Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963910088> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1963910088 endingPage "753" @default.
- W1963910088 startingPage "741" @default.
- W1963910088 abstract "We observed that culture medium conditioned with fetal rat long bones stimulated cyclic AMP production by canine renal cortical membranes. This cyclase-stimulating activity (CSA) was retained by an ultrafiltration membrane with a molecular weight cutoff of 5000; three biologically active peaks with an approximate molecular weight of 18,000-25,000, 9000-12,000, and 4000-6000 were separated by high-performance liquid chromatography. The biologic activity was destroyed by trypsin digestion. The stimulation of adenylate cyclase by the medium and by the three peaks was inhibited by [N-leu8,18,Tyr34]parathyroid hormone-(3-34)-amide and by [Tyr34]parathyroid hormone-(7-34)amide. Preincubation of the bone culture medium and of the three peaks with an antibody raised against human parathyroid hormone-(1-34) did not decrease the biologic activity more than incubation with nonimmune serum. However, the biologic activity of the three active peaks was significantly suppressed after preincubation with an antiserum directed against the N-terminal region of the parathyroid hormone-related peptide of malignancy. The release of CSA into the bone culture medium was enhanced by parathyroid hormone induction and by 1,25-dihydroxycholecalciferol. It was decreased by calcitonin. We conclude that fetal murine bones in culture release peptides that stimulate the adenylate cyclase of renal cortical membranes. These peptides are antigenically similar to the parathyroid hormone-related peptide of malignancy. Their release from bones is modulated by hormones that control bone resorption." @default.
- W1963910088 created "2016-06-24" @default.
- W1963910088 creator A5008432422 @default.
- W1963910088 creator A5013452181 @default.
- W1963910088 creator A5056824484 @default.
- W1963910088 creator A5086435192 @default.
- W1963910088 date "2009-12-03" @default.
- W1963910088 modified "2023-09-24" @default.
- W1963910088 title "Release of parathyroid hormonelike peptides by fetal rat long bones in culture" @default.
- W1963910088 cites W1607921586 @default.
- W1963910088 cites W1973192044 @default.
- W1963910088 cites W1998284470 @default.
- W1963910088 cites W2007671540 @default.
- W1963910088 cites W2034419606 @default.
- W1963910088 cites W2041669057 @default.
- W1963910088 cites W2045981686 @default.
- W1963910088 cites W2046878594 @default.
- W1963910088 cites W2054538137 @default.
- W1963910088 cites W2056739978 @default.
- W1963910088 cites W2062878660 @default.
- W1963910088 cites W2066125438 @default.
- W1963910088 cites W2077951880 @default.
- W1963910088 cites W2080993280 @default.
- W1963910088 cites W2084236074 @default.
- W1963910088 cites W2084346903 @default.
- W1963910088 cites W2086337628 @default.
- W1963910088 cites W2127554200 @default.
- W1963910088 cites W2150403092 @default.
- W1963910088 cites W2169503005 @default.
- W1963910088 doi "https://doi.org/10.1002/jbmr.5650050711" @default.
- W1963910088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2396501" @default.
- W1963910088 hasPublicationYear "2009" @default.
- W1963910088 type Work @default.
- W1963910088 sameAs 1963910088 @default.
- W1963910088 citedByCount "24" @default.
- W1963910088 countsByYear W19639100882012 @default.
- W1963910088 countsByYear W19639100882020 @default.
- W1963910088 crossrefType "journal-article" @default.
- W1963910088 hasAuthorship W1963910088A5008432422 @default.
- W1963910088 hasAuthorship W1963910088A5013452181 @default.
- W1963910088 hasAuthorship W1963910088A5056824484 @default.
- W1963910088 hasAuthorship W1963910088A5086435192 @default.
- W1963910088 hasBestOaLocation W19639100882 @default.
- W1963910088 hasConcept C116073593 @default.
- W1963910088 hasConcept C126322002 @default.
- W1963910088 hasConcept C134018914 @default.
- W1963910088 hasConcept C185592680 @default.
- W1963910088 hasConcept C202751555 @default.
- W1963910088 hasConcept C24998067 @default.
- W1963910088 hasConcept C2779627488 @default.
- W1963910088 hasConcept C2780069284 @default.
- W1963910088 hasConcept C2781208988 @default.
- W1963910088 hasConcept C519063684 @default.
- W1963910088 hasConcept C55493867 @default.
- W1963910088 hasConcept C56191518 @default.
- W1963910088 hasConcept C673006 @default.
- W1963910088 hasConcept C71315377 @default.
- W1963910088 hasConcept C71924100 @default.
- W1963910088 hasConcept C86803240 @default.
- W1963910088 hasConceptScore W1963910088C116073593 @default.
- W1963910088 hasConceptScore W1963910088C126322002 @default.
- W1963910088 hasConceptScore W1963910088C134018914 @default.
- W1963910088 hasConceptScore W1963910088C185592680 @default.
- W1963910088 hasConceptScore W1963910088C202751555 @default.
- W1963910088 hasConceptScore W1963910088C24998067 @default.
- W1963910088 hasConceptScore W1963910088C2779627488 @default.
- W1963910088 hasConceptScore W1963910088C2780069284 @default.
- W1963910088 hasConceptScore W1963910088C2781208988 @default.
- W1963910088 hasConceptScore W1963910088C519063684 @default.
- W1963910088 hasConceptScore W1963910088C55493867 @default.
- W1963910088 hasConceptScore W1963910088C56191518 @default.
- W1963910088 hasConceptScore W1963910088C673006 @default.
- W1963910088 hasConceptScore W1963910088C71315377 @default.
- W1963910088 hasConceptScore W1963910088C71924100 @default.
- W1963910088 hasConceptScore W1963910088C86803240 @default.
- W1963910088 hasIssue "7" @default.
- W1963910088 hasLocation W19639100881 @default.
- W1963910088 hasLocation W19639100882 @default.
- W1963910088 hasLocation W19639100883 @default.
- W1963910088 hasOpenAccess W1963910088 @default.
- W1963910088 hasPrimaryLocation W19639100881 @default.
- W1963910088 hasRelatedWork W1967812487 @default.
- W1963910088 hasRelatedWork W1984592800 @default.
- W1963910088 hasRelatedWork W1989056536 @default.
- W1963910088 hasRelatedWork W1990422519 @default.
- W1963910088 hasRelatedWork W2033209790 @default.
- W1963910088 hasRelatedWork W2055353584 @default.
- W1963910088 hasRelatedWork W2069096143 @default.
- W1963910088 hasRelatedWork W2082380108 @default.
- W1963910088 hasRelatedWork W2201155291 @default.
- W1963910088 hasRelatedWork W2401702418 @default.
- W1963910088 hasVolume "5" @default.
- W1963910088 isParatext "false" @default.
- W1963910088 isRetracted "false" @default.
- W1963910088 magId "1963910088" @default.
- W1963910088 workType "article" @default.