FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963889055> ?p ?o ?g. }

• W1963889055 endingPage "420" @default.
• W1963889055 startingPage "415" @default.
• W1963889055 abstract "More than 10 clinical trials of Aβ immunotherapy are currently underway in patients with Alzheimer’s disease (AD). The aim is to identify safe approaches for the efficacious antibody-mediated removal of brain β-amyloid or its neurotoxic oligomeric precursors consisting of aggregated amyloid β-peptide (Aβ). Initial experimental and neuro-pathological evidence for clearance of brain β-amyloid in response to Aβ immunotherapy is associated with structural and functional rescue of neurons, as well as initial signs of clinical stabilization and reduced rates of dementia progression. For the next steps in the future improvement of Aβ immunotherapy, major challenges in pharmacokinetics, safety, and tolerability need to be addressed. These include the low penetrations rates of IgG molecules through the blood-brain barrier, possible reductions in brain volume, the possibility of autoimmune disease related to unwanted cross-reactivity with endogenous antigens on physiological structures, micro-hemorrhages related to cross-reaction with pre-existing vascular amyloid pathology, possible relocalization of Aβ from β-amyloid plaques to brain blood vessels resulting in increased amyloid angiopathy, and the lacking activity of Aβ antibodies on pre-existing neurofibrillary tangle pathology, as well as the lacking molecular identification of the forms of Aβ to be therapeutic ally targeted. The solutions to these problems will be guided by the fine lines between tolerance and immunity against physiological and pathological structures, respectively, as well as by the understanding of the pathogenic transition of soluble Aβ into toxic oligomeric aggregation intermediates in the dynamic equilibrium of β-amyloid fibril assembly. Provided that the ongoing and planned clinical trials address these issues in a timely manner, there is a good chance for Aβ immunotherapy to be one of the first disease-modifying therapies of Alzheimer’s disease to be introduced into clinical practice." @default.
• W1963889055 created "2016-06-24" @default.
• W1963889055 creator A5048324375 @default.
• W1963889055 creator A5086913074 @default.
• W1963889055 date "2008-07-01" @default.
• W1963889055 modified "2023-10-16" @default.
• W1963889055 title "Targeting β-amyloid pathology in Alzheimer’s disease with Aβ immunotherapy" @default.
• W1963889055 cites W1494074009 @default.
• W1963889055 cites W1528113046 @default.
• W1963889055 cites W1546526125 @default.
• W1963889055 cites W1567490604 @default.
• W1963889055 cites W1621971853 @default.
• W1963889055 cites W1667130205 @default.
• W1963889055 cites W1693283493 @default.
• W1963889055 cites W1823419340 @default.
• W1963889055 cites W1965275873 @default.
• W1963889055 cites W1967549235 @default.
• W1963889055 cites W1967777458 @default.
• W1963889055 cites W1974894459 @default.
• W1963889055 cites W1979415323 @default.
• W1963889055 cites W1981458288 @default.
• W1963889055 cites W1987373495 @default.
• W1963889055 cites W1991989649 @default.
• W1963889055 cites W1991993391 @default.
• W1963889055 cites W1995208082 @default.
• W1963889055 cites W1996788036 @default.
• W1963889055 cites W1996995902 @default.
• W1963889055 cites W2000917982 @default.
• W1963889055 cites W2001704669 @default.
• W1963889055 cites W2002520289 @default.
• W1963889055 cites W2006696380 @default.
• W1963889055 cites W2010865396 @default.
• W1963889055 cites W2020497815 @default.
• W1963889055 cites W2024262813 @default.
• W1963889055 cites W2025152196 @default.
• W1963889055 cites W2025561374 @default.
• W1963889055 cites W2028937444 @default.
• W1963889055 cites W2035470211 @default.
• W1963889055 cites W2037819517 @default.
• W1963889055 cites W2055388053 @default.
• W1963889055 cites W2059861908 @default.
• W1963889055 cites W2075481535 @default.
• W1963889055 cites W2078530054 @default.
• W1963889055 cites W2093629582 @default.
• W1963889055 cites W2100298346 @default.
• W1963889055 cites W2105704879 @default.
• W1963889055 cites W2105758687 @default.
• W1963889055 cites W2109031511 @default.
• W1963889055 cites W2110888808 @default.
• W1963889055 cites W2112216133 @default.
• W1963889055 cites W2121448546 @default.
• W1963889055 cites W2123927794 @default.
• W1963889055 cites W2132234293 @default.
• W1963889055 cites W2135263069 @default.
• W1963889055 cites W2139458712 @default.
• W1963889055 cites W2150999725 @default.
• W1963889055 cites W2155473285 @default.
• W1963889055 cites W2157064933 @default.
• W1963889055 cites W2160676126 @default.
• W1963889055 cites W2164535032 @default.
• W1963889055 cites W2167720733 @default.
• W1963889055 cites W2169831064 @default.
• W1963889055 cites W2170241219 @default.
• W1963889055 cites W338668673 @default.
• W1963889055 cites W4296588353 @default.
• W1963889055 cites W4313105713 @default.
• W1963889055 doi "https://doi.org/10.1016/j.nurt.2008.05.013" @default.
• W1963889055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5084243" @default.
• W1963889055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18625453" @default.
• W1963889055 hasPublicationYear "2008" @default.
• W1963889055 type Work @default.
• W1963889055 sameAs 1963889055 @default.
• W1963889055 citedByCount "60" @default.
• W1963889055 countsByYear W19638890552012 @default.
• W1963889055 countsByYear W19638890552013 @default.
• W1963889055 countsByYear W19638890552014 @default.
• W1963889055 countsByYear W19638890552015 @default.
• W1963889055 countsByYear W19638890552016 @default.
• W1963889055 countsByYear W19638890552017 @default.
• W1963889055 countsByYear W19638890552018 @default.
• W1963889055 countsByYear W19638890552019 @default.
• W1963889055 countsByYear W19638890552020 @default.
• W1963889055 countsByYear W19638890552021 @default.
• W1963889055 crossrefType "journal-article" @default.
• W1963889055 hasAuthorship W1963889055A5048324375 @default.
• W1963889055 hasAuthorship W1963889055A5086913074 @default.
• W1963889055 hasBestOaLocation W19638890551 @default.
• W1963889055 hasConcept C118552586 @default.
• W1963889055 hasConcept C142724271 @default.
• W1963889055 hasConcept C16568411 @default.
• W1963889055 hasConcept C169760540 @default.
• W1963889055 hasConcept C203014093 @default.
• W1963889055 hasConcept C204787440 @default.
• W1963889055 hasConcept C2777633098 @default.
• W1963889055 hasConcept C2777701055 @default.
• W1963889055 hasConcept C2777790613 @default.
• W1963889055 hasConcept C2778375690 @default.
• W1963889055 hasConcept C2779134260 @default.

• next