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• W1963916898 abstract "AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract When the total acid phosphatase (AP) activity of mammary carcinoma was compared with those of benign pathology and normal mammary tissue the results showed statistically significant differences (P < 0.05) when expressed per milligram of protein: 358 ± 42 nmoles per hour (mean ± standard error) in the malignant tumor, 216 ± 30 in the benign pathology, and 96 ± 45 in normal tissue and when expressed per milligram of DNA: 1858 ± 234, 1227 ± 140, 695 ± 345 nmoles per hour, respectively. The polyacrylamide gel electrophoretic profiles showed different levels of isoenzymes 3 and 4 in the three tissue groups. The appearance of isoenzyme 1 is reported after treatment of the homogenates with 5% Triton X-100. It was also found by counterimmunoelectrophoresis that the 28,000 Xg mammary tumor supernatant cross reacts with an antiserum raised against AP isoenzyme 2 although the mammary tissue does not contain such an isoenzyme. To elucidate this point, isoenzymes 1, 3 and 4 were separated by columns of Sephadex G-200 and DEAE-Sephadex. By counterimmunoelectrophoresis, it was observed that only the fraction containing isoenzyme 4 cross-reacted with the antiserum anti-AP isoenzyme 2 maintaining the catalytic activity. References 1 Yam LT. Clinical significance of the human acid phosphatases. Am J Med 1974; 56: 604– 616. 2 Lam KW, Li O, Li CY, Yam LT. Biochemical properties of human prostatic acid phosphatase. Clin Chem 1973; 19: 483– 487. 3 Gutman EB, Sproul EE, Gutman AB. Increased phosphatase activity of bone at site of osteoplastic metastases secondary to carcinoma of prostate gland. Am J Cancer 1936; 28: 485– 495. 4 Foti AG, Herschman H, Cooper JP. A solid-phase radioimmunoassay for human prostatic acid phosphatase. Cancer 1975; 35: 2446– 2452. 5 Lee C, Wang M, Murphy G, Chu TM. A solid-phase fluorescent immunoassay for human prostatic acid phosphatase. Cancer Res 1978; 38: 2871– 2878. 6 Koudstaal J, Makkink B, Overdiep SH. Enzyme histochemical patterns in human tumors: I. Hydrolytic enzymes in carcinoma of the colon and breast. Europ J Cancer Clin Oncol 1975; 11: 105– 109. 7 Machinami R. Histological grading, histochemistry, and electron microscopy of scirrhous carcinoma of the breast. Gan 1976; 67: 11– 24. 8 Bosmann B, Hall TC. Enzyme activity in invasive tumors of human breast and colon. Proc Nat Acad Sci USA 1974; 71: 1833– 1837. 9 Jegatheesan KA, Joplin GF. Correlation of serum glycolytic enzymes and acid phosphatases with sites of metastases in mammary carcinomatosis. Br Med J 1962; 1: 831– 834. 10 Tavassoli M, Rizo M, Yam LT. Elevation of serum acid phosphatase in cancer with bone metastases. Cancer 1980; 45: 2400– 2403. 11 Li CY, Yam LT, Lam WKW. Acid phosphatase isoenzymes in human leukocytes in normal and pathological conditions. J Histochem Cytochem 1970; 18: 473– 481. 12 Reisfeld RA, Lewis UJ, Williams DE. Disk electrophoresis of basic proteins and peptides on polyacrylamide gels. Nature 1962; 195: 281– 283. 13 Axline SG. Isoenzymes of acid phosphatases in normal and Calmette-Guérin Bacillus-induced rabbit alveolar macrophages. J Exp Med 1968; 128: 1031– 1047. 14 Barka T. Studies of acid phosphatase: I. Electrophoretic separation of acid phosphatases of rat liver on polyacrylamide gel. J Histochem Cytochem 1961; 9: 542– 547. 15 Babson AL, Phillips GE. An improved acid phosphatase procedure. Clin Chimica Acta 1966; 13: 264– 265. 16 Lowry OH, Rosebrough NJ, Farr AL. Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265– 275. 17 Sehneider WC. Phosphorus compounds in animal tissues. J Biol Chem 1945; 161: 293– 303. 18 Keek K. An ultramicro technique for the determination of deoxypentose nucleic acid. Arch Biochem Bioph 1956; 63: 446– 451. 19 Bramhall S. Noack N, Wu M. Loewenberg JR. A simple colorimetric method for determination of protein. Anal Biochem 1969; 31: 146– 148. 20 Hilf R, Goldenberg H, Michel I, Orlando RA, Archer FL. Enzymes, nucleic acid and lipids in human breast cancer and normal breast tissue. Cancer Res 1970; 30: 1874– 1882. 21 Yam LT, Li CY, Lam WKW. Tartrate-resistant acid phosphatase isoenzyme in the reticulum cells of leukemic reticuloendotheliosis. N Engl J Med 1971; 284: 357– 360. 22 Lam WKW, Yam LT, Wilbur HJ, Taft E, Li CY. Comparison of acid phosphatase isoenzymes of human seminal fluid, prostate and leukocytes. Clin Chem 1979; 25: 1285– 1289. 23 Tavassoli M. Rizo M, Johnson RB. Acid phosphatase activity in the cytosol fraction of the breast cancer tissue. Cancer 1981; 47: 895– 898. 24 Lafuente R. Woessner S. Sans-Sabrafen J. Isoenzymatic study of leukocytic acid phosphatase in haematologic diagnosis. Scand J. Haematol 1979; 23: 146– 160. 25 Yam LT, Janckila AJ, Li CY, Lam WK. Presence of prostatic acid phosphatase in human neutrophils. Invest Urol 1981; 19: 34– 38. 26 Li CY, Lam WKV, Yam LT. Immunohistochemical diagnosis of prostatic cancer with metastases. Cancer 1980; 46: 706– 712. Citing Literature Volume53, Issue215 January 1984Pages 301-305 ReferencesRelatedInformation" @default.
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• W1963916898 title "Acid phosphatase in human breast cancer tissue" @default.
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