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- W1963769095 abstract "Since aberrant crypt foci (ACF) were first described in 1987, they have been the subjects of hundreds of papers; however, the debate continues about their role in colorectal tumorigenesis. This review focuses on the many phenotypic, genetic and epigenetic alterations in ACF that support the hypothesis that ACF are putative precursors of colorectal cancer in both humans and experimental animals. Human ACF, both with and without dysplasia, are monoclonal and display evidence of chromosomal instability. Both of these characteristics are shared by colorectal cancers. While most ACF do not have APC mutations, a large proportion has KRAS mutations and methylated SFRP1 and SFRP2 genes. This epigenetic inactivation gives rise to constitutive Wnt signaling in these putative precursors of colorectal cancer." @default.
- W1963769095 created "2016-06-24" @default.
- W1963769095 creator A5016328047 @default.
- W1963769095 creator A5030552057 @default.
- W1963769095 date "2005-11-01" @default.
- W1963769095 modified "2023-10-17" @default.
- W1963769095 title "Mutant KRAS in aberrant crypt foci (ACF): Initiation of colorectal cancer?" @default.
- W1963769095 cites W1500074869 @default.
- W1963769095 cites W1907210134 @default.
- W1963769095 cites W1966997112 @default.
- W1963769095 cites W1967221918 @default.
- W1963769095 cites W1967831270 @default.
- W1963769095 cites W1968763775 @default.
- W1963769095 cites W1969543917 @default.
- W1963769095 cites W1970445829 @default.
- W1963769095 cites W1971109474 @default.
- W1963769095 cites W1971357787 @default.
- W1963769095 cites W1972274958 @default.
- W1963769095 cites W1973723373 @default.
- W1963769095 cites W1976056213 @default.
- W1963769095 cites W1977087431 @default.
- W1963769095 cites W1978424116 @default.
- W1963769095 cites W1980847511 @default.
- W1963769095 cites W1990489545 @default.
- W1963769095 cites W1990691513 @default.
- W1963769095 cites W1992682395 @default.
- W1963769095 cites W1995714303 @default.
- W1963769095 cites W1995819860 @default.
- W1963769095 cites W1996588062 @default.
- W1963769095 cites W1997583523 @default.
- W1963769095 cites W1999643642 @default.
- W1963769095 cites W2001258296 @default.
- W1963769095 cites W2004098247 @default.
- W1963769095 cites W2007278554 @default.
- W1963769095 cites W2010875436 @default.
- W1963769095 cites W2012814689 @default.
- W1963769095 cites W2013311105 @default.
- W1963769095 cites W2013320174 @default.
- W1963769095 cites W2013585029 @default.
- W1963769095 cites W2016893223 @default.
- W1963769095 cites W2018348035 @default.
- W1963769095 cites W2018659215 @default.
- W1963769095 cites W2018864636 @default.
- W1963769095 cites W2019781712 @default.
- W1963769095 cites W2021706178 @default.
- W1963769095 cites W2022471636 @default.
- W1963769095 cites W2025338847 @default.
- W1963769095 cites W2031372290 @default.
- W1963769095 cites W2033102805 @default.
- W1963769095 cites W2038418056 @default.
- W1963769095 cites W2038878316 @default.
- W1963769095 cites W2039458334 @default.
- W1963769095 cites W2039786451 @default.
- W1963769095 cites W2042277011 @default.
- W1963769095 cites W2043509153 @default.
- W1963769095 cites W2043869692 @default.
- W1963769095 cites W2044643325 @default.
- W1963769095 cites W2045341592 @default.
- W1963769095 cites W2047330711 @default.
- W1963769095 cites W2058047917 @default.
- W1963769095 cites W2059198233 @default.
- W1963769095 cites W2059969113 @default.
- W1963769095 cites W2067089521 @default.
- W1963769095 cites W2070754803 @default.
- W1963769095 cites W2072899483 @default.
- W1963769095 cites W2073928750 @default.
- W1963769095 cites W2074907228 @default.
- W1963769095 cites W2076724549 @default.
- W1963769095 cites W2080308138 @default.
- W1963769095 cites W2081472641 @default.
- W1963769095 cites W2088033808 @default.
- W1963769095 cites W2088987931 @default.
- W1963769095 cites W2091326952 @default.
- W1963769095 cites W2091723114 @default.
- W1963769095 cites W2093531978 @default.
- W1963769095 cites W2094850601 @default.
- W1963769095 cites W2094994900 @default.
- W1963769095 cites W2095127214 @default.
- W1963769095 cites W2095637318 @default.
- W1963769095 cites W2099468308 @default.
- W1963769095 cites W2102558232 @default.
- W1963769095 cites W2106212265 @default.
- W1963769095 cites W2112006923 @default.
- W1963769095 cites W2113678049 @default.
- W1963769095 cites W2113885141 @default.
- W1963769095 cites W2118724609 @default.
- W1963769095 cites W2120045074 @default.
- W1963769095 cites W2121827163 @default.
- W1963769095 cites W2125459722 @default.
- W1963769095 cites W2127218675 @default.
- W1963769095 cites W2138756913 @default.
- W1963769095 cites W2140901152 @default.
- W1963769095 cites W2141815643 @default.
- W1963769095 cites W2143399692 @default.
- W1963769095 cites W2148310694 @default.
- W1963769095 cites W2148570472 @default.
- W1963769095 cites W2149219789 @default.
- W1963769095 cites W2152465918 @default.