Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963828713> ?p ?o ?g. }
- W1963828713 endingPage "6974" @default.
- W1963828713 startingPage "6969" @default.
- W1963828713 abstract "This study completes a series of papers devoted to the characterization of the non-competitive mGluR2/3 antagonist properties of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives with particular emphasis on derivatizations compatible with brain penetration and in vivo activity. Especially the compounds bearing a para-pyridine consistently showed in vivo activity in rat behavioral models after oral administration, for example, blockade of the mGluR2/3 agonist LY354740-induced hypoactivity and improvement of a working memory deficit induced either by LY354740 or scopolamine in the delayed match to position task (DMTP). Moreover, combination studies with a cholinesterase inhibitor show apparent synergistic effects on working memory impairment induced by scopolamine." @default.
- W1963828713 created "2016-06-24" @default.
- W1963828713 creator A5001344172 @default.
- W1963828713 creator A5004941560 @default.
- W1963828713 creator A5023853048 @default.
- W1963828713 creator A5024537963 @default.
- W1963828713 creator A5043099099 @default.
- W1963828713 creator A5085627326 @default.
- W1963828713 creator A5087393240 @default.
- W1963828713 date "2010-12-01" @default.
- W1963828713 modified "2023-10-16" @default.
- W1963828713 title "Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists" @default.
- W1963828713 cites W1966867970 @default.
- W1963828713 cites W1980556441 @default.
- W1963828713 cites W2012199810 @default.
- W1963828713 cites W2018436424 @default.
- W1963828713 cites W2019110706 @default.
- W1963828713 cites W2019353857 @default.
- W1963828713 cites W2032420952 @default.
- W1963828713 cites W2040258322 @default.
- W1963828713 cites W2062458432 @default.
- W1963828713 cites W2066930393 @default.
- W1963828713 cites W2072471087 @default.
- W1963828713 cites W2074907255 @default.
- W1963828713 cites W2120307371 @default.
- W1963828713 cites W4236973976 @default.
- W1963828713 doi "https://doi.org/10.1016/j.bmcl.2010.09.125" @default.
- W1963828713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20971004" @default.
- W1963828713 hasPublicationYear "2010" @default.
- W1963828713 type Work @default.
- W1963828713 sameAs 1963828713 @default.
- W1963828713 citedByCount "38" @default.
- W1963828713 countsByYear W19638287132012 @default.
- W1963828713 countsByYear W19638287132013 @default.
- W1963828713 countsByYear W19638287132014 @default.
- W1963828713 countsByYear W19638287132015 @default.
- W1963828713 countsByYear W19638287132016 @default.
- W1963828713 countsByYear W19638287132017 @default.
- W1963828713 countsByYear W19638287132019 @default.
- W1963828713 countsByYear W19638287132020 @default.
- W1963828713 countsByYear W19638287132021 @default.
- W1963828713 countsByYear W19638287132022 @default.
- W1963828713 countsByYear W19638287132023 @default.
- W1963828713 crossrefType "journal-article" @default.
- W1963828713 hasAuthorship W1963828713A5001344172 @default.
- W1963828713 hasAuthorship W1963828713A5004941560 @default.
- W1963828713 hasAuthorship W1963828713A5023853048 @default.
- W1963828713 hasAuthorship W1963828713A5024537963 @default.
- W1963828713 hasAuthorship W1963828713A5043099099 @default.
- W1963828713 hasAuthorship W1963828713A5085627326 @default.
- W1963828713 hasAuthorship W1963828713A5087393240 @default.
- W1963828713 hasConcept C119128870 @default.
- W1963828713 hasConcept C150903083 @default.
- W1963828713 hasConcept C15744967 @default.
- W1963828713 hasConcept C169760540 @default.
- W1963828713 hasConcept C170493617 @default.
- W1963828713 hasConcept C185592680 @default.
- W1963828713 hasConcept C207001950 @default.
- W1963828713 hasConcept C26702167 @default.
- W1963828713 hasConcept C2776885963 @default.
- W1963828713 hasConcept C2778938600 @default.
- W1963828713 hasConcept C2779424989 @default.
- W1963828713 hasConcept C31896038 @default.
- W1963828713 hasConcept C49051014 @default.
- W1963828713 hasConcept C55493867 @default.
- W1963828713 hasConcept C71240020 @default.
- W1963828713 hasConcept C71924100 @default.
- W1963828713 hasConcept C86803240 @default.
- W1963828713 hasConcept C98274493 @default.
- W1963828713 hasConceptScore W1963828713C119128870 @default.
- W1963828713 hasConceptScore W1963828713C150903083 @default.
- W1963828713 hasConceptScore W1963828713C15744967 @default.
- W1963828713 hasConceptScore W1963828713C169760540 @default.
- W1963828713 hasConceptScore W1963828713C170493617 @default.
- W1963828713 hasConceptScore W1963828713C185592680 @default.
- W1963828713 hasConceptScore W1963828713C207001950 @default.
- W1963828713 hasConceptScore W1963828713C26702167 @default.
- W1963828713 hasConceptScore W1963828713C2776885963 @default.
- W1963828713 hasConceptScore W1963828713C2778938600 @default.
- W1963828713 hasConceptScore W1963828713C2779424989 @default.
- W1963828713 hasConceptScore W1963828713C31896038 @default.
- W1963828713 hasConceptScore W1963828713C49051014 @default.
- W1963828713 hasConceptScore W1963828713C55493867 @default.
- W1963828713 hasConceptScore W1963828713C71240020 @default.
- W1963828713 hasConceptScore W1963828713C71924100 @default.
- W1963828713 hasConceptScore W1963828713C86803240 @default.
- W1963828713 hasConceptScore W1963828713C98274493 @default.
- W1963828713 hasIssue "23" @default.
- W1963828713 hasLocation W19638287131 @default.
- W1963828713 hasLocation W19638287132 @default.
- W1963828713 hasOpenAccess W1963828713 @default.
- W1963828713 hasPrimaryLocation W19638287131 @default.
- W1963828713 hasRelatedWork W1509785349 @default.
- W1963828713 hasRelatedWork W1563212190 @default.
- W1963828713 hasRelatedWork W1968412099 @default.
- W1963828713 hasRelatedWork W2028152919 @default.
- W1963828713 hasRelatedWork W2135907238 @default.
- W1963828713 hasRelatedWork W2165288993 @default.