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• W1963896178 abstract "Various inhibitors of arachidonic acid (AA) metabolism were investigated for their effects on the development of cell-mediated immunity (CMI) by murine lymphocytes against allogeneic P815 mastocytoma cells in culture. These effects were measured by measuring cellular proliferation and generation of cytoxicity. Indomethacin, aspirin, octadeca-9, 12-diynoic acid (Ro 3-1314) and d, 1-6-chloro-α-methylcarbazole-2-acetic acid (Ro 20-5720), inhibitors of cyclo-oxygenase, caused augmentation of CMI response development. Nordihydroguaiaretic acid (NDGA), an inhibitor of lipoxygenase, caused 50% inhibition at 30 μM. 5,8,11,14-Eicosatetraynoic acid, an inhibitor of lipoxygenase and cyclo-oxygenase, enhanced CMI at 8 μM, but inhibited these responses by 50% at 60 μM. Imidazole and 1-methylimidazole, inhibitors of thromboxane synthetase, inhibited CMI by 50% at about 3 mM. Tranylcypromine (tranyl), an inhibitor of prostacyclin synthetase, enhanced CMI. Indomethacin, imidazole or tranylcypromine must be added to the lymphocyte cultures within 24 h after antigen in order to have an effect on CMI. The combination of indomethacin and imidazole showed that they are antagonistic in their effects on CMI. The combination of indomethacin and tranyl showed that the stimulatory effects of indomethacin and tranyl are additive. The combination of indomethacin and NDGA showed that the stimulatory effect of indomethacin is prevented by NDGA. Taken together the data suggest that the presence of various inhibitors of AA metabolism affect the regulation of CMI, apparently by changing the relative levels of the metabolites of AA. These findings imply that the products of both the lipoxygenase and the cyclo-oxygenase pathways may play important roles in the modulation of CMI and that these products may have opposing properties in terms of effects on CMI. The dependence of the effects upon the time of inhibitor addition to CMI cultures suggests that the modulation occurs early during the inductive phase of CMI." @default.
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• W1963896178 date "1982-01-01" @default.
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• W1963896178 title "Modulation of the development of cell-mediated immunity: Possible role of the products of the cyclo-oxygenase and the lipoxygenase pathways of arachidonic acid metabolism" @default.
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• W1963896178 doi "https://doi.org/10.1016/0192-0561(82)90049-2" @default.
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