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- W1963908314 abstract "OBJECTIVES Gastroesophageal reflux disease (GERD) is an important cause of non-cardiac chest pain (NCCP), and its detection can require ambulatory pH monitoring. The purpose of this study was to determine the advantages of a wireless ambulatory pH monitoring system and 2 days of recording in diagnosing GERD in NCCP patients. METHODS Results from ambulatory pH studies using the BRAVO™ capsule were reviewed from 62 subjects referred for evaluation of NCCP after non-diagnostic response to proton pump inhibitor therapy. Acid exposure time (AET) and symptom–reflux association tests were calculated after 1 day of recording and compared to the final outcome from the 2-day study. RESULTS Extending the recording time increased the number of subjects having elevated AET from 16 after 1 day to 22 after 2 days of recording, a 9.7% gain in subjects (95% CI 4.6–19.6%). The number of chest pain episodes doubled from 1 to 2 days, and 4 subjects (7.3%) developed symptoms only on the second day of monitoring. Statistically significant reflux–symptom association probabilities surfaced in an additional 13 subjects (21.0%; 95% CI 12.7–32.7%) by the conclusion of the 2-day study. The effect primarily was to identify significant associations in patients with lower proportions of reflux-associated symptoms. Taken together, 19.4% (95% CI 11.5–30.9%) of the subject group gained meaningful information suggesting a reflux diagnosis by extending the pH monitoring time to 2 days. CONCLUSIONS Extending monitoring to 2 days with a wireless pH monitoring system increases the detection of GERD in a clinically significant proportion of patients with NCCP." @default.
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- W1963908314 date "2006-03-01" @default.
- W1963908314 modified "2023-10-14" @default.
- W1963908314 title "Wireless pH Monitoring in Patients with Non-Cardiac Chest Pain" @default.
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- W1963908314 doi "https://doi.org/10.1111/j.1572-0241.2006.00425.x" @default.
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