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• W1963899666 abstract "SNARE-mediated membrane fusion is a pivotal event for a wide-variety of biological processes. SNAP-25, a neuron-specific SNARE protein, has been well-characterized and mouse embryos lacking Snap25 are viable. However, the phenotype of mice lacking SNAP-23, the ubiquitously expressed SNAP-25 homolog, remains unknown. To reveal the importance of SNAP-23 function in mouse development, we generated Snap23-null mice by homologous recombination. We were unable to obtain newborn SNAP-23-deficient mice, and analysis of pre-implantation embryos from Snap23(Δ/wt) matings revealed that Snap23-null blastocysts were dying prior to implantation at embryonic day E3.5. Thus these data reveal a critical role for SNAP-23 during embryogenesis." @default.
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• W1963899666 date "2011-03-29" @default.
• W1963899666 modified "2023-09-25" @default.
• W1963899666 title "Deletion of SNAP-23 Results in Pre-Implantation Embryonic Lethality in Mice" @default.
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• W1963899666 doi "https://doi.org/10.1371/journal.pone.0018444" @default.
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