Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963925145> ?p ?o ?g. }
- W1963925145 endingPage "750" @default.
- W1963925145 startingPage "747" @default.
- W1963925145 abstract "Pretreatment of mice with the buffer tris(hydroxymethyl)aminomethane (THAM) at alkaline but not acid pH protected against effects of anemic and histotoxic hypoxia. THAM delayed the loss of the righting reflex (from 20.3 ± 0.9 to 27.4 ± 2.0 min, P < 0.01) and death (from 24 ± 4 to 32 ± 2 min, P < 0.01) in animals with anemic hypoxia (induced with NaNO2). Alkaline THAM reduced the number of animals who lost the righting reflex after the induction of histotoxic hypoxia by injection of 4 mg/kg of KCN (from 10 of 12 to 2 of 12, P < 0.01). Pretreatment with alkaline THAM also prevented the fall in acetylcholine levels and the rise in cyclic GMP induced by anemic hypoxia, and ameliorated the reduction in the synthesis of acetylcholine from labeled precursors in anemic (NaNO2-induced) hypoxia. Although the detailed molecular mechanisms by which THAM acts remain to be clarified, these observations may have direct clinical relevance for the care of the large number of patients in whom brain dysfunction results from conditions in which the supply of oxygen to the brain is impaired but not abolished." @default.
- W1963925145 created "2016-06-24" @default.
- W1963925145 creator A5034019470 @default.
- W1963925145 creator A5044990593 @default.
- W1963925145 creator A5074569290 @default.
- W1963925145 date "1979-03-01" @default.
- W1963925145 modified "2023-09-24" @default.
- W1963925145 title "Protection by tris(hydroxymethyl)-aminomethane against behavioral and neurochemical effects of hypoxia" @default.
- W1963925145 cites W1498551439 @default.
- W1963925145 cites W1967974494 @default.
- W1963925145 cites W1970961139 @default.
- W1963925145 cites W1980044641 @default.
- W1963925145 cites W1983550147 @default.
- W1963925145 cites W2004529130 @default.
- W1963925145 cites W2010120109 @default.
- W1963925145 cites W2011782508 @default.
- W1963925145 cites W2016471135 @default.
- W1963925145 cites W2022689287 @default.
- W1963925145 cites W2025295946 @default.
- W1963925145 cites W2030156003 @default.
- W1963925145 cites W2031565400 @default.
- W1963925145 cites W2036347524 @default.
- W1963925145 cites W2045192759 @default.
- W1963925145 cites W2051070212 @default.
- W1963925145 cites W2058230204 @default.
- W1963925145 cites W2058927263 @default.
- W1963925145 cites W2061614450 @default.
- W1963925145 cites W2073441246 @default.
- W1963925145 cites W2104227586 @default.
- W1963925145 cites W2105705623 @default.
- W1963925145 cites W2110765139 @default.
- W1963925145 cites W2145462399 @default.
- W1963925145 cites W2154519327 @default.
- W1963925145 cites W22874719 @default.
- W1963925145 cites W2339593414 @default.
- W1963925145 cites W2344706579 @default.
- W1963925145 cites W2416653205 @default.
- W1963925145 cites W2420492357 @default.
- W1963925145 doi "https://doi.org/10.1016/0006-2952(79)90353-8" @default.
- W1963925145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/454473" @default.
- W1963925145 hasPublicationYear "1979" @default.
- W1963925145 type Work @default.
- W1963925145 sameAs 1963925145 @default.
- W1963925145 citedByCount "10" @default.
- W1963925145 crossrefType "journal-article" @default.
- W1963925145 hasAuthorship W1963925145A5034019470 @default.
- W1963925145 hasAuthorship W1963925145A5044990593 @default.
- W1963925145 hasAuthorship W1963925145A5074569290 @default.
- W1963925145 hasConcept C126322002 @default.
- W1963925145 hasConcept C131783052 @default.
- W1963925145 hasConcept C134018914 @default.
- W1963925145 hasConcept C178790620 @default.
- W1963925145 hasConcept C185592680 @default.
- W1963925145 hasConcept C25876315 @default.
- W1963925145 hasConcept C2775910092 @default.
- W1963925145 hasConcept C2780591741 @default.
- W1963925145 hasConcept C2781014771 @default.
- W1963925145 hasConcept C540031477 @default.
- W1963925145 hasConcept C55493867 @default.
- W1963925145 hasConcept C71240020 @default.
- W1963925145 hasConcept C71924100 @default.
- W1963925145 hasConcept C7836513 @default.
- W1963925145 hasConcept C83974742 @default.
- W1963925145 hasConcept C98274493 @default.
- W1963925145 hasConceptScore W1963925145C126322002 @default.
- W1963925145 hasConceptScore W1963925145C131783052 @default.
- W1963925145 hasConceptScore W1963925145C134018914 @default.
- W1963925145 hasConceptScore W1963925145C178790620 @default.
- W1963925145 hasConceptScore W1963925145C185592680 @default.
- W1963925145 hasConceptScore W1963925145C25876315 @default.
- W1963925145 hasConceptScore W1963925145C2775910092 @default.
- W1963925145 hasConceptScore W1963925145C2780591741 @default.
- W1963925145 hasConceptScore W1963925145C2781014771 @default.
- W1963925145 hasConceptScore W1963925145C540031477 @default.
- W1963925145 hasConceptScore W1963925145C55493867 @default.
- W1963925145 hasConceptScore W1963925145C71240020 @default.
- W1963925145 hasConceptScore W1963925145C71924100 @default.
- W1963925145 hasConceptScore W1963925145C7836513 @default.
- W1963925145 hasConceptScore W1963925145C83974742 @default.
- W1963925145 hasConceptScore W1963925145C98274493 @default.
- W1963925145 hasIssue "6" @default.
- W1963925145 hasLocation W19639251451 @default.
- W1963925145 hasLocation W19639251452 @default.
- W1963925145 hasOpenAccess W1963925145 @default.
- W1963925145 hasPrimaryLocation W19639251451 @default.
- W1963925145 hasRelatedWork W1963925145 @default.
- W1963925145 hasRelatedWork W1993142192 @default.
- W1963925145 hasRelatedWork W1995226963 @default.
- W1963925145 hasRelatedWork W2041377907 @default.
- W1963925145 hasRelatedWork W2075290087 @default.
- W1963925145 hasRelatedWork W2093198910 @default.
- W1963925145 hasRelatedWork W2107563524 @default.
- W1963925145 hasRelatedWork W2171454471 @default.
- W1963925145 hasRelatedWork W2221927231 @default.
- W1963925145 hasRelatedWork W3003898614 @default.
- W1963925145 hasVolume "28" @default.
- W1963925145 isParatext "false" @default.
- W1963925145 isRetracted "false" @default.