FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963843762> ?p ?o ?g. }

• W1963843762 endingPage "150" @default.
• W1963843762 startingPage "145" @default.
• W1963843762 abstract "The anticancer agent 3-aminopyridine-2-carboxaldehyde thiosemicarbazone is a ribonucleotide reductase inhibitor. It inactivates ribonucleotide reductase by disrupting an iron-stabilized radical in ribonucleotide reductase’s small subunits, M2 and M2b (p53R2). Unfortunately, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone also alters iron II (Fe 2+ ) in hemoglobin. This creates Fe 3+ methemoglobin that does not deliver oxygen. Fe 2+ in hemoglobin normally auto-oxidizes to inactive Fe 3+ methemoglobin at a rate of nearly 3% per day and this is counterbalanced by a reductase system that normally limits methemoglobin concentrations to less than 1% of hemoglobin. This balance may be perturbed by symptomatic toxicity levels during 3-aminopyridine-2-carboxaldehyde thiosemicarbazone therapy. Indications of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone sequelae attributable to methemoglobinemia include resting dyspnea, headaches and altered cognition. Management of methemoglobinemia includes supplemental oxygen, ascorbate and, most importantly, intravenously administered methylene blue as a therapeutic antidote." @default.
• W1963843762 created "2016-06-24" @default.
• W1963843762 creator A5018406749 @default.
• W1963843762 creator A5042269391 @default.
• W1963843762 creator A5063050485 @default.
• W1963843762 creator A5063314967 @default.
• W1963843762 date "2012-02-01" @default.
• W1963843762 modified "2023-10-15" @default.
• W1963843762 title "Management of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone-induced methemoglobinemia" @default.
• W1963843762 cites W1510505825 @default.
• W1963843762 cites W1680634601 @default.
• W1963843762 cites W1943436674 @default.
• W1963843762 cites W1967830103 @default.
• W1963843762 cites W1988892257 @default.
• W1963843762 cites W1999537037 @default.
• W1963843762 cites W2009486080 @default.
• W1963843762 cites W2013015071 @default.
• W1963843762 cites W2017024085 @default.
• W1963843762 cites W2019166334 @default.
• W1963843762 cites W2055810949 @default.
• W1963843762 cites W2069112297 @default.
• W1963843762 cites W2083315452 @default.
• W1963843762 cites W2085972813 @default.
• W1963843762 cites W2087293823 @default.
• W1963843762 cites W2089440451 @default.
• W1963843762 cites W2089876863 @default.
• W1963843762 cites W2103041841 @default.
• W1963843762 cites W2113765255 @default.
• W1963843762 cites W2118226539 @default.
• W1963843762 cites W2166913012 @default.
• W1963843762 cites W2178778111 @default.
• W1963843762 cites W2303733864 @default.
• W1963843762 cites W4242743693 @default.
• W1963843762 cites W96484744 @default.
• W1963843762 doi "https://doi.org/10.2217/fon.11.147" @default.
• W1963843762 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3292053" @default.
• W1963843762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22335579" @default.
• W1963843762 hasPublicationYear "2012" @default.
• W1963843762 type Work @default.
• W1963843762 sameAs 1963843762 @default.
• W1963843762 citedByCount "23" @default.
• W1963843762 countsByYear W19638437622013 @default.
• W1963843762 countsByYear W19638437622014 @default.
• W1963843762 countsByYear W19638437622015 @default.
• W1963843762 countsByYear W19638437622016 @default.
• W1963843762 countsByYear W19638437622018 @default.
• W1963843762 countsByYear W19638437622019 @default.
• W1963843762 countsByYear W19638437622020 @default.
• W1963843762 countsByYear W19638437622021 @default.
• W1963843762 countsByYear W19638437622022 @default.
• W1963843762 crossrefType "journal-article" @default.
• W1963843762 hasAuthorship W1963843762A5018406749 @default.
• W1963843762 hasAuthorship W1963843762A5042269391 @default.
• W1963843762 hasAuthorship W1963843762A5063050485 @default.
• W1963843762 hasAuthorship W1963843762A5063314967 @default.
• W1963843762 hasBestOaLocation W19638437622 @default.
• W1963843762 hasConcept C104292427 @default.
• W1963843762 hasConcept C104317684 @default.
• W1963843762 hasConcept C126322002 @default.
• W1963843762 hasConcept C161790260 @default.
• W1963843762 hasConcept C185592680 @default.
• W1963843762 hasConcept C26865036 @default.
• W1963843762 hasConcept C2777737778 @default.
• W1963843762 hasConcept C2778917026 @default.
• W1963843762 hasConcept C2779191827 @default.
• W1963843762 hasConcept C42219234 @default.
• W1963843762 hasConcept C4710235 @default.
• W1963843762 hasConcept C55493867 @default.
• W1963843762 hasConcept C65165184 @default.
• W1963843762 hasConcept C71924100 @default.
• W1963843762 hasConcept C98274493 @default.
• W1963843762 hasConceptScore W1963843762C104292427 @default.
• W1963843762 hasConceptScore W1963843762C104317684 @default.
• W1963843762 hasConceptScore W1963843762C126322002 @default.
• W1963843762 hasConceptScore W1963843762C161790260 @default.
• W1963843762 hasConceptScore W1963843762C185592680 @default.
• W1963843762 hasConceptScore W1963843762C26865036 @default.
• W1963843762 hasConceptScore W1963843762C2777737778 @default.
• W1963843762 hasConceptScore W1963843762C2778917026 @default.
• W1963843762 hasConceptScore W1963843762C2779191827 @default.
• W1963843762 hasConceptScore W1963843762C42219234 @default.
• W1963843762 hasConceptScore W1963843762C4710235 @default.
• W1963843762 hasConceptScore W1963843762C55493867 @default.
• W1963843762 hasConceptScore W1963843762C65165184 @default.
• W1963843762 hasConceptScore W1963843762C71924100 @default.
• W1963843762 hasConceptScore W1963843762C98274493 @default.
• W1963843762 hasIssue "2" @default.
• W1963843762 hasLocation W19638437621 @default.
• W1963843762 hasLocation W19638437622 @default.
• W1963843762 hasLocation W19638437623 @default.
• W1963843762 hasLocation W19638437624 @default.
• W1963843762 hasOpenAccess W1963843762 @default.
• W1963843762 hasPrimaryLocation W19638437621 @default.
• W1963843762 hasRelatedWork W1517982398 @default.
• W1963843762 hasRelatedWork W1865456213 @default.
• W1963843762 hasRelatedWork W1954423156 @default.
• W1963843762 hasRelatedWork W1963843762 @default.
• W1963843762 hasRelatedWork W2021458221 @default.

• next