731407 hasConceptScore W1963731407C55493867 @default.

• next