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• W1963836043 abstract "Hedgehog (Hh) acts as a morphogen to activate the transcription of diverse target genes via its downstream effector Cubitus interruptus (Ci). Currently, it is less understood how Ci recruits co-factors to activate transcription. Here we report that hyperplastic discs (hyd), an E3 ubiquitin ligase, can differentially regulate the transcriptional outputs of Hh signaling. We show that loss of Hyd activity caused upregulation of some, but not all of Hh target genes. Importantly, Hyd does not affect the stability of Ci. Our data suggest that Hyd differentially restrains the transcriptional activity of Ci via selective association with respective promoters." @default.
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• W1963836043 date "2014-08-01" @default.
• W1963836043 modified "2023-10-16" @default.
• W1963836043 title "Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signaling" @default.
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• W1963836043 doi "https://doi.org/10.1016/j.mod.2014.05.002" @default.
• W1963836043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4351657" @default.
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