FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963738775> ?p ?o ?g. }

• W1963738775 endingPage "3782" @default.
• W1963738775 startingPage "3771" @default.
• W1963738775 abstract "Abstract Purpose: p14ARF, p15INK4b, and p16INK4a are tumor suppressor genes that are located closely at 9p21 and are often coinactivated by genetic or epigenetic alterations. Malignant peripheral nerve sheath tumor (MPNST) is a rare sarcoma with poor prognosis. However, the prognostic implications of inactivation of p14ARF, p15INK4b, and p16INK4a in MPNSTs have not been adequately investigated. Here we carried out a genetic, epigenetic, and expression analysis of p14ARF, p15INK4b, and p16INK4a, and clarified the prognostic significance of their inactivation in MPNSTs. Experimental Design: p14ARF, p15INK4b, and p16INK4a protein expressions were assessed by immunohistochemistry in 129 formalin-fixed samples of MPNST including 85 primary tumors. Thirty-nine samples, for which frozen material was available, were also investigated by Western blotting and quantitative reverse transcription PCR (RT-PCR) to detect p14ARF, p15INK4b, and p16INK4a protein and mRNA expression, and by multiplex real-time PCR, PCR single strand conformation polymorphism and methylation-specific PCR to detect p14ARF, p15INK4b, and p16INK4a gene alterations. Results: Immunohistochemically decreased expressions of p14ARF, p15INK4b, and p16INK4a were observed in 48%, 54%, and 49% of primary MPNSTs, respectively, and were significantly correlated with their concordant mRNA levels. As for gene alterations, homozygous deletion of CDKN2A was detected in one third of the cases. Inactivation of p14ARF and p16INK4a was associated with poor prognosis by both univariate and multivariate analyses. Furthermore, cases with inactivation of all p14ARF, p15INK4b, and p16INK4a genes showed the worst prognosis in a combined prognostic assessment. Conclusion: A comprehensive analysis of p14ARF, p15INK4b, and p16INK4a inactivation status provides useful prognostic information in MPNSTs. Clin Cancer Res; 17(11); 3771–82. ©2011 AACR." @default.
• W1963738775 created "2016-06-24" @default.
• W1963738775 creator A5011966088 @default.
• W1963738775 creator A5012193751 @default.
• W1963738775 creator A5025082835 @default.
• W1963738775 creator A5032753253 @default.
• W1963738775 creator A5041401659 @default.
• W1963738775 creator A5041701717 @default.
• W1963738775 creator A5042141137 @default.
• W1963738775 creator A5048041895 @default.
• W1963738775 creator A5048210816 @default.
• W1963738775 creator A5053242194 @default.
• W1963738775 creator A5083645230 @default.
• W1963738775 date "2011-06-01" @default.
• W1963738775 modified "2023-10-17" @default.
• W1963738775 title "Prognostic Significance of <i>p14ARF</i>, <i>p15INK4b</i>, and <i>p16INK4a</i> Inactivation in Malignant Peripheral Nerve Sheath Tumors" @default.
• W1963738775 cites W1966503073 @default.
• W1963738775 cites W1971656848 @default.
• W1963738775 cites W1973262551 @default.
• W1963738775 cites W1978923120 @default.
• W1963738775 cites W1987368810 @default.
• W1963738775 cites W1992013240 @default.
• W1963738775 cites W1994136498 @default.
• W1963738775 cites W1994926857 @default.
• W1963738775 cites W1996041514 @default.
• W1963738775 cites W2000690172 @default.
• W1963738775 cites W2003650911 @default.
• W1963738775 cites W2008597053 @default.
• W1963738775 cites W2008900878 @default.
• W1963738775 cites W2010998374 @default.
• W1963738775 cites W2013204218 @default.
• W1963738775 cites W2022670831 @default.
• W1963738775 cites W2023627857 @default.
• W1963738775 cites W202730752 @default.
• W1963738775 cites W2028319593 @default.
• W1963738775 cites W2032013231 @default.
• W1963738775 cites W2032220244 @default.
• W1963738775 cites W2045722716 @default.
• W1963738775 cites W2053442386 @default.
• W1963738775 cites W2054616973 @default.
• W1963738775 cites W2055290230 @default.
• W1963738775 cites W2055729102 @default.
• W1963738775 cites W2063057728 @default.
• W1963738775 cites W2069886811 @default.
• W1963738775 cites W2071734901 @default.
• W1963738775 cites W2087954736 @default.
• W1963738775 cites W2091066174 @default.
• W1963738775 cites W2099205967 @default.
• W1963738775 cites W2106243126 @default.
• W1963738775 cites W2109848825 @default.
• W1963738775 cites W2111524617 @default.
• W1963738775 cites W2121733985 @default.
• W1963738775 cites W2128014524 @default.
• W1963738775 cites W2130281666 @default.
• W1963738775 cites W2156380736 @default.
• W1963738775 cites W2163258576 @default.
• W1963738775 cites W2171664001 @default.
• W1963738775 cites W2339412923 @default.
• W1963738775 doi "https://doi.org/10.1158/1078-0432.ccr-10-2393" @default.
• W1963738775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21262917" @default.
• W1963738775 hasPublicationYear "2011" @default.
• W1963738775 type Work @default.
• W1963738775 sameAs 1963738775 @default.
• W1963738775 citedByCount "48" @default.
• W1963738775 countsByYear W19637387752012 @default.
• W1963738775 countsByYear W19637387752013 @default.
• W1963738775 countsByYear W19637387752014 @default.
• W1963738775 countsByYear W19637387752015 @default.
• W1963738775 countsByYear W19637387752016 @default.
• W1963738775 countsByYear W19637387752017 @default.
• W1963738775 countsByYear W19637387752018 @default.
• W1963738775 countsByYear W19637387752019 @default.
• W1963738775 countsByYear W19637387752020 @default.
• W1963738775 countsByYear W19637387752021 @default.
• W1963738775 countsByYear W19637387752022 @default.
• W1963738775 crossrefType "journal-article" @default.
• W1963738775 hasAuthorship W1963738775A5011966088 @default.
• W1963738775 hasAuthorship W1963738775A5012193751 @default.
• W1963738775 hasAuthorship W1963738775A5025082835 @default.
• W1963738775 hasAuthorship W1963738775A5032753253 @default.
• W1963738775 hasAuthorship W1963738775A5041401659 @default.
• W1963738775 hasAuthorship W1963738775A5041701717 @default.
• W1963738775 hasAuthorship W1963738775A5042141137 @default.
• W1963738775 hasAuthorship W1963738775A5048041895 @default.
• W1963738775 hasAuthorship W1963738775A5048210816 @default.
• W1963738775 hasAuthorship W1963738775A5053242194 @default.
• W1963738775 hasAuthorship W1963738775A5083645230 @default.
• W1963738775 hasConcept C104317684 @default.
• W1963738775 hasConcept C142724271 @default.
• W1963738775 hasConcept C204232928 @default.
• W1963738775 hasConcept C2776750431 @default.
• W1963738775 hasConcept C2778264664 @default.
• W1963738775 hasConcept C41091548 @default.
• W1963738775 hasConcept C502942594 @default.
• W1963738775 hasConcept C54355233 @default.
• W1963738775 hasConcept C555283112 @default.
• W1963738775 hasConcept C71924100 @default.
• W1963738775 hasConcept C86803240 @default.

• next