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• W1963737701 abstract "Tyrosine hydroxylase (TH) activity, the rate-limiting step in the synthesis of catecholamines, was quantified in the preoptic area-hypothalamus of adult male Japanese quail by a new assay measuring the tritiated water production from 3,5-[ 3 H]-L-tyrosine. Maximal levels of activity were observed at a 20–25 μM concentration of substrate, with more than 50% inhibition of the activity being recorded at a 100 μM concentration. TH activity was linear as a function of the incubation time during the first 20 min and maximal at a pH of 6.0. TH was heterogeneously distributed in the quail brain with highest levels of activity being found (in decreasing order) in the mesencephalon, diencephalon, and telencephalon. Given the large size of the telencephalon, this is the brain area that contains, as a whole, the highest level of enzyme activity. TH inhibitors that have been well-characterized in mammals, such as 3-iodo- l -tyrosine and l -α-methyl-p-tyrosine (AMPT) completely inhibited the enzyme activity at a 100 μM concentration. In mammals, the accumulation of catecholamines exerts a negative feedback control on TH activity. Similar controls were observed in the quail brain. Two inhibitors of the DOPA decarboxylase that should lead to accumulation of DOPA depressed TH activity by 60% or more, and the inhibitor of the dopamine β-hydroxylase, fusaric acid that should cause an accumulation of dopamine, suppressed 90% of the TH activity. The addition of exogenous DOPA, dopamine, or norepinephrine to the brain homogenates also strongly inhibited TH activity, independently confirming the feedback effects of the enzyme products on the enzyme activity. These data demonstrate that TH activity in the quail brain is heterogeneously distributed and acutely regulated, as it is in mammals, by the accumulation of its products and of the derived catecholamines." @default.
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• W1963737701 date "1999-01-01" @default.
• W1963737701 modified "2023-09-24" @default.
• W1963737701 title "Regional distribution and control of tyrosine hydroxylase activity in the quail brain" @default.
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• W1963737701 doi "https://doi.org/10.1016/s0361-9230(98)00141-5" @default.
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