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• W1963735785 abstract "The neutral- and basic-amino-acid-transport glycoprotein NBAT (rBAT, D2) expressed in renal and jejunal brush-border membranes interacts with the b0,+AT permease to produce a heteromeric transporter effecting amino acid and cystine absorption. NBAT mutations result in type I cystinuria. The b0,+AT permease is presumed to be the catalytic subunit, but we have been investigating the possibility that cysteine residues within the C-terminus of NBAT are also important for expression of transport function. NBAT mutants were produced with combinations of Cys664/671/683 → Ala substitutions. Mutants with Cys664 → Ala show decreased arginine and cystine transport and specifically lose sensitivity to inhibition of transport by the thiol-group reagent N-ethylmaleimide (NEM). We suggest that the C-terminus of NBAT may have a direct role in the mechanism of System b0,+ transport (the major transport activity defective in type I cystinuria) and that Cys664 of NBAT is the major target for NEM-induced inactivation of the transport mechanism." @default.
• W1963735785 created "2016-06-24" @default.
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• W1963735785 date "2000-10-24" @default.
• W1963735785 modified "2023-09-23" @default.
• W1963735785 title "Cysteine residues in the C-terminus of the neutral- and basic-amino-acid transporter heavy-chain subunit contribute to functional properties of the system b0,+-type amino acid transporter" @default.
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• W1963735785 doi "https://doi.org/10.1042/bj3510677" @default.
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