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- W1963875008 abstract "Spinal cord injury triggers a complex set of events that lead to tissue healing without the restoration of normal function due to the poor regenerative capacity of the spinal cord. Nevertheless, current knowledge about the intrinsic regenerative ability of central nervous system axons, when in a supportive environment, has made the prospect of treating spinal cord injury a reality. Among the range of strategies under investigation, cell-based therapies offer the most promising results, due to the multifactorial roles that these cells can fulfil. However, the best cell source is still a matter of debate, as are clinical issues that include the optimal cell dose as well as the timing and route of administration. In this context, the role of biomaterials is gaining importance. These can not only act as vehicles for the administered cells but also, in the case of chronic lesions, can be used to fill the permanent cyst, thus creating a more favourable and conducive environment for axonal regeneration in addition to serving as local delivery systems of therapeutic agents to improve the regenerative milieu. Some of the candidate molecules for the future are discussed in view of the knowledge derived from studying the mechanisms that facilitate the intrinsic regenerative capacity of central nervous system neurons. The future challenge for the multidisciplinary teams working in the field is to translate the knowledge acquired in basic research into effective combinatorial therapies to be applied in the clinic." @default.
- W1963875008 created "2016-06-24" @default.
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- W1963875008 date "2012-10-29" @default.
- W1963875008 modified "2023-10-16" @default.
- W1963875008 title "Regenerative medicine for the treatment of spinal cord injury: more than just promises?" @default.
- W1963875008 cites W1506438655 @default.
- W1963875008 cites W1539440045 @default.
- W1963875008 cites W1561819219 @default.
- W1963875008 cites W1634672871 @default.
- W1963875008 cites W1932898357 @default.
- W1963875008 cites W1961182906 @default.
- W1963875008 cites W1964146045 @default.
- W1963875008 cites W1967599454 @default.
- W1963875008 cites W1968840425 @default.
- W1963875008 cites W1970470068 @default.
- W1963875008 cites W1970608630 @default.
- W1963875008 cites W1974747930 @default.
- W1963875008 cites W1974940638 @default.
- W1963875008 cites W1976935502 @default.
- W1963875008 cites W1978370369 @default.
- W1963875008 cites W1980198056 @default.
- W1963875008 cites W1980977837 @default.
- W1963875008 cites W1981131778 @default.
- W1963875008 cites W1981188246 @default.
- W1963875008 cites W1981287437 @default.
- W1963875008 cites W1981621010 @default.
- W1963875008 cites W1982309486 @default.
- W1963875008 cites W1982690424 @default.
- W1963875008 cites W1982737759 @default.
- W1963875008 cites W1983712592 @default.
- W1963875008 cites W1984382082 @default.
- W1963875008 cites W1987408946 @default.
- W1963875008 cites W1987432705 @default.
- W1963875008 cites W1989228737 @default.
- W1963875008 cites W1990228542 @default.
- W1963875008 cites W1992373160 @default.
- W1963875008 cites W1993726035 @default.
- W1963875008 cites W1997721049 @default.
- W1963875008 cites W1998279367 @default.
- W1963875008 cites W1998384354 @default.
- W1963875008 cites W1999457633 @default.
- W1963875008 cites W1999941576 @default.
- W1963875008 cites W2000401553 @default.
- W1963875008 cites W2000891340 @default.
- W1963875008 cites W2003022011 @default.
- W1963875008 cites W2004800810 @default.
- W1963875008 cites W2005327608 @default.
- W1963875008 cites W2006132770 @default.
- W1963875008 cites W2006408401 @default.
- W1963875008 cites W2006858545 @default.
- W1963875008 cites W2006862730 @default.
- W1963875008 cites W2007481890 @default.
- W1963875008 cites W2009191172 @default.
- W1963875008 cites W2010771423 @default.
- W1963875008 cites W2010975205 @default.
- W1963875008 cites W2011597829 @default.
- W1963875008 cites W2012928251 @default.
- W1963875008 cites W2013035816 @default.
- W1963875008 cites W2015952490 @default.
- W1963875008 cites W2016090513 @default.
- W1963875008 cites W2016616421 @default.
- W1963875008 cites W2017343522 @default.
- W1963875008 cites W2019662991 @default.
- W1963875008 cites W2020180197 @default.
- W1963875008 cites W2020340848 @default.
- W1963875008 cites W2020475323 @default.
- W1963875008 cites W2021696469 @default.
- W1963875008 cites W2023814366 @default.
- W1963875008 cites W2024405375 @default.
- W1963875008 cites W2025171322 @default.
- W1963875008 cites W2026225922 @default.
- W1963875008 cites W2026757435 @default.
- W1963875008 cites W2028735479 @default.
- W1963875008 cites W2029768920 @default.
- W1963875008 cites W2030498840 @default.
- W1963875008 cites W2030927825 @default.
- W1963875008 cites W2031023695 @default.
- W1963875008 cites W2031155651 @default.
- W1963875008 cites W2031874070 @default.
- W1963875008 cites W2032696345 @default.
- W1963875008 cites W2032989272 @default.
- W1963875008 cites W2033503301 @default.
- W1963875008 cites W2034093757 @default.
- W1963875008 cites W2034500742 @default.
- W1963875008 cites W2037781386 @default.
- W1963875008 cites W2040281629 @default.
- W1963875008 cites W2041229780 @default.
- W1963875008 cites W2041773411 @default.
- W1963875008 cites W2042507758 @default.
- W1963875008 cites W2042862506 @default.
- W1963875008 cites W2043016721 @default.