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• W1963907541 abstract "Eight hours after intracerebral injection of a double-labeled 3-ketoceramide4, [1-14C]lignoceroyl 3-keto [1-3H]sphingosine, various brain sphingolipids were isolated. Free ceramide and the ceramide portions of nonhydroxy cerebroside and sphingomyelin were further fractionated into subgroups containing longer-chain or shorter-chain fatty acids. Nonhydroxy ceramide, nonhydroxy cerebroside and sphingomyelin containing longer-chain fatty acids had significant quantities of radioactivity with 3H/14C ratios similar to each other but lower than that of the injected material. The sphingolipids containing shorter-chain fatty acids were also significantly labeled; however, the 3H/14C ratios were much higher than that of the injected material. Hydroxy-ceramide and sulfatides contained very little radioactivity. However, hydroxy-cerebroside contained an amount of radioactivity comparable to that of the longer-chain nonhydroxy cerebroside with a similar 3H/14C ratio. It is proposed that the injected 3-ketoceramide was converted into ceramide, cerebroside, and sphingomyelin and that the fatty acids of these lipids were partly replaced by other fatty acids during the metabolic conversions." @default.
• W1963907541 created "2016-06-24" @default.
• W1963907541 creator A5004827664 @default.
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• W1963907541 date "1978-02-01" @default.
• W1963907541 modified "2023-10-16" @default.
• W1963907541 title "IN VIVO METABOLISM OF 3-KETOCERAMIDE IN RAT BRAIN" @default.
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• W1963907541 doi "https://doi.org/10.1111/j.1471-4159.1978.tb06540.x" @default.
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