FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963868571> ?p ?o ?g. }

• W1963868571 endingPage "939" @default.
• W1963868571 startingPage "935" @default.
• W1963868571 abstract "Treatment with transforming growth factor-beta(1) (TGF-beta(1)) has been shown to be effective in accelerating skin wound healing. Another approach to gain the beneficial effects of TGF-beta(1) on wound healing could be the activation of tissue stores of latent TGF-beta(1) with agents such as vitamin A. The aims of this study were to determine whether 1) vitamin A is effective in enhancing intestinal wound healing in vitro and 2) activation of TGF-beta(1) is increased during wound healing with vitamin A treatment. We used the intraluminal chemical induction model of necrotizing enterocolitis (NEC), which was adapted to the 1-wk-old piglet. Injured (NEC) and noninjured full-thickness ileum explants harvested from the piglets were cultured for 24 and 48 h in serum-free medium supplemented with all-trans retinol (ATR; 0, 2, 5, and 10 microM). All concentrations of ATR improved recovery of normal ileal wall cytoarchitecture of NEC explants, with maximal recovery observed with 2 microM ATR after 24 h of culture. Further recovery after 48 h was observed with 5 and 10 microM ATR but did not achieve the degree of healing observed with 2 microM ATR. There were no observable adverse effects of ATR on noninjured ileal explant morphology. Active TGF-beta(1) was identified only in the NEC explants incubated with ATR. The results of this study demonstrate that administration of vitamin A accelerates recovery of normal intestinal wall cytoarchitecture of injured ileum in vitro, without adversely affecting noninjured ileum. The increased activation of latent TGF-beta(1) may, in part, be responsible for the accelerated healing of injured ileum observed with vitamin A administration." @default.
• W1963868571 created "2016-06-24" @default.
• W1963868571 creator A5006028288 @default.
• W1963868571 creator A5068299245 @default.
• W1963868571 date "2004-06-01" @default.
• W1963868571 modified "2023-09-27" @default.
• W1963868571 title "Vitamin A Activation of Transforming Growth Factor-β1 Enhances Porcine Ileum Wound Healing In Vitro" @default.
• W1963868571 cites W1510513224 @default.
• W1963868571 cites W1833914727 @default.
• W1963868571 cites W1966170741 @default.
• W1963868571 cites W1967265019 @default.
• W1963868571 cites W1969131421 @default.
• W1963868571 cites W1975160542 @default.
• W1963868571 cites W1976641850 @default.
• W1963868571 cites W1979722576 @default.
• W1963868571 cites W1983819140 @default.
• W1963868571 cites W1988141478 @default.
• W1963868571 cites W2001937481 @default.
• W1963868571 cites W2007768242 @default.
• W1963868571 cites W2018376390 @default.
• W1963868571 cites W2059501992 @default.
• W1963868571 cites W2079649298 @default.
• W1963868571 cites W2079805620 @default.
• W1963868571 cites W2117233968 @default.
• W1963868571 cites W2137191227 @default.
• W1963868571 cites W2142948151 @default.
• W1963868571 cites W2168240567 @default.
• W1963868571 cites W2321143959 @default.
• W1963868571 cites W2401079225 @default.
• W1963868571 cites W4233112362 @default.
• W1963868571 doi "https://doi.org/10.1203/01.pdr.0000127023.22960.85" @default.
• W1963868571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15155862" @default.
• W1963868571 hasPublicationYear "2004" @default.
• W1963868571 type Work @default.
• W1963868571 sameAs 1963868571 @default.
• W1963868571 citedByCount "17" @default.
• W1963868571 countsByYear W19638685712013 @default.
• W1963868571 countsByYear W19638685712014 @default.
• W1963868571 countsByYear W19638685712015 @default.
• W1963868571 countsByYear W19638685712017 @default.
• W1963868571 countsByYear W19638685712018 @default.
• W1963868571 countsByYear W19638685712019 @default.
• W1963868571 countsByYear W19638685712021 @default.
• W1963868571 countsByYear W19638685712022 @default.
• W1963868571 crossrefType "journal-article" @default.
• W1963868571 hasAuthorship W1963868571A5006028288 @default.
• W1963868571 hasAuthorship W1963868571A5068299245 @default.
• W1963868571 hasBestOaLocation W19638685711 @default.
• W1963868571 hasConcept C105702510 @default.
• W1963868571 hasConcept C118131993 @default.
• W1963868571 hasConcept C126322002 @default.
• W1963868571 hasConcept C134018914 @default.
• W1963868571 hasConcept C142724271 @default.
• W1963868571 hasConcept C157890192 @default.
• W1963868571 hasConcept C163895629 @default.
• W1963868571 hasConcept C16685009 @default.
• W1963868571 hasConcept C202751555 @default.
• W1963868571 hasConcept C203014093 @default.
• W1963868571 hasConcept C2776940978 @default.
• W1963868571 hasConcept C2777226302 @default.
• W1963868571 hasConcept C2780269544 @default.
• W1963868571 hasConcept C55493867 @default.
• W1963868571 hasConcept C71924100 @default.
• W1963868571 hasConcept C86803240 @default.
• W1963868571 hasConceptScore W1963868571C105702510 @default.
• W1963868571 hasConceptScore W1963868571C118131993 @default.
• W1963868571 hasConceptScore W1963868571C126322002 @default.
• W1963868571 hasConceptScore W1963868571C134018914 @default.
• W1963868571 hasConceptScore W1963868571C142724271 @default.
• W1963868571 hasConceptScore W1963868571C157890192 @default.
• W1963868571 hasConceptScore W1963868571C163895629 @default.
• W1963868571 hasConceptScore W1963868571C16685009 @default.
• W1963868571 hasConceptScore W1963868571C202751555 @default.
• W1963868571 hasConceptScore W1963868571C203014093 @default.
• W1963868571 hasConceptScore W1963868571C2776940978 @default.
• W1963868571 hasConceptScore W1963868571C2777226302 @default.
• W1963868571 hasConceptScore W1963868571C2780269544 @default.
• W1963868571 hasConceptScore W1963868571C55493867 @default.
• W1963868571 hasConceptScore W1963868571C71924100 @default.
• W1963868571 hasConceptScore W1963868571C86803240 @default.
• W1963868571 hasIssue "6" @default.
• W1963868571 hasLocation W19638685711 @default.
• W1963868571 hasLocation W19638685712 @default.
• W1963868571 hasOpenAccess W1963868571 @default.
• W1963868571 hasPrimaryLocation W19638685711 @default.
• W1963868571 hasRelatedWork W1966504330 @default.
• W1963868571 hasRelatedWork W1967386430 @default.
• W1963868571 hasRelatedWork W1979139803 @default.
• W1963868571 hasRelatedWork W2030889776 @default.
• W1963868571 hasRelatedWork W2037631372 @default.
• W1963868571 hasRelatedWork W2040058909 @default.
• W1963868571 hasRelatedWork W2040672875 @default.
• W1963868571 hasRelatedWork W2067357351 @default.
• W1963868571 hasRelatedWork W2132898409 @default.
• W1963868571 hasRelatedWork W2748952813 @default.
• W1963868571 hasVolume "55" @default.
• W1963868571 isParatext "false" @default.
• W1963868571 isRetracted "false" @default.

• next