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• W1963821124 abstract "Background: The proportion of people with HIV-1 infection who have coexisting type 2 diabetes mellitus (DM) is increasing. The higher incidence of type 2 DM in this patient population is associated with increased survival from HIV-1 infection due to advanced HIV treatment strategies and therapies, as well as a complex interaction of diabetes risk factors, including family history, body composition, comorbidities, HIV treatment modality, and disease progression. Objective: The purpose of this article was to describe the impact of these contributing factors on the risk for type 2 DM among people with HIV-1 infection and the available treatment options for managing type 2 DM in these patients. Methods: The Ovid MEDLINE database was searched for English language articles published between January 2005 and June 2009. Various search strategies were applied to identify appropriate articles. The references listed in the retrieved documents were searched for additional articles. Nonhuman studies were excluded. Results: Abnormal glucose homeostasis and metabolic disturbances associated with HIV-1 infection appear to have become widespread after the introduction and application of potent antiretroviral therapy, including protease inhibitors (PIs), ritonavir-boosted PIs, nucleoside reverse transcriptase inhibitors (NRTIs), and nonnucleoside reverse transcriptase inhibitors (NNRTIs). PIs and NNRTIs may have pathogenic roles in insulin resistance, whereas the stage and progression of HIV-1 infection affect lipid values and glucose homeostasis. It is estimated that as many as 80% of patients currently treated with PIs develop insulin resistance compared with ~2% before the introduction of highly active antiretroviral therapy. Evidence suggests that statins may be contraindicated as a combination therapy with PIs when comanaging dyslipidemia and HIV-1 infection. Pharmacotherapy for HIV-1 infection must be monitored closely for its impact on patients' metabolic and cardiovascular systems, and necessary modifications made while monitoring and maintaining the stability of the viral load. Conclusions: The metabolic effects of combination therapies for HIV infection, including PIs, ritonavir-boosted PIs, NRTIs, and NNRTIs, appear to increase the risk for insulin resistance, type 2 DM, and poor cardiovascular disease outcomes. Because of differences in the pharmacokinetic properties between statins and PIs, it is critical for clinicians to properly manage combination antiretroviral therapy, as well as pharmacotherapy for DM and dyslipidemia, when managing patients with HIV-1 infection and insulin resistance. Clinicians must consider the stage of HIV disease and the demographic characteristics of patients with these comorbid diseases, both of which require careful attention to medical management, pharmacotherapy, and patient adherence to treatment recommendations." @default.
• W1963821124 created "2016-06-24" @default.
• W1963821124 creator A5053193782 @default.
• W1963821124 date "2010-01-01" @default.
• W1963821124 modified "2023-09-27" @default.
• W1963821124 title "Increased risk for type 2 diabetes mellitus with HIV-1 infection" @default.
• W1963821124 cites W1426208733 @default.
• W1963821124 cites W1485194246 @default.
• W1963821124 cites W1573777285 @default.
• W1963821124 cites W1961682665 @default.
• W1963821124 cites W1964054283 @default.
• W1963821124 cites W1967696639 @default.
• W1963821124 cites W1973775519 @default.
• W1963821124 cites W1983335996 @default.
• W1963821124 cites W1986281714 @default.
• W1963821124 cites W1987491896 @default.
• W1963821124 cites W1989669356 @default.
• W1963821124 cites W1990006539 @default.
• W1963821124 cites W1991792215 @default.
• W1963821124 cites W1999140098 @default.
• W1963821124 cites W2002615726 @default.
• W1963821124 cites W2003358339 @default.
• W1963821124 cites W2013255079 @default.
• W1963821124 cites W2013541138 @default.
• W1963821124 cites W2015473003 @default.
• W1963821124 cites W2015499276 @default.
• W1963821124 cites W2019539951 @default.
• W1963821124 cites W2019802991 @default.
• W1963821124 cites W2020445344 @default.
• W1963821124 cites W2022225339 @default.
• W1963821124 cites W2025721425 @default.
• W1963821124 cites W2028657303 @default.
• W1963821124 cites W2038543613 @default.
• W1963821124 cites W2043427266 @default.
• W1963821124 cites W2044139946 @default.
• W1963821124 cites W2050145918 @default.
• W1963821124 cites W2055081887 @default.
• W1963821124 cites W2056780685 @default.
• W1963821124 cites W2058296924 @default.
• W1963821124 cites W2059265320 @default.
• W1963821124 cites W2059943637 @default.
• W1963821124 cites W2060210361 @default.
• W1963821124 cites W2063244503 @default.
• W1963821124 cites W2070032624 @default.
• W1963821124 cites W2071571021 @default.
• W1963821124 cites W2073738273 @default.
• W1963821124 cites W2074185284 @default.
• W1963821124 cites W2080507282 @default.
• W1963821124 cites W2080660922 @default.
• W1963821124 cites W2081299887 @default.
• W1963821124 cites W2083167945 @default.
• W1963821124 cites W2090939611 @default.
• W1963821124 cites W2092195709 @default.
• W1963821124 cites W2100514340 @default.
• W1963821124 cites W2107014597 @default.
• W1963821124 cites W2107198204 @default.
• W1963821124 cites W2108207542 @default.
• W1963821124 cites W2110020655 @default.
• W1963821124 cites W2110717475 @default.
• W1963821124 cites W2123420731 @default.
• W1963821124 cites W2124073607 @default.
• W1963821124 cites W2136162563 @default.
• W1963821124 cites W2138652733 @default.
• W1963821124 cites W2151701113 @default.
• W1963821124 cites W2156498401 @default.
• W1963821124 cites W2157115138 @default.
• W1963821124 cites W2157138119 @default.
• W1963821124 cites W2159584933 @default.
• W1963821124 cites W2161795936 @default.
• W1963821124 cites W2166168319 @default.
• W1963821124 cites W2168962808 @default.
• W1963821124 cites W2170821252 @default.
• W1963821124 cites W2171628116 @default.
• W1963821124 cites W2182777591 @default.
• W1963821124 cites W2316412239 @default.
• W1963821124 cites W2323903984 @default.
• W1963821124 cites W3146895267 @default.
• W1963821124 cites W4240353985 @default.
• W1963821124 cites W4240611148 @default.
• W1963821124 cites W4245367233 @default.
• W1963821124 cites W4249862680 @default.
• W1963821124 cites W4255744991 @default.
• W1963821124 cites W4296391115 @default.
• W1963821124 cites W82537579 @default.
• W1963821124 doi "https://doi.org/10.1016/s1557-0843(10)80008-9" @default.
• W1963821124 hasPublicationYear "2010" @default.
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