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• W1963813865 abstract "Black flies are known to be vectors of pathogens including Onchocerca volvulus, which causes human onchocerciasis, and Vesicular Stomatitis Virus. Their salivary secretion has been shown to contain a complex cocktail of anti-haemostatic factors and immunomodulatory activities, which may contribute to efficient transmission of the pathogens. Black fly salivary gland extract (SGE) inhibits mitogen-stimulated mouse splenocyte proliferation, including proliferation of both CD4+ and CD8+ T cells. The factor responsible for the inhibition was determined to be a protein (or protein complex) of a size larger than 50 kDa. Moreover, exposure to SGE results in activation of caspase 3 and characteristic morphological changes in CD4+ and CD8+ T cells, suggesting that induction of apoptosis could, at least in part, be responsible for this inhibition." @default.
• W1963813865 created "2016-06-24" @default.
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• W1963813865 date "2010-04-01" @default.
• W1963813865 modified "2023-10-10" @default.
• W1963813865 title "Black fly salivary gland extract inhibits proliferation and induces apoptosis in murine splenocytes" @default.
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• W1963813865 doi "https://doi.org/10.1111/j.1365-3024.2009.01186.x" @default.
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