Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963874911> ?p ?o ?g. }
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- W1963874911 abstract "► IL-15 has been implicated in the development and immunobiology of both NK and CD8 T cells. ► Virally induced IL-15 influences the migration and effector function of NK and CD8 T cells. ► IL-15 has great potential for modulating anti-viral immune responses and vaccine development. An effective immune response to an invading viral pathogen requires the combined actions of both innate and adaptive immune cells. For example, NK cells and cytotoxic CD8 T cells are capable of the direct engagement of infected cells and the mediation of antiviral responses. Both NK and CD8 T cells depend on common gamma chain (γc) cytokine signals for their development and homeostasis. The γc cytokine IL-15 is very well characterized for its role in promoting the development and homeostasis of NK cells and CD8 T cells, but emerging literature suggests that IL-15 mediates the anti-viral responses of these cell populations during an active immune response. Both NK cells and CD8 T cells must become activated, migrate to sites of infection, survive at those sites, and expand in order to maximally exert effector functions, and IL-15 can modulate each of these processes. This review focuses on the functions of IL-15 in the regulation of multiple aspects of NK and CD8 T cell biology, investigates the mechanisms by which IL-15 may exert such diverse functions, and discusses how these different facets of IL-15 biology may be therapeutically exploited to combat viral diseases." @default.
- W1963874911 created "2016-06-24" @default.
- W1963874911 creator A5008358695 @default.
- W1963874911 creator A5088475100 @default.
- W1963874911 date "2012-09-01" @default.
- W1963874911 modified "2023-10-14" @default.
- W1963874911 title "Functions of IL-15 in anti-viral immunity: Multiplicity and variety" @default.
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