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- W1963889969 abstract "Saccharomyces cerevisiae Rad9 is required for an effective DNA damage response throughout the cell cycle. Assembly of Rad9 on chromatin after DNA damage is promoted by histone modifications that create docking sites for Rad9 recruitment, allowing checkpoint activation. Rad53 phosphorylation is also dependent upon BRCT-directed Rad9 oligomerization; however, the crosstalk between these molecular determinants and their functional significance are poorly understood. Here we report that, in the G1 and M phases of the cell cycle, both constitutive and DNA damage-dependent Rad9 chromatin association require its BRCT domains. In G1 cells, GST or FKBP dimerization motifs can substitute to the BRCT domains for Rad9 chromatin binding and checkpoint function. Conversely, forced Rad9 dimerization in M phase fails to promote its recruitment onto DNA, although it supports Rad9 checkpoint function. In fact, a parallel pathway, independent on histone modifications and governed by CDK1 activity, allows checkpoint activation in the absence of Rad9 chromatin binding. CDK1-dependent phosphorylation of Rad9 on Ser11 leads to specific interaction with Dpb11, allowing Rad53 activation and bypassing the requirement for the histone branch." @default.
- W1963889969 created "2016-06-24" @default.
- W1963889969 creator A5004890439 @default.
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- W1963889969 date "2010-08-05" @default.
- W1963889969 modified "2023-10-16" @default.
- W1963889969 title "Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity" @default.
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- W1963889969 doi "https://doi.org/10.1371/journal.pgen.1001047" @default.
- W1963889969 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2916856" @default.
- W1963889969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20700441" @default.
- W1963889969 hasPublicationYear "2010" @default.
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