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• W1963761882 endingPage "1073" @default.
• W1963761882 startingPage "1063" @default.
• W1963761882 abstract "The cystic fibrosis transmembrane conductance regulator (CFTR) functions to regulate both Cl- and Na+ conductive pathways; however, the cellular mechanisms whereby CFTR acts as a conductance regulator are unknown. CFTR and outwardly rectifying Cl- channels (ORCCs) are distinct channels but are linked functionally via an unknown regulatory mechanism. We present results from whole-cell and single-channel patch-clamp recordings, short-circuit current recordings, and [gamma-32P]ATP release assays of normal, CF, and wild-type or mutant CFTR-transfected CF airway cultured epithelial cells wherein CFTR regulates ORCCs by triggering the transport of the potent agonist, ATP, out of the cell. Once released, ATP stimulates ORCCs through a P2U purinergic receptor-dependent signaling mechanism. Our results suggest that CFTR functions to regulate other Cl- secretory pathways in addition to itself conducting Cl-." @default.
• W1963761882 created "2016-06-24" @default.
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• W1963761882 date "1995-06-01" @default.
• W1963761882 modified "2023-10-17" @default.
• W1963761882 title "CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP" @default.
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• W1963761882 doi "https://doi.org/10.1016/s0092-8674(05)80011-x" @default.
• W1963761882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7541313" @default.
• W1963761882 hasPublicationYear "1995" @default.
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