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• W1963922064 abstract "On behalf of all the authors of this study, I would like to extend our appreciation for the attention that the work entitled “Toward using stable spermatozoal RNAs for prognostic assessment of male factor fertility” (1Ostermeier G.C. Goodrich R.J. Diamond M.P. Dix D.J. Krawetz S.A. Toward using stable spermatozoal RNAs for prognostic assessment of male factor fertility.Fertil Steril. 2005; 83: 1687-1694Abstract Full Text Full Text PDF PubMed Scopus (106) Google Scholar) has received. In accord with the comments of Raúl E. Piña-Aguilar, we agree that, for the first time, the use of the microarray-based diagnostic will provide a truly objective and informative assessment of male factor fertility status. The study described in Fertility and Sterility was designed to establish the status of sperm RNA integrity. It clearly showed that large-sized transcripts are preserved in mature ejaculate spermatozoa. This directly supports the notion that functional paternal transcripts are delivered at fertilization (2Ostermeier G.C. Miller D. Huntriss J.D. Diamond M.P. Krawetz S.A. Delivering spermatozoan RNA to the oocyte.Nature. 2004; 429: 154Crossref PubMed Scopus (442) Google Scholar, 3Krawetz S.A. Paternal contribution new insights and future challenges.Nature Rev Genet. 2005; 6: 633-642Crossref PubMed Scopus (296) Google Scholar). In preparation to transfer this technology from the bench to the bedside we also assessed the stability of ejaculate spermatozoal RNA. In this case the use of the Atlas Nylon Human Toxicology 1.2 Arrays was deemed appropriate as representative of a group of transcripts present in mature spermatozoa. The results obtained from the use of a more comprehensive platform describing the fingerprint of the normal fertile male have been published (4Ostermeier G.C. Dix D.G. Miller D. Khatri P. Krawetz S.A. Spermatozoal RNA profiles of normal fertile men.Lancet. 2002; 360: 773-777Abstract Full Text Full Text PDF Scopus (421) Google Scholar). Among the 27,016 unigenes present in this wider study, we interrogated 448 X chromosome unigenes and 36 Y chromosome unigenes. Minimal variation was observed among normal individuals (5Ostermeier G.C. Krawetz S.A. Spermatozoal RNAs as surrogate markers of paternal exposure.in: Burczynski M.E. Rockett J.C Surrogate tissue analysis genomic, proteomic and metabolic approaches. Taylor and Francis, Boca Raton, FL2006: 77-90Google Scholar), suggesting that this will prove a valuable assay. We are now exploring other oligonucleotide-based systems that will enable the interrogation of more than 40,000 probes for both known and candidate transcripts. This provides more than ample coverage of any transcripts that may arise from the Y chromosome or the inactivated X chromosome including the 13 that were suggested to be of interest. Again, we thank the community for their interest in this work and look forward to bringing this technology to the clinical community to assist in ascertaining the status of the male factor infertility. The future of sperm-derived mRNAsFertility and SterilityVol. 85Issue 6PreviewRecently Ostermeier et al. (1) have proposed that stable spermatozoal RNAs could be useful for male infertility prognostic and a number of male infertility factors may be identifiable using genomic profiling of spermatozoa. Full-Text PDF" @default.
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• W1963922064 title "Reply: The future of sperm-derived mRNAs" @default.
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• W1963922064 doi "https://doi.org/10.1016/j.fertnstert.2006.03.010" @default.
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