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- W1963923224 abstract "Human-bioengineered collagen implant is made from highly purified human-bioengineered collagen. It is the first FDA approved human based collagen dermal filler that does not require a skin test prior to use. The human based bioengineered Type 1 collagen used in human-bioengineered collagen implant is crosslinked with gluteraldehyde and is dispersed in phosphate buffered saline containing 0.3% lidocaine. The primary objectives of our study were to evaluate the efficacy and safety of human-bioengineered collagen implant for the correction of nasolabial folds. The secondary objective was to evaluate the longevity of human- bioengineered collagen implant for the correction of nasolabial folds. Fifteen study participants with moderately deep to well-defined deep nasolabial folds were enrolled in this open-label, pilot study. After a 2-week washout period from all topical medications to the treatment sites, study participants received human-bioengineered collagen implant injections for the correction of their nasolabial folds. The treatment sites were evaluated at week 4, week 8, week 12, week 16, and every 4 weeks until nasolabial wrinkle scores returned to baseline. At each visit, the physician performed Investigator Wrinkle Assessments and Investigator Global Assessments. In addition, study participants completed a Patient Global Assessment. Photographs were taken at each office visit. The participant photographs were reviewed and scored independently by an expert dermatologist. A blinded Independent Dermatologist Review was performed for each of the participants photographs. The study is ongoing and final results and conclusions will be presented." @default.
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- W1963923224 date "2004-03-01" @default.
- W1963923224 modified "2023-09-26" @default.
- W1963923224 title "An open label pilot study evaluating the safety and efficacy of human bioengineered collagen implant in patients undergoing cutaneous correction of nasolabial folds" @default.
- W1963923224 doi "https://doi.org/10.1016/j.jaad.2003.10.115" @default.
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