FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963783971> ?p ?o ?g. }

• W1963783971 endingPage "183" @default.
• W1963783971 startingPage "173" @default.
• W1963783971 abstract "Studies were performed to determine the regulation of DMT1 (divalent metal transporter 1) during RA (retinoic acid)-induced differentiation of P19 embryonic carcinoma cells. Protein and mRNA expression for the +/−IRE (iron response element) forms of DMT1, but not the 1A isoform, were down-regulated within the first few hours upon removal of RA, at which time the cells began to differentiate. The turnover of the +/−IRE isoforms of DMT1 protein during this period was found to be dependent on both the proteasomal and lysosomal pathways. Changes in mRNA levels were shown to be regulated by nitric oxide produced by the induction of neuronal nitric oxide synthase after removal of RA. Nitric oxide functions by inhibiting NF-κB (nuclear factor κB) nuclear translocation and the subsequent binding to the putative NF-κB response element (at −19 to −23) within the 1B promoter. Gel-shift analysis and chromatin immunoprecipitation assay indicated that nuclear NF-κB is capable of binding to this response element and that binding decreases during early stages of differentiation. Luciferase reporter gene assay demonstrated that a mutation in this binding domain leads to decreased activity. These results demonstrate that during neuronal differentiation of P19 cells, there is a decrease in specific isoforms of DMT1 via both post-translational and transcriptional mechanisms." @default.
• W1963783971 created "2016-06-24" @default.
• W1963783971 creator A5041894302 @default.
• W1963783971 creator A5056708119 @default.
• W1963783971 date "2006-01-27" @default.
• W1963783971 modified "2023-10-17" @default.
• W1963783971 title "Post-translational and transcriptional regulation of DMT1 during P19 embryonic carcinoma cell differentiation by retinoic acid" @default.
• W1963783971 cites W12952247 @default.
• W1963783971 cites W1552448470 @default.
• W1963783971 cites W1568628619 @default.
• W1963783971 cites W1718768577 @default.
• W1963783971 cites W1966792207 @default.
• W1963783971 cites W1968581250 @default.
• W1963783971 cites W1970826202 @default.
• W1963783971 cites W1972235279 @default.
• W1963783971 cites W1972304812 @default.
• W1963783971 cites W1974541233 @default.
• W1963783971 cites W1974614108 @default.
• W1963783971 cites W1988045984 @default.
• W1963783971 cites W1990259051 @default.
• W1963783971 cites W1996350615 @default.
• W1963783971 cites W1998851985 @default.
• W1963783971 cites W1999799747 @default.
• W1963783971 cites W2001919177 @default.
• W1963783971 cites W2025234158 @default.
• W1963783971 cites W2027736032 @default.
• W1963783971 cites W2027815400 @default.
• W1963783971 cites W2029635682 @default.
• W1963783971 cites W2031949055 @default.
• W1963783971 cites W2036564332 @default.
• W1963783971 cites W2037370154 @default.
• W1963783971 cites W2042896578 @default.
• W1963783971 cites W2043286349 @default.
• W1963783971 cites W2049399172 @default.
• W1963783971 cites W2064879068 @default.
• W1963783971 cites W2072992323 @default.
• W1963783971 cites W2079509305 @default.
• W1963783971 cites W2083962064 @default.
• W1963783971 cites W2099466487 @default.
• W1963783971 cites W2117592417 @default.
• W1963783971 cites W2121348633 @default.
• W1963783971 cites W2127695183 @default.
• W1963783971 cites W2127751018 @default.
• W1963783971 cites W2129599465 @default.
• W1963783971 cites W2141430946 @default.
• W1963783971 cites W2146155522 @default.
• W1963783971 cites W2156116739 @default.
• W1963783971 cites W93114066 @default.
• W1963783971 doi "https://doi.org/10.1042/bj20051296" @default.
• W1963783971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1386015" @default.
• W1963783971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16232120" @default.
• W1963783971 hasPublicationYear "2006" @default.
• W1963783971 type Work @default.
• W1963783971 sameAs 1963783971 @default.
• W1963783971 citedByCount "37" @default.
• W1963783971 countsByYear W19637839712012 @default.
• W1963783971 countsByYear W19637839712013 @default.
• W1963783971 countsByYear W19637839712014 @default.
• W1963783971 countsByYear W19637839712015 @default.
• W1963783971 countsByYear W19637839712017 @default.
• W1963783971 countsByYear W19637839712018 @default.
• W1963783971 countsByYear W19637839712019 @default.
• W1963783971 countsByYear W19637839712020 @default.
• W1963783971 countsByYear W19637839712021 @default.
• W1963783971 countsByYear W19637839712022 @default.
• W1963783971 crossrefType "journal-article" @default.
• W1963783971 hasAuthorship W1963783971A5041894302 @default.
• W1963783971 hasAuthorship W1963783971A5056708119 @default.
• W1963783971 hasBestOaLocation W19637839712 @default.
• W1963783971 hasConcept C101762097 @default.
• W1963783971 hasConcept C104317684 @default.
• W1963783971 hasConcept C134320426 @default.
• W1963783971 hasConcept C148738053 @default.
• W1963783971 hasConcept C149011108 @default.
• W1963783971 hasConcept C150194340 @default.
• W1963783971 hasConcept C153911025 @default.
• W1963783971 hasConcept C183978625 @default.
• W1963783971 hasConcept C185592680 @default.
• W1963783971 hasConcept C20875687 @default.
• W1963783971 hasConcept C26805974 @default.
• W1963783971 hasConcept C2776531687 @default.
• W1963783971 hasConcept C2781121885 @default.
• W1963783971 hasConcept C29512474 @default.
• W1963783971 hasConcept C53345823 @default.
• W1963783971 hasConcept C55493867 @default.
• W1963783971 hasConcept C86339819 @default.
• W1963783971 hasConcept C86803240 @default.
• W1963783971 hasConcept C95444343 @default.
• W1963783971 hasConceptScore W1963783971C101762097 @default.
• W1963783971 hasConceptScore W1963783971C104317684 @default.
• W1963783971 hasConceptScore W1963783971C134320426 @default.
• W1963783971 hasConceptScore W1963783971C148738053 @default.
• W1963783971 hasConceptScore W1963783971C149011108 @default.
• W1963783971 hasConceptScore W1963783971C150194340 @default.
• W1963783971 hasConceptScore W1963783971C153911025 @default.
• W1963783971 hasConceptScore W1963783971C183978625 @default.
• W1963783971 hasConceptScore W1963783971C185592680 @default.
• W1963783971 hasConceptScore W1963783971C20875687 @default.

• next