FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963890121> ?p ?o ?g. }

• W1963890121 endingPage "102" @default.
• W1963890121 startingPage "92" @default.
• W1963890121 abstract "After fertilization in the mouse, the zygotic genome is activated in two-cell embryos by the spontaneous expression, among other genes, of the major inducible heat shock gene, hsp68, in the absence of heat-inducibility of heat shock genes. To obtain information on this phenomenon, we have probed one- and two-cell embryo's ability to express microinjected reporter DNA constructs, containing the Escherichia coli lacZ gene driven by promoters from early SV40 genes, the human ß-actin gene, and the normal or HSE-deleted mouse hsp68 gene. Activity of these promoters was also tested in mouse granulosa cells and dictyate oocytes, as a function of circular/linear construct configuration and occurrence of heat shock. The hsp68 promoter was heat-inducible in both granulosa cells and oocytes. Its heat activation required the presence of HSEs and, in the oocytes, of construct linear configuration. In the embryos however, this promoter was expressed in dependently of the presence of HSEs and of construct configuration, and its activity was not affected by heat shock. When constructs with early SV40 and ß-actin promoters were injected into one-cell embryos, they appeared to be inactivated with the first embryonic cleavage, in agreement with previous observations [Wiekowski et ai., 1992]. By contrast, both normal and HSE-deleted hsp68 promoters maintained their activity through the first cleavage, providing the first evidence of a gene escaping such transcriptional repression. Present results confirm previous findings on hsp68 expression during early mouse development, and suggest that this activation is mediated by a factor(s) other than HSF. © 1993Wiley-Liss, Inc." @default.
• W1963890121 created "2016-06-24" @default.
• W1963890121 creator A5066395655 @default.
• W1963890121 creator A5071079462 @default.
• W1963890121 date "1993-01-01" @default.
• W1963890121 modified "2023-09-23" @default.
• W1963890121 title "Activity of a microinjected inducible murine hsp68 gene promoter depends on plasmid configuration and the presence of heat shock elements in mouse dictyate oocytes but not in two-cell embryos" @default.
• W1963890121 cites W1205396264 @default.
• W1963890121 cites W1433025566 @default.
• W1963890121 cites W1589129578 @default.
• W1963890121 cites W1755621802 @default.
• W1963890121 cites W1756042051 @default.
• W1963890121 cites W1836619428 @default.
• W1963890121 cites W1837845339 @default.
• W1963890121 cites W1961486015 @default.
• W1963890121 cites W1966171919 @default.
• W1963890121 cites W1975210113 @default.
• W1963890121 cites W1980677322 @default.
• W1963890121 cites W1985100447 @default.
• W1963890121 cites W1986291674 @default.
• W1963890121 cites W1990829842 @default.
• W1963890121 cites W1994202862 @default.
• W1963890121 cites W2002858868 @default.
• W1963890121 cites W2005131012 @default.
• W1963890121 cites W2013551831 @default.
• W1963890121 cites W2013683245 @default.
• W1963890121 cites W2014345292 @default.
• W1963890121 cites W2016500677 @default.
• W1963890121 cites W2018294925 @default.
• W1963890121 cites W2027179286 @default.
• W1963890121 cites W2029375782 @default.
• W1963890121 cites W2040235353 @default.
• W1963890121 cites W2042564071 @default.
• W1963890121 cites W2045685769 @default.
• W1963890121 cites W2048680017 @default.
• W1963890121 cites W2051643639 @default.
• W1963890121 cites W2052748168 @default.
• W1963890121 cites W2054454491 @default.
• W1963890121 cites W2056782646 @default.
• W1963890121 cites W2065516296 @default.
• W1963890121 cites W2068779520 @default.
• W1963890121 cites W2068903746 @default.
• W1963890121 cites W2074565496 @default.
• W1963890121 cites W2083768536 @default.
• W1963890121 cites W2084460671 @default.
• W1963890121 cites W2086853483 @default.
• W1963890121 cites W2088210617 @default.
• W1963890121 cites W2095198815 @default.
• W1963890121 cites W2103431676 @default.
• W1963890121 cites W2106384420 @default.
• W1963890121 cites W2111931260 @default.
• W1963890121 cites W2126120030 @default.
• W1963890121 cites W2129381471 @default.
• W1963890121 cites W2136959750 @default.
• W1963890121 cites W2163964409 @default.
• W1963890121 cites W2166275296 @default.
• W1963890121 cites W2244774491 @default.
• W1963890121 cites W4235592770 @default.
• W1963890121 doi "https://doi.org/10.1002/dvg.1020140203" @default.
• W1963890121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8482021" @default.
• W1963890121 hasPublicationYear "1993" @default.
• W1963890121 type Work @default.
• W1963890121 sameAs 1963890121 @default.
• W1963890121 citedByCount "11" @default.
• W1963890121 crossrefType "journal-article" @default.
• W1963890121 hasAuthorship W1963890121A5066395655 @default.
• W1963890121 hasAuthorship W1963890121A5071079462 @default.
• W1963890121 hasConcept C101762097 @default.
• W1963890121 hasConcept C104317684 @default.
• W1963890121 hasConcept C137984847 @default.
• W1963890121 hasConcept C150194340 @default.
• W1963890121 hasConcept C153911025 @default.
• W1963890121 hasConcept C161733203 @default.
• W1963890121 hasConcept C196843134 @default.
• W1963890121 hasConcept C205260736 @default.
• W1963890121 hasConcept C54355233 @default.
• W1963890121 hasConcept C86803240 @default.
• W1963890121 hasConcept C95444343 @default.
• W1963890121 hasConceptScore W1963890121C101762097 @default.
• W1963890121 hasConceptScore W1963890121C104317684 @default.
• W1963890121 hasConceptScore W1963890121C137984847 @default.
• W1963890121 hasConceptScore W1963890121C150194340 @default.
• W1963890121 hasConceptScore W1963890121C153911025 @default.
• W1963890121 hasConceptScore W1963890121C161733203 @default.
• W1963890121 hasConceptScore W1963890121C196843134 @default.
• W1963890121 hasConceptScore W1963890121C205260736 @default.
• W1963890121 hasConceptScore W1963890121C54355233 @default.
• W1963890121 hasConceptScore W1963890121C86803240 @default.
• W1963890121 hasConceptScore W1963890121C95444343 @default.
• W1963890121 hasIssue "2" @default.
• W1963890121 hasLocation W19638901211 @default.
• W1963890121 hasLocation W19638901212 @default.
• W1963890121 hasOpenAccess W1963890121 @default.
• W1963890121 hasPrimaryLocation W19638901211 @default.
• W1963890121 hasRelatedWork W1548521518 @default.
• W1963890121 hasRelatedWork W1641001208 @default.
• W1963890121 hasRelatedWork W1989946857 @default.
• W1963890121 hasRelatedWork W2009966535 @default.

• next