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- W1963886368 abstract "Total catecholamine excretion (consisting essentially of adrenaline plus noradrenaline) and noradrenaline excretion which were determined by a routine fluorometric procedure and a fluorometric differential technic, respectively, were found to be increased in about 10 per cent of patients with essential hypertension. This observation was considered to be without statistical significance. No correlation was observed between the excretion of total catecholamines and the mean arterial blood pressure in nontreated hypertensive patients. Patients receiving treatment with thiazides or guanethidine alone showed lower figures of total catecholamine excretion compared with nontreatecd hypertensive patients. Reserpine alone or combined with thiazides and other drugs produced no statistically significant decrease of excretion. The day-night excretion rate of catecholamines showed a sharp, highly significant decrease of adrenaline during night hours. Noradrenaline also showed a decrease during night hours which was, however, without statistical significance. Dopamine excretion was almost identical during night and day periods. No difference was found between normal controls and hypertensive patients regarding the day-night rate excretion pattern of catecholamines. The mean figure of dopamine excretion was sharply reduced (p < 0.001) in the hypertensive patients as compared with normal subjects. Possible implications of these findings in regard to catecholamine metabolism in essential hypertension are discussed." @default.
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- W1963886368 date "1964-04-01" @default.
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- W1963886368 title "Adrenaline, Noradrenaline and Dopamine excretion in patients with essential hypertension" @default.
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- W1963886368 doi "https://doi.org/10.1016/0002-9149(64)90155-9" @default.
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