Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963866029> ?p ?o ?g. }
- W1963866029 endingPage "560" @default.
- W1963866029 startingPage "549" @default.
- W1963866029 abstract "The DNA eicosamer 5′-TCCATGACGTTCCTGATGCT-3′ is known to stimulate the innate immune system of vertebrae. The immunostimulatory activity is based on the activation of Toll-like receptor 9 (TLR9). While it is known that the CG dinucleotide of the eicosamer has to be unmethylated, the structural basis of the recognition of the DNA through the receptor remains unclear. Oligodeoxynucleotides containing the sequence of the eicosamer, or a portion thereof, ranging in length from hexamer to pentaeicosamer were studied by 1H NMR spectroscopy. Based on two-dimensional NMR spectra, a number of resonances could be unambiguously assigned. For all oligonucleotides, structural transitions were detected upon heating, as monitored by the line width and chemical shift of low-field resonances. This includes the TC dinucleotide of the 5′-terminal portion, which does not have any clear base-pairing partners. The melting transitions, together with the NOESY cross-peaks, demonstrate that structure formation occurs well beyond the core hexamer 5′-GACGTT-3′, a fact that may be important for understanding the molecular recognition by the Toll-like receptors of the innate immune system." @default.
- W1963866029 created "2016-06-24" @default.
- W1963866029 creator A5005034645 @default.
- W1963866029 creator A5017638344 @default.
- W1963866029 creator A5018746048 @default.
- W1963866029 creator A5020055533 @default.
- W1963866029 creator A5038034454 @default.
- W1963866029 creator A5039920258 @default.
- W1963866029 creator A5068349575 @default.
- W1963866029 date "2007-04-16" @default.
- W1963866029 modified "2023-10-16" @default.
- W1963866029 title "Immunostimulatory CpG Oligonucleotides Form Defined Three-Dimensional Structures: Results from an NMR Study" @default.
- W1963866029 cites W1483628043 @default.
- W1963866029 cites W1514540900 @default.
- W1963866029 cites W1524792851 @default.
- W1963866029 cites W1917892434 @default.
- W1963866029 cites W1964196894 @default.
- W1963866029 cites W1965573662 @default.
- W1963866029 cites W1970291282 @default.
- W1963866029 cites W1971966571 @default.
- W1963866029 cites W1973590054 @default.
- W1963866029 cites W1975325714 @default.
- W1963866029 cites W1975992370 @default.
- W1963866029 cites W1979956993 @default.
- W1963866029 cites W1987209992 @default.
- W1963866029 cites W1987717753 @default.
- W1963866029 cites W1987867113 @default.
- W1963866029 cites W1988194681 @default.
- W1963866029 cites W1989984780 @default.
- W1963866029 cites W1992999021 @default.
- W1963866029 cites W1993006141 @default.
- W1963866029 cites W1997524551 @default.
- W1963866029 cites W1999587028 @default.
- W1963866029 cites W2003802570 @default.
- W1963866029 cites W2004342444 @default.
- W1963866029 cites W2004726009 @default.
- W1963866029 cites W2005493974 @default.
- W1963866029 cites W2010222913 @default.
- W1963866029 cites W2010473215 @default.
- W1963866029 cites W2015492400 @default.
- W1963866029 cites W2016057259 @default.
- W1963866029 cites W2023309048 @default.
- W1963866029 cites W2023955378 @default.
- W1963866029 cites W2025980739 @default.
- W1963866029 cites W2029667189 @default.
- W1963866029 cites W2029827106 @default.
- W1963866029 cites W2030506606 @default.
- W1963866029 cites W2030819098 @default.
- W1963866029 cites W2032651907 @default.
- W1963866029 cites W2033441782 @default.
- W1963866029 cites W2043179270 @default.
- W1963866029 cites W2043584691 @default.
- W1963866029 cites W2045446885 @default.
- W1963866029 cites W2047366876 @default.
- W1963866029 cites W2061576797 @default.
- W1963866029 cites W2062620592 @default.
- W1963866029 cites W2065423690 @default.
- W1963866029 cites W2069456119 @default.
- W1963866029 cites W2070364388 @default.
- W1963866029 cites W2072933083 @default.
- W1963866029 cites W2074851687 @default.
- W1963866029 cites W2075789186 @default.
- W1963866029 cites W2079183583 @default.
- W1963866029 cites W2080648180 @default.
- W1963866029 cites W2082013812 @default.
- W1963866029 cites W2083829960 @default.
- W1963866029 cites W2089355762 @default.
- W1963866029 cites W2092975717 @default.
- W1963866029 cites W2101760818 @default.
- W1963866029 cites W2107182434 @default.
- W1963866029 cites W2109639632 @default.
- W1963866029 cites W2111819461 @default.
- W1963866029 cites W2118816351 @default.
- W1963866029 cites W2148704093 @default.
- W1963866029 cites W2154143591 @default.
- W1963866029 cites W2160775559 @default.
- W1963866029 cites W2161253720 @default.
- W1963866029 cites W2161577497 @default.
- W1963866029 cites W2164876360 @default.
- W1963866029 cites W2170301089 @default.
- W1963866029 cites W2172060739 @default.
- W1963866029 cites W280694366 @default.
- W1963866029 cites W4249935589 @default.
- W1963866029 doi "https://doi.org/10.1002/cmdc.200600262" @default.
- W1963866029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17366653" @default.
- W1963866029 hasPublicationYear "2007" @default.
- W1963866029 type Work @default.
- W1963866029 sameAs 1963866029 @default.
- W1963866029 citedByCount "7" @default.
- W1963866029 countsByYear W19638660292013 @default.
- W1963866029 countsByYear W19638660292019 @default.
- W1963866029 crossrefType "journal-article" @default.
- W1963866029 hasAuthorship W1963866029A5005034645 @default.
- W1963866029 hasAuthorship W1963866029A5017638344 @default.
- W1963866029 hasAuthorship W1963866029A5018746048 @default.
- W1963866029 hasAuthorship W1963866029A5020055533 @default.
- W1963866029 hasAuthorship W1963866029A5038034454 @default.
- W1963866029 hasAuthorship W1963866029A5039920258 @default.