FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963808393> ?p ?o ?g. }

• W1963808393 endingPage "86" @default.
• W1963808393 startingPage "75" @default.
• W1963808393 abstract "Previous reports from our laboratory have described short-latency contractions in muscles of the distal upper limb following stimulation of lower limb nerves or skin in persons with injury to the cervical spinal cord. It takes 6 or more months for interlimb reflexes (ILR) to appear following acute spinal cord injury (SCI), suggesting they might be due to new synaptic interconnections between lower limb sensory afferents and motoneurons in the cervical enlargement. In this study, we asked if once formed, the strength of these synaptic connections increased over time, a finding that would be consistent with the above hypothesis.We studied persons with sub-acute and/or chronic cervical SCI. ILR were elicited by brief trains of electrical pulses applied to the skin overlying the tibial nerve at the back of the knee. Responses were quantified based on their presence or absence in different upper limb muscles. We also generated peri-stimulus time histograms for single motor unit response latency, probability, and peak duration. Comparisons of these parameters were made in subjects at sub-acute versus chronic stages post-injury.In persons with sub-acute SCI, the probability of seeing ILR in a given muscle of the forearm or hand was low at first, but increased substantially over the next 1-2 years. Motor unit responses at this sub-acute stage had a prolonged and variable latency, with a lower absolute response probability, compared to findings from subjects with chronic (i.e. stable) SCI.Our findings demonstrate that interlimb reflex activity, once established after SCI, shows signs of strengthening synaptic contacts between afferent and efferent components, consistent with ongoing synaptic plasticity.Neurons within the adult human spinal cord caudal to a lesion site are not static, but appear to be capable of developing novel-yet highly efficacious-synaptic contacts following trauma-induced partial denervation. In this case, such contacts between ascending afferents and cervical motoneurons do not appear to provide any functional benefit to the subject. In fact their presence may limit the regenerative effort of supraspinal pathways which originally innervated these motoneurons, should effort in animal models to promote regeneration across the lesion epicenter be successfully translated to humans with chronic SCI." @default.
• W1963808393 created "2016-06-24" @default.
• W1963808393 creator A5002064250 @default.
• W1963808393 creator A5031138254 @default.
• W1963808393 creator A5042871936 @default.
• W1963808393 creator A5073702901 @default.
• W1963808393 date "2005-01-01" @default.
• W1963808393 modified "2023-09-23" @default.
• W1963808393 title "Interlimb reflex activity after spinal cord injury in man: strengthening response patterns are consistent with ongoing synaptic plasticity" @default.
• W1963808393 cites W1494081372 @default.
• W1963808393 cites W1501243786 @default.
• W1963808393 cites W1614786916 @default.
• W1963808393 cites W1903050514 @default.
• W1963808393 cites W1966222538 @default.
• W1963808393 cites W1966814296 @default.
• W1963808393 cites W1967380139 @default.
• W1963808393 cites W1970976264 @default.
• W1963808393 cites W1973130592 @default.
• W1963808393 cites W1983057945 @default.
• W1963808393 cites W1988576857 @default.
• W1963808393 cites W2006087095 @default.
• W1963808393 cites W2007840535 @default.
• W1963808393 cites W2012831867 @default.
• W1963808393 cites W2014467305 @default.
• W1963808393 cites W2014663730 @default.
• W1963808393 cites W2016378673 @default.
• W1963808393 cites W2016379224 @default.
• W1963808393 cites W2018070363 @default.
• W1963808393 cites W2021597976 @default.
• W1963808393 cites W2022117389 @default.
• W1963808393 cites W2026913937 @default.
• W1963808393 cites W2028803948 @default.
• W1963808393 cites W2032341534 @default.
• W1963808393 cites W2034386889 @default.
• W1963808393 cites W2038537583 @default.
• W1963808393 cites W2040322315 @default.
• W1963808393 cites W2048955450 @default.
• W1963808393 cites W2050057182 @default.
• W1963808393 cites W2050574220 @default.
• W1963808393 cites W2052545460 @default.
• W1963808393 cites W2055187509 @default.
• W1963808393 cites W2060118909 @default.
• W1963808393 cites W2061958917 @default.
• W1963808393 cites W2070825416 @default.
• W1963808393 cites W2071154283 @default.
• W1963808393 cites W2073863850 @default.
• W1963808393 cites W2074513619 @default.
• W1963808393 cites W2074640697 @default.
• W1963808393 cites W2075480483 @default.
• W1963808393 cites W2082092088 @default.
• W1963808393 cites W2093661293 @default.
• W1963808393 cites W2094068934 @default.
• W1963808393 cites W2100818287 @default.
• W1963808393 cites W2113186435 @default.
• W1963808393 cites W2116513009 @default.
• W1963808393 cites W2118465769 @default.
• W1963808393 cites W2124254448 @default.
• W1963808393 cites W2140271904 @default.
• W1963808393 cites W2142332662 @default.
• W1963808393 cites W2150278405 @default.
• W1963808393 cites W2168492324 @default.
• W1963808393 cites W2265704820 @default.
• W1963808393 cites W2319980664 @default.
• W1963808393 cites W2326705677 @default.
• W1963808393 cites W2331422553 @default.
• W1963808393 cites W2395443789 @default.
• W1963808393 cites W2418165004 @default.
• W1963808393 cites W2419857060 @default.
• W1963808393 cites W2469521770 @default.
• W1963808393 cites W4301870520 @default.
• W1963808393 doi "https://doi.org/10.1016/j.clinph.2004.07.018" @default.
• W1963808393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15589186" @default.
• W1963808393 hasPublicationYear "2005" @default.
• W1963808393 type Work @default.
• W1963808393 sameAs 1963808393 @default.
• W1963808393 citedByCount "43" @default.
• W1963808393 countsByYear W19638083932012 @default.
• W1963808393 countsByYear W19638083932013 @default.
• W1963808393 countsByYear W19638083932014 @default.
• W1963808393 countsByYear W19638083932015 @default.
• W1963808393 countsByYear W19638083932016 @default.
• W1963808393 countsByYear W19638083932017 @default.
• W1963808393 countsByYear W19638083932018 @default.
• W1963808393 countsByYear W19638083932019 @default.
• W1963808393 countsByYear W19638083932020 @default.
• W1963808393 countsByYear W19638083932021 @default.
• W1963808393 countsByYear W19638083932022 @default.
• W1963808393 crossrefType "journal-article" @default.
• W1963808393 hasAuthorship W1963808393A5002064250 @default.
• W1963808393 hasAuthorship W1963808393A5031138254 @default.
• W1963808393 hasAuthorship W1963808393A5042871936 @default.
• W1963808393 hasAuthorship W1963808393A5073702901 @default.
• W1963808393 hasConcept C105702510 @default.
• W1963808393 hasConcept C118552586 @default.
• W1963808393 hasConcept C126322002 @default.
• W1963808393 hasConcept C15744967 @default.
• W1963808393 hasConcept C169760540 @default.
• W1963808393 hasConcept C24998067 @default.

• next