FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963877462> ?p ?o ?g. }

• W1963877462 endingPage "160" @default.
• W1963877462 startingPage "155" @default.
• W1963877462 abstract "Genetic engineering of donor animals in xenotransplantation research has been directed largely toward obtaining expression of various immunoregulatory molecules on vascular endothelium, the initial target of recipient antibody and complement. However, specific high-level expression of transgenes throughout the vascular tree in adult animals has proved difficult to achieve, perhaps because of the inherent heterogeneity of endothelium. Using the promoter of the gene for intercellular adhesion molecule 2 (ICAM-2), which is constitutively expressed on all vascular endothelium, we have developed a system for endothelial cell gene targeting in vivo. A 334-basepair fragment from the 5′ flanking region of the human ICAM-2 gene was used to drive the expression of human CD59 in transgenic mice. Strong and uniform expression of CD59 was observed on the endothelial cells of all blood vessels in the heart, kidney, lung, liver, and pancreas in the three lines of mice examined. Little or no expression was seen in other cell types, with the exception of neutrophils and monocytes. These results suggest that this small promoter region contains most of the signals necessary to endow it with endothelial cell specificity, making it a potentially valuable tool in areas ranging from xenotransplantation to gene therapy." @default.
• W1963877462 created "2016-06-24" @default.
• W1963877462 creator A5019295669 @default.
• W1963877462 creator A5033376741 @default.
• W1963877462 creator A5039238202 @default.
• W1963877462 creator A5050323998 @default.
• W1963877462 creator A5067910050 @default.
• W1963877462 creator A5070193700 @default.
• W1963877462 date "1996-07-01" @default.
• W1963877462 modified "2023-10-12" @default.
• W1963877462 title "TARGETING GENE EXPRESSION TO ENDOTHELIAL CELLS IN TRANSGENIC MICE USING THE HUMAN INTERCELLULAR ADHESION MOLECULE 2 PROMOTER1" @default.
• W1963877462 cites W1540687523 @default.
• W1963877462 cites W1809398380 @default.
• W1963877462 cites W1825606417 @default.
• W1963877462 cites W1837120183 @default.
• W1963877462 cites W1838110840 @default.
• W1963877462 cites W1860470769 @default.
• W1963877462 cites W1981569039 @default.
• W1963877462 cites W2020971843 @default.
• W1963877462 cites W2046644549 @default.
• W1963877462 cites W2053134592 @default.
• W1963877462 cites W2059171126 @default.
• W1963877462 cites W2065519715 @default.
• W1963877462 cites W2066010552 @default.
• W1963877462 cites W2079304688 @default.
• W1963877462 cites W2094434788 @default.
• W1963877462 cites W2103493503 @default.
• W1963877462 cites W2129346720 @default.
• W1963877462 cites W2142524165 @default.
• W1963877462 cites W2147144400 @default.
• W1963877462 cites W2152962086 @default.
• W1963877462 cites W4233069367 @default.
• W1963877462 doi "https://doi.org/10.1097/00007890-199607270-00002" @default.
• W1963877462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8755809" @default.
• W1963877462 hasPublicationYear "1996" @default.
• W1963877462 type Work @default.
• W1963877462 sameAs 1963877462 @default.
• W1963877462 citedByCount "70" @default.
• W1963877462 countsByYear W19638774622013 @default.
• W1963877462 countsByYear W19638774622014 @default.
• W1963877462 countsByYear W19638774622016 @default.
• W1963877462 countsByYear W19638774622017 @default.
• W1963877462 countsByYear W19638774622018 @default.
• W1963877462 crossrefType "journal-article" @default.
• W1963877462 hasAuthorship W1963877462A5019295669 @default.
• W1963877462 hasAuthorship W1963877462A5033376741 @default.
• W1963877462 hasAuthorship W1963877462A5039238202 @default.
• W1963877462 hasAuthorship W1963877462A5050323998 @default.
• W1963877462 hasAuthorship W1963877462A5067910050 @default.
• W1963877462 hasAuthorship W1963877462A5070193700 @default.
• W1963877462 hasBestOaLocation W19638774621 @default.
• W1963877462 hasConcept C102230213 @default.
• W1963877462 hasConcept C104317684 @default.
• W1963877462 hasConcept C111829913 @default.
• W1963877462 hasConcept C123012128 @default.
• W1963877462 hasConcept C141035611 @default.
• W1963877462 hasConcept C141071460 @default.
• W1963877462 hasConcept C150194340 @default.
• W1963877462 hasConcept C153911025 @default.
• W1963877462 hasConcept C16224149 @default.
• W1963877462 hasConcept C202751555 @default.
• W1963877462 hasConcept C203014093 @default.
• W1963877462 hasConcept C2776992346 @default.
• W1963877462 hasConcept C2778442404 @default.
• W1963877462 hasConcept C2911091166 @default.
• W1963877462 hasConcept C54355233 @default.
• W1963877462 hasConcept C71924100 @default.
• W1963877462 hasConcept C86803240 @default.
• W1963877462 hasConcept C95444343 @default.
• W1963877462 hasConceptScore W1963877462C102230213 @default.
• W1963877462 hasConceptScore W1963877462C104317684 @default.
• W1963877462 hasConceptScore W1963877462C111829913 @default.
• W1963877462 hasConceptScore W1963877462C123012128 @default.
• W1963877462 hasConceptScore W1963877462C141035611 @default.
• W1963877462 hasConceptScore W1963877462C141071460 @default.
• W1963877462 hasConceptScore W1963877462C150194340 @default.
• W1963877462 hasConceptScore W1963877462C153911025 @default.
• W1963877462 hasConceptScore W1963877462C16224149 @default.
• W1963877462 hasConceptScore W1963877462C202751555 @default.
• W1963877462 hasConceptScore W1963877462C203014093 @default.
• W1963877462 hasConceptScore W1963877462C2776992346 @default.
• W1963877462 hasConceptScore W1963877462C2778442404 @default.
• W1963877462 hasConceptScore W1963877462C2911091166 @default.
• W1963877462 hasConceptScore W1963877462C54355233 @default.
• W1963877462 hasConceptScore W1963877462C71924100 @default.
• W1963877462 hasConceptScore W1963877462C86803240 @default.
• W1963877462 hasConceptScore W1963877462C95444343 @default.
• W1963877462 hasIssue "2" @default.
• W1963877462 hasLocation W19638774621 @default.
• W1963877462 hasLocation W19638774622 @default.
• W1963877462 hasLocation W19638774623 @default.
• W1963877462 hasOpenAccess W1963877462 @default.
• W1963877462 hasPrimaryLocation W19638774621 @default.
• W1963877462 hasRelatedWork W1489857015 @default.
• W1963877462 hasRelatedWork W2001833660 @default.
• W1963877462 hasRelatedWork W2010141405 @default.
• W1963877462 hasRelatedWork W2017330739 @default.
• W1963877462 hasRelatedWork W2030084515 @default.

• next