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- W1963833457 abstract "The effect of intravenous infusion of adrenocorticotrophic hormone (ACTH) (12u/h) on the adrenal venous concentration of adenosine 3'5' cyclic monophosphate (c-AMP) was studied in five conscious sheep with a cervical adrenal autotransplant. In addition adrenal vein blood was assayed for cortisol, corticosterone and aldosterone. ACTH infusion caused a rapid increase in adrenal c-AMP output which was apparent within the first minute of infusion and which appeared to precede the increase in steroid production. Peak c-AMP output was 10–100 fold greater than pre-infusion output and was reached within 15 min of infusion. Maximum steroid production also occurred at about 15 min. However, in contrast to adrenal steroid production, the increase in adrenal c-AMP output was not sustained at the maximum rate and decreased gradually during the infusion period. In sheep with maximum pre-infusion steroid production, adrenal c-AMP output was increased by ACTH infusion. The basal c-AMP concentration in arterial plasma was 10–35 nM and no significant increase was observed during ACTH infusion. The response pattern of c-AMP and steroid secretion by the adrenal gland in vivo to a large dose of ACTH confirms that previously reported from in vitro studies." @default.
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- W1963833457 date "1976-04-01" @default.
- W1963833457 modified "2023-09-27" @default.
- W1963833457 title "Effect of adrenocorticotrophic hormone on the in vivo output of adenosine 3'5' cyclic monophosphate and corticosteroids by the sheep adrenal gland" @default.
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- W1963833457 doi "https://doi.org/10.1016/0022-4731(76)90121-7" @default.
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