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- W1963795745 abstract "RATIONALE: Previously, mitogen-induced interferon (IFN) responses at birth were shown to be inversely correlated with illness frequency. Here we more comprehensively evaluate whether variations in immunologic responses at birth to multiple innate and mitogen stimuli are associated with the risk of acquiring respiratory illnesses during early childhood. METHODS: Cord blood mononuclear cells were obtained at birth from 285 children enrolled in the Childhood Origins of ASThma (COAST) study. After stimulating them with multiple mitogen and innate stimuli (including PHA, LPS, PMA, RV, RSV, and SAC), IFN-γ, IL-6, IL-10, IL-12, IFN-α, and TNF-α were measured. Cytokine levels were correlated to the frequency of moderate to severe respiratory illnesses (MSIs) during the first 3 years of life. A Spearman correlation was utilized for cytokine/stimuli pairs for which ≥75% of patient samples had detectable results; a Wilcoxon rank-sum test was used below this threshold. RESULTS: Of all stimuli/cytokine pairs analyzed, the most consistent finding was with IFNs. IFN-γ levels in cord blood were lower in children who developed more respiratory illnesses for the following stimulants: PMA (r = -0.16, p = 0.008), PHA (r = -0.12, p = 0.05), RSV (detectable vs. undetectable: 5.03 vs. 5.93 MSIs, p = 0.07), and LPS (detectable vs. undetectable: 3.83 vs. 6.2 MSIs, p = 0.1). Similarly, LPS-induced IFN-α levels were lower in children who developed more respiratory illnesses (r = -0.23, p = 0.02). CONCLUSIONS: Greater interferon responses to multiple innate and mitogen stimuli at birth appear to be protective against the development of frequent respiratory illnesses during early childhood." @default.
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- W1963795745 date "2009-02-01" @default.
- W1963795745 modified "2023-10-05" @default.
- W1963795745 title "Innate Immune Response Profiles and Their Relationship to the Frequency of Respiratory Illnesses in the First Three Years of Life" @default.
- W1963795745 doi "https://doi.org/10.1016/j.jaci.2008.12.231" @default.
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