Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963854339> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1963854339 endingPage "488" @default.
- W1963854339 startingPage "481" @default.
- W1963854339 abstract "A monoclonal antibody termed NC-1 was produced which binds to an antigen present on the human promyelocytic leukemia cell line HL-60 and peripheral blood neutrophils. The antibody bound to the majority of promyelocytes in the HL-60 culture, but not to myeloblasts. No antibody reactivity was detected to a range of other cell lines or to a limited number of normal human tissues. Peripheral blood lymphocytes, monocytes, basophils, eosinophils, erythrocytes and platelets did not react with the antibody. Bone marrow smears exhibited binding of NC-1 to myeloid cells at the promyelocyte and later stages of differentiation along the granulocyte lineage. The KG-1 myeloblastoid and U937 myelomonocytic lines could be induced to express the antigen, when exposed to neuraminidase which removes terminal sialic acid from carbohydrate residues. Similarly myeloblasts in bone marrow samples bound NC-1 when they were treated with neuraminidase. HL-60 cells induced to differentiate to granulocytes by treatment with retinoic acid continued to express the antigen. A similar result was observed when HL-60 cells were induced to differentiate to monocytes, even though blood monocytes failed to bind the antibody. These data indicate that the antibody NC-1 reacts with an antigen expressed on myeloid cells beyond the promyelocyte stage of differentiation." @default.
- W1963854339 created "2016-06-24" @default.
- W1963854339 creator A5005360775 @default.
- W1963854339 creator A5015274946 @default.
- W1963854339 creator A5019802706 @default.
- W1963854339 creator A5019927437 @default.
- W1963854339 date "1987-01-01" @default.
- W1963854339 modified "2023-09-27" @default.
- W1963854339 title "Production and characterization of a monoclonal antibody to a myeloid specific differentiation antigen" @default.
- W1963854339 cites W124268133 @default.
- W1963854339 cites W130020229 @default.
- W1963854339 cites W1489850871 @default.
- W1963854339 cites W1565400131 @default.
- W1963854339 cites W1595956153 @default.
- W1963854339 cites W1763097249 @default.
- W1963854339 cites W1921676257 @default.
- W1963854339 cites W1968028322 @default.
- W1963854339 cites W1973279944 @default.
- W1963854339 cites W1975738323 @default.
- W1963854339 cites W1995127270 @default.
- W1963854339 cites W1999689481 @default.
- W1963854339 cites W2032819570 @default.
- W1963854339 cites W2047931302 @default.
- W1963854339 cites W2054091854 @default.
- W1963854339 cites W2065861447 @default.
- W1963854339 cites W2133764756 @default.
- W1963854339 cites W2255440074 @default.
- W1963854339 cites W2398093429 @default.
- W1963854339 cites W2418652444 @default.
- W1963854339 cites W92934419 @default.
- W1963854339 doi "https://doi.org/10.1016/0145-2126(87)90081-6" @default.
- W1963854339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3472018" @default.
- W1963854339 hasPublicationYear "1987" @default.
- W1963854339 type Work @default.
- W1963854339 sameAs 1963854339 @default.
- W1963854339 citedByCount "2" @default.
- W1963854339 crossrefType "journal-article" @default.
- W1963854339 hasAuthorship W1963854339A5005360775 @default.
- W1963854339 hasAuthorship W1963854339A5015274946 @default.
- W1963854339 hasAuthorship W1963854339A5019802706 @default.
- W1963854339 hasAuthorship W1963854339A5019927437 @default.
- W1963854339 hasConcept C109159458 @default.
- W1963854339 hasConcept C119157973 @default.
- W1963854339 hasConcept C147483822 @default.
- W1963854339 hasConcept C153911025 @default.
- W1963854339 hasConcept C159654299 @default.
- W1963854339 hasConcept C185592680 @default.
- W1963854339 hasConcept C203014093 @default.
- W1963854339 hasConcept C2777983669 @default.
- W1963854339 hasConcept C2778461978 @default.
- W1963854339 hasConcept C2779282312 @default.
- W1963854339 hasConcept C2780007613 @default.
- W1963854339 hasConcept C2781184567 @default.
- W1963854339 hasConcept C28328180 @default.
- W1963854339 hasConcept C542903549 @default.
- W1963854339 hasConcept C86803240 @default.
- W1963854339 hasConcept C95444343 @default.
- W1963854339 hasConcept C95862172 @default.
- W1963854339 hasConceptScore W1963854339C109159458 @default.
- W1963854339 hasConceptScore W1963854339C119157973 @default.
- W1963854339 hasConceptScore W1963854339C147483822 @default.
- W1963854339 hasConceptScore W1963854339C153911025 @default.
- W1963854339 hasConceptScore W1963854339C159654299 @default.
- W1963854339 hasConceptScore W1963854339C185592680 @default.
- W1963854339 hasConceptScore W1963854339C203014093 @default.
- W1963854339 hasConceptScore W1963854339C2777983669 @default.
- W1963854339 hasConceptScore W1963854339C2778461978 @default.
- W1963854339 hasConceptScore W1963854339C2779282312 @default.
- W1963854339 hasConceptScore W1963854339C2780007613 @default.
- W1963854339 hasConceptScore W1963854339C2781184567 @default.
- W1963854339 hasConceptScore W1963854339C28328180 @default.
- W1963854339 hasConceptScore W1963854339C542903549 @default.
- W1963854339 hasConceptScore W1963854339C86803240 @default.
- W1963854339 hasConceptScore W1963854339C95444343 @default.
- W1963854339 hasConceptScore W1963854339C95862172 @default.
- W1963854339 hasIssue "5" @default.
- W1963854339 hasLocation W19638543391 @default.
- W1963854339 hasLocation W19638543392 @default.
- W1963854339 hasOpenAccess W1963854339 @default.
- W1963854339 hasPrimaryLocation W19638543391 @default.
- W1963854339 hasRelatedWork W1671298126 @default.
- W1963854339 hasRelatedWork W1976032628 @default.
- W1963854339 hasRelatedWork W2015471476 @default.
- W1963854339 hasRelatedWork W2017320131 @default.
- W1963854339 hasRelatedWork W2102345516 @default.
- W1963854339 hasRelatedWork W2156609342 @default.
- W1963854339 hasRelatedWork W2286906990 @default.
- W1963854339 hasRelatedWork W2437651174 @default.
- W1963854339 hasRelatedWork W4235682420 @default.
- W1963854339 hasRelatedWork W3143809607 @default.
- W1963854339 hasVolume "11" @default.
- W1963854339 isParatext "false" @default.
- W1963854339 isRetracted "false" @default.
- W1963854339 magId "1963854339" @default.
- W1963854339 workType "article" @default.