FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963813826> ?p ?o ?g. }

• W1963813826 endingPage "268" @default.
• W1963813826 startingPage "260" @default.
• W1963813826 abstract "To study the effect of a continuous cyclic mechanical load on the release of newly synthesized proteoglycans (PGs) from mature bovine articular cartilage.Viable cartilage explants were continuously loaded with 1 MPa cyclic stress at 1 Hz frequency for 24 h, and the release of labeled (35SO4) PGs measured before, during and after application of the compressive load. To separate the effect of active chondrocyte catabolism from that of passive PG release, PG release in live explants, with and without protease inhibitors to inhibit PG breakdown, was compared to PG release in explants whose chondrocytes were killed prior to loading.In live explants, a continuous cyclic load significantly reduced PG release by as much as 50% compared to unloaded explants. In killed explants which were unloaded, the PG release increased five to 10 times, while a cyclic load reduced PG release to that found in viable, loaded explants. Twenty-four hours after load removal PG release in all loaded explants returned (increased) to that of the unloaded explants.These results indicate that PG release from the cartilage matrix is inhibited by continuous cyclic mechanical loading, independent of cellular metabolism, and suggest that a primary mechanism for reducing PG release is by decreasing the interstitial porosity through which the PGs can escape." @default.
• W1963813826 created "2016-06-24" @default.
• W1963813826 creator A5001897843 @default.
• W1963813826 creator A5006182021 @default.
• W1963813826 date "1998-07-01" @default.
• W1963813826 modified "2023-10-14" @default.
• W1963813826 title "Continuous cyclic load reduces proteoglycan release from articular cartilage" @default.
• W1963813826 cites W1512133698 @default.
• W1963813826 cites W1572176725 @default.
• W1963813826 cites W1965821379 @default.
• W1963813826 cites W1972662716 @default.
• W1963813826 cites W1974865492 @default.
• W1963813826 cites W1982327214 @default.
• W1963813826 cites W2001371507 @default.
• W1963813826 cites W2009350275 @default.
• W1963813826 cites W2026085057 @default.
• W1963813826 cites W2033625161 @default.
• W1963813826 cites W2048021515 @default.
• W1963813826 cites W2057198306 @default.
• W1963813826 cites W2062985572 @default.
• W1963813826 cites W2065802157 @default.
• W1963813826 cites W2070622848 @default.
• W1963813826 cites W2079487344 @default.
• W1963813826 cites W2126843316 @default.
• W1963813826 cites W2141678715 @default.
• W1963813826 cites W2147526125 @default.
• W1963813826 cites W2154208787 @default.
• W1963813826 cites W2161153046 @default.
• W1963813826 cites W2167125699 @default.
• W1963813826 cites W2410773019 @default.
• W1963813826 cites W2419288771 @default.
• W1963813826 cites W69923272 @default.
• W1963813826 cites W90346617 @default.
• W1963813826 doi "https://doi.org/10.1053/joca.1998.0119" @default.
• W1963813826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9876395" @default.
• W1963813826 hasPublicationYear "1998" @default.
• W1963813826 type Work @default.
• W1963813826 sameAs 1963813826 @default.
• W1963813826 citedByCount "37" @default.
• W1963813826 countsByYear W19638138262016 @default.
• W1963813826 countsByYear W19638138262017 @default.
• W1963813826 countsByYear W19638138262018 @default.
• W1963813826 countsByYear W19638138262019 @default.
• W1963813826 countsByYear W19638138262020 @default.
• W1963813826 countsByYear W19638138262021 @default.
• W1963813826 countsByYear W19638138262022 @default.
• W1963813826 crossrefType "journal-article" @default.
• W1963813826 hasAuthorship W1963813826A5001897843 @default.
• W1963813826 hasAuthorship W1963813826A5006182021 @default.
• W1963813826 hasBestOaLocation W19638138261 @default.
• W1963813826 hasConcept C105702510 @default.
• W1963813826 hasConcept C12554922 @default.
• W1963813826 hasConcept C142724271 @default.
• W1963813826 hasConcept C157890192 @default.
• W1963813826 hasConcept C163588942 @default.
• W1963813826 hasConcept C185592680 @default.
• W1963813826 hasConcept C189165786 @default.
• W1963813826 hasConcept C202751555 @default.
• W1963813826 hasConcept C204787440 @default.
• W1963813826 hasConcept C2776164576 @default.
• W1963813826 hasConcept C2779335624 @default.
• W1963813826 hasConcept C2780550940 @default.
• W1963813826 hasConcept C2781403057 @default.
• W1963813826 hasConcept C3020332539 @default.
• W1963813826 hasConcept C55493867 @default.
• W1963813826 hasConcept C62231903 @default.
• W1963813826 hasConcept C71924100 @default.
• W1963813826 hasConcept C86803240 @default.
• W1963813826 hasConcept C96942376 @default.
• W1963813826 hasConcept C98274493 @default.
• W1963813826 hasConceptScore W1963813826C105702510 @default.
• W1963813826 hasConceptScore W1963813826C12554922 @default.
• W1963813826 hasConceptScore W1963813826C142724271 @default.
• W1963813826 hasConceptScore W1963813826C157890192 @default.
• W1963813826 hasConceptScore W1963813826C163588942 @default.
• W1963813826 hasConceptScore W1963813826C185592680 @default.
• W1963813826 hasConceptScore W1963813826C189165786 @default.
• W1963813826 hasConceptScore W1963813826C202751555 @default.
• W1963813826 hasConceptScore W1963813826C204787440 @default.
• W1963813826 hasConceptScore W1963813826C2776164576 @default.
• W1963813826 hasConceptScore W1963813826C2779335624 @default.
• W1963813826 hasConceptScore W1963813826C2780550940 @default.
• W1963813826 hasConceptScore W1963813826C2781403057 @default.
• W1963813826 hasConceptScore W1963813826C3020332539 @default.
• W1963813826 hasConceptScore W1963813826C55493867 @default.
• W1963813826 hasConceptScore W1963813826C62231903 @default.
• W1963813826 hasConceptScore W1963813826C71924100 @default.
• W1963813826 hasConceptScore W1963813826C86803240 @default.
• W1963813826 hasConceptScore W1963813826C96942376 @default.
• W1963813826 hasConceptScore W1963813826C98274493 @default.
• W1963813826 hasIssue "4" @default.
• W1963813826 hasLocation W19638138261 @default.
• W1963813826 hasLocation W19638138262 @default.
• W1963813826 hasOpenAccess W1963813826 @default.
• W1963813826 hasPrimaryLocation W19638138261 @default.
• W1963813826 hasRelatedWork W1891049472 @default.
• W1963813826 hasRelatedWork W1963813826 @default.
• W1963813826 hasRelatedWork W1987301197 @default.

• next