FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963807870> ?p ?o ?g. }

• W1963807870 endingPage "3723" @default.
• W1963807870 startingPage "3713" @default.
• W1963807870 abstract "Clear cell renal cell carcinomas (ccRCCs) are characterized by biallelic loss of the von Hippel-Lindau tumor suppressor and subsequent constitutive activation of the hypoxia-inducible factors, whose transcriptional programs dictate major phenotypic attributes of kidney tumors. We recently described a role for the macrophage migration inhibitory factor (MIF) in ccRCC as an autocrine-signaling molecule with elevated expression in tumor tissues and in the circulation of patients that has potent tumor cell survival effects. MIF is a pleiotropic cytokine implicated in a variety of diseases and cancers and is the target of both small molecule and antibody-based therapies currently in clinical trials. Recent work by others has described D-dopachrome tautomerase (DDT) as a functional homologue of MIF with a similar genomic structure and expression patterns. Thus, we sought to determine a role for DDT in renal cancer. We find that DDT expression mirrors MIF expression in ccRCC tumor sections with high correlation and that, mechanistically, DDT is a novel hypoxia-inducible gene and direct target of HIF1α and HIF2α. Functionally, DDT and MIF demonstrate a significant overlap in controlling cell survival, tumor formation, and tumor and endothelial cell migration. However, DDT inhibition consistently displayed more severe effects on most phenotypes. Accordingly, although dual inhibition of DDT and MIF demonstrated additive effects in vitro, DDT plays a dominant role in tumor growth in vivo. Together, our findings identify DDT as a functionally redundant but more potent cytokine to MIF in cancer and suggest that current attempts to inhibit MIF signaling may fail because of DDT compensation." @default.
• W1963807870 created "2016-06-24" @default.
• W1963807870 creator A5000930554 @default.
• W1963807870 creator A5008516074 @default.
• W1963807870 creator A5022992922 @default.
• W1963807870 creator A5029943599 @default.
• W1963807870 creator A5035518209 @default.
• W1963807870 creator A5044366958 @default.
• W1963807870 creator A5063835480 @default.
• W1963807870 date "2014-02-01" @default.
• W1963807870 modified "2023-10-05" @default.
• W1963807870 title "Dysregulated D-dopachrome Tautomerase, a Hypoxia-inducible Factor-dependent Gene, Cooperates with Macrophage Migration Inhibitory Factor in Renal Tumorigenesis" @default.
• W1963807870 cites W1584642143 @default.
• W1963807870 cites W1893818399 @default.
• W1963807870 cites W1961498819 @default.
• W1963807870 cites W1970596902 @default.
• W1963807870 cites W1977336393 @default.
• W1963807870 cites W1979244891 @default.
• W1963807870 cites W1991421091 @default.
• W1963807870 cites W1999670368 @default.
• W1963807870 cites W2006096547 @default.
• W1963807870 cites W2010950394 @default.
• W1963807870 cites W2014115244 @default.
• W1963807870 cites W2014245338 @default.
• W1963807870 cites W2015894544 @default.
• W1963807870 cites W2024064023 @default.
• W1963807870 cites W2029174607 @default.
• W1963807870 cites W2030494099 @default.
• W1963807870 cites W2047308155 @default.
• W1963807870 cites W2050691345 @default.
• W1963807870 cites W2066604995 @default.
• W1963807870 cites W2075894073 @default.
• W1963807870 cites W2087377825 @default.
• W1963807870 cites W2087441379 @default.
• W1963807870 cites W2092422722 @default.
• W1963807870 cites W2096042605 @default.
• W1963807870 cites W2102590613 @default.
• W1963807870 cites W2103506867 @default.
• W1963807870 cites W2114559468 @default.
• W1963807870 cites W2115681156 @default.
• W1963807870 cites W2118103791 @default.
• W1963807870 cites W2124496728 @default.
• W1963807870 cites W2127104790 @default.
• W1963807870 cites W2131581428 @default.
• W1963807870 cites W2144878837 @default.
• W1963807870 cites W2148270074 @default.
• W1963807870 cites W2161817637 @default.
• W1963807870 cites W2162068180 @default.
• W1963807870 cites W2342153330 @default.
• W1963807870 cites W294787083 @default.
• W1963807870 doi "https://doi.org/10.1074/jbc.m113.500694" @default.
• W1963807870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3916569" @default.
• W1963807870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24356968" @default.
• W1963807870 hasPublicationYear "2014" @default.
• W1963807870 type Work @default.
• W1963807870 sameAs 1963807870 @default.
• W1963807870 citedByCount "36" @default.
• W1963807870 countsByYear W19638078702014 @default.
• W1963807870 countsByYear W19638078702015 @default.
• W1963807870 countsByYear W19638078702016 @default.
• W1963807870 countsByYear W19638078702017 @default.
• W1963807870 countsByYear W19638078702018 @default.
• W1963807870 countsByYear W19638078702019 @default.
• W1963807870 countsByYear W19638078702020 @default.
• W1963807870 countsByYear W19638078702021 @default.
• W1963807870 countsByYear W19638078702022 @default.
• W1963807870 countsByYear W19638078702023 @default.
• W1963807870 crossrefType "journal-article" @default.
• W1963807870 hasAuthorship W1963807870A5000930554 @default.
• W1963807870 hasAuthorship W1963807870A5008516074 @default.
• W1963807870 hasAuthorship W1963807870A5022992922 @default.
• W1963807870 hasAuthorship W1963807870A5029943599 @default.
• W1963807870 hasAuthorship W1963807870A5035518209 @default.
• W1963807870 hasAuthorship W1963807870A5044366958 @default.
• W1963807870 hasAuthorship W1963807870A5063835480 @default.
• W1963807870 hasBestOaLocation W19638078701 @default.
• W1963807870 hasConcept C104177226 @default.
• W1963807870 hasConcept C104317684 @default.
• W1963807870 hasConcept C121608353 @default.
• W1963807870 hasConcept C128240485 @default.
• W1963807870 hasConcept C160450060 @default.
• W1963807870 hasConcept C170493617 @default.
• W1963807870 hasConcept C203014093 @default.
• W1963807870 hasConcept C2778690821 @default.
• W1963807870 hasConcept C2779256057 @default.
• W1963807870 hasConcept C502942594 @default.
• W1963807870 hasConcept C54355233 @default.
• W1963807870 hasConcept C555283112 @default.
• W1963807870 hasConcept C7876069 @default.
• W1963807870 hasConcept C81885089 @default.
• W1963807870 hasConcept C86803240 @default.
• W1963807870 hasConceptScore W1963807870C104177226 @default.
• W1963807870 hasConceptScore W1963807870C104317684 @default.
• W1963807870 hasConceptScore W1963807870C121608353 @default.
• W1963807870 hasConceptScore W1963807870C128240485 @default.
• W1963807870 hasConceptScore W1963807870C160450060 @default.
• W1963807870 hasConceptScore W1963807870C170493617 @default.
• W1963807870 hasConceptScore W1963807870C203014093 @default.

• next