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- W1963846263 abstract "Neuroimaging assessment of amyloid plaque and of non-specific neuronal dysfunction (for example as seen in FDG images) may be complementary in the evaluation of neurodegenerative disorders. We explored whether data from the first 5 min after Florbetapir injection could be used as a surrogate marker of regional cerebral blood flow (rCBF) and assessed the degree to which these images concurred with FDG images of cerebral glucose metabolism (rCGM) in the same subjects. Florbetapir and FDG images from ADNI2 were analyzed for 77 subjects (8 Alzheimer's Disease, 16 Mild Cognitive Impairment, 32 subjective memory complaints and 21 cognitively normal). Subjects had a dynamic florbetapir PET acquisition from 0-20 min after injection and on a separate day underwent an FDG scan starting 30 min after injection. Integrated images of the first 5 min of scanning were created for Florbetapir using a trapezoidal method. After normalization to MNI space, whole-brain normalized estimated rCBF area under the curve (AUC) and rCGM values were calculated for Florbetapir and FDG images respectively. Correlation analysis was performed between FDG and florbetapir data from neocortical ROIs and on a voxel-wise basis. Also, Neurostat was employed to compare rCBF Florbetapir images and FDG images to a normal FDG database. For ROI analyses, the average correlation r value was 0.91 with an average slope of 0.81. For voxel-wise correlations, the average r value was 0.84 and the average slope was 0.78. Visual inspection of the “rCBF”/rCGM image pairs revealed substantial concordance among areas of both normal and reduced neuronal metabolism. Neurostat database comparisons also revealed substantial agreement between rCBF and rCGM image pairs." @default.
- W1963846263 created "2016-06-24" @default.
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- W1963846263 date "2014-07-01" @default.
- W1963846263 modified "2023-10-16" @default.
- W1963846263 title "IC-P-183: EMPLOYING EARLY UPTAKE DATA FROM F18-FLORBETAPIR SCANS AS AN ESTIMATE OF REGIONAL CEREBRAL BLOOD FLOW: COMPARISON TO F18-FDG" @default.
- W1963846263 doi "https://doi.org/10.1016/j.jalz.2014.05.190" @default.
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