Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963762892> ?p ?o ?g. }
- W1963762892 endingPage "230" @default.
- W1963762892 startingPage "220" @default.
- W1963762892 abstract "α-Methylacyl-CoA racemase (AMACR; P504S) catalyzes a key chiral inversion step in the metabolism of branched-chain fatty acids, ibuprofen and related drugs. Protein levels are increased in all prostate and some other cancer cells and it is used as a marker (P504S). The enzyme requires no cofactors and catalyzes its reaction by a stepwise 1,1-proton transfer via an enolate intermediate. The biological role of AMACR in cancer is complex, linking lipid metabolism with nuclear receptor (e.g. FXR and PPAR) activity and expression of enzymes such as cyclooxygenase-2 (COX-2). The roles of the various splice variants and the effects of single-nucleotide polymorphisms (SNPs) in cancers are discussed. A number of rationally designed AMACR inhibitors have been reported in the literature as potential cancer treatments. The opportunities and challenges for development of acyl-CoA esters as inhibitors are discussed from a medicinal chemical viewpoint. Other challenges for drug development include the problems in assaying enzymatic activity and the prediction of structure–activity relationships (SAR). Inhibitors of AMACR have potential to provide a novel treatment for castrate-resistant prostate cancers but this potential can only be realized once the biology is well understood. Recent work on the role of AMACR in parasitic diseases is also reviewed." @default.
- W1963762892 created "2016-06-24" @default.
- W1963762892 creator A5016634968 @default.
- W1963762892 creator A5024872462 @default.
- W1963762892 creator A5036024913 @default.
- W1963762892 creator A5044872143 @default.
- W1963762892 creator A5050901446 @default.
- W1963762892 creator A5087632688 @default.
- W1963762892 date "2013-04-01" @default.
- W1963762892 modified "2023-10-17" @default.
- W1963762892 title "α-Methylacyl-CoA racemase (AMACR): Metabolic enzyme, drug metabolizer and cancer marker P504S" @default.
- W1963762892 cites W133579928 @default.
- W1963762892 cites W1496079625 @default.
- W1963762892 cites W1512119355 @default.
- W1963762892 cites W1516122519 @default.
- W1963762892 cites W1550877969 @default.
- W1963762892 cites W1603636427 @default.
- W1963762892 cites W1872235201 @default.
- W1963762892 cites W1930548389 @default.
- W1963762892 cites W1931269632 @default.
- W1963762892 cites W1964319629 @default.
- W1963762892 cites W1966056172 @default.
- W1963762892 cites W1966844676 @default.
- W1963762892 cites W1968476790 @default.
- W1963762892 cites W1971930456 @default.
- W1963762892 cites W1972203402 @default.
- W1963762892 cites W1973940014 @default.
- W1963762892 cites W1974647796 @default.
- W1963762892 cites W1974921983 @default.
- W1963762892 cites W1975921234 @default.
- W1963762892 cites W1976460019 @default.
- W1963762892 cites W1977723976 @default.
- W1963762892 cites W1982532297 @default.
- W1963762892 cites W1985786011 @default.
- W1963762892 cites W1986865985 @default.
- W1963762892 cites W1987684836 @default.
- W1963762892 cites W1988117658 @default.
- W1963762892 cites W1989929509 @default.
- W1963762892 cites W1990104922 @default.
- W1963762892 cites W1990221452 @default.
- W1963762892 cites W1991398328 @default.
- W1963762892 cites W1992869265 @default.
- W1963762892 cites W1992983497 @default.
- W1963762892 cites W1993501421 @default.
- W1963762892 cites W1994753207 @default.
- W1963762892 cites W1995188759 @default.
- W1963762892 cites W1995527507 @default.
- W1963762892 cites W1995620315 @default.
- W1963762892 cites W1998884175 @default.
- W1963762892 cites W2002076420 @default.
- W1963762892 cites W2003231030 @default.
- W1963762892 cites W2003766057 @default.
- W1963762892 cites W2004369467 @default.
- W1963762892 cites W2004617223 @default.
- W1963762892 cites W2006381997 @default.
- W1963762892 cites W2012251449 @default.
- W1963762892 cites W2012810767 @default.
- W1963762892 cites W2014737230 @default.
- W1963762892 cites W2015682308 @default.
- W1963762892 cites W2016729644 @default.
- W1963762892 cites W2018611428 @default.
- W1963762892 cites W2020042552 @default.
- W1963762892 cites W2020215351 @default.
- W1963762892 cites W2021039059 @default.
- W1963762892 cites W2021212793 @default.
- W1963762892 cites W2022040614 @default.
- W1963762892 cites W2022240786 @default.
- W1963762892 cites W2022904488 @default.
- W1963762892 cites W2023505217 @default.
- W1963762892 cites W2023538708 @default.
- W1963762892 cites W2023672806 @default.
- W1963762892 cites W2024087814 @default.
- W1963762892 cites W2024400005 @default.
- W1963762892 cites W2026281923 @default.
- W1963762892 cites W2026625413 @default.
- W1963762892 cites W2027614771 @default.
- W1963762892 cites W2029376999 @default.
- W1963762892 cites W2030764285 @default.
- W1963762892 cites W2035161956 @default.
- W1963762892 cites W2035644151 @default.
- W1963762892 cites W2037500661 @default.
- W1963762892 cites W2038927545 @default.
- W1963762892 cites W2041712203 @default.
- W1963762892 cites W2042118473 @default.
- W1963762892 cites W2043038230 @default.
- W1963762892 cites W2043355377 @default.
- W1963762892 cites W2045223571 @default.
- W1963762892 cites W2045901769 @default.
- W1963762892 cites W2047236275 @default.
- W1963762892 cites W2050590566 @default.
- W1963762892 cites W2050826311 @default.
- W1963762892 cites W2052268395 @default.
- W1963762892 cites W2053088786 @default.
- W1963762892 cites W2053433145 @default.
- W1963762892 cites W2057095795 @default.
- W1963762892 cites W2059196221 @default.
- W1963762892 cites W2060171340 @default.
- W1963762892 cites W2060768796 @default.