FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963925706> ?p ?o ?g. }

• W1963925706 endingPage "120" @default.
• W1963925706 startingPage "115" @default.
• W1963925706 abstract "The hepatotoxicity of rifampicin in comparison with p-aminosalicylic acid was investigated by serial estimations of serum aspartate transaminase, isocitrate dehydrogenase, and alkaline phosphatase. Both drugs were given in combination with streptomycin and isoniazid for the treatment of pulmonary tuberculosis in Britain: in all, 54 patients were studied. A high proportion of patients receiving either regimen have a transient disturbance of liver function shown by increase in the aspartate transaminase and isocitrate dehydrogenase values, but only 2 patients, both receiving p-aminosalicylic acid, developed clinical jaundice. An increase in alkaline phosphatase, showing cholestasis, was rare. L'hépatotoxicité de la rifampicine, en comparison avec l'acide p-aminosalicylique a étéétudiée par des mesures en série de l'aspartate transaminase sérique, de l'isocitrate déhydrogénase et de la phosphatase alcaline. Les 2 drogues ont ete donnees en association avec la streptomycine et l'isoniazide pour le treaement de tuberculoses pulmonaires en Grande Bretagne : 54 malades furent étudiés en tout. Une forte proportion de malades recevant l'un et l'autre régime therapeutique curent un trouble passagé de la fonstion hépatique révélé par l'augmentation des valeurs de l'aspartate transaminase et de l'isocitrate dehydrogénase, mais 2 malades seulement, tous les deux recevant de l'acide p-aminosalicylique, eurent un ictère clinique. Une augmentation de la phosphatase alcaline, témoin de cholestase, a étéx rare. Se investigó la hepatotoxicida,d de la rifampicina comparada con el ácido p-aminosalicílico por medio de estudios seriados de aspartato transaminasa síco, isocitrato dehidrogenasa y fosfatasa alcalina. Ambas drogas se dieron asociadas con estreptomicina e isoniazida para el tratamiento de tuberculosos pulmonares en Gran Bretaña; se estudiaron en total 54 pacientes. Una elevada proporción de pacientes en ambos esquemas presentaron trastornos transitorios en la función hepática, que se tradujeron en un aumento en la transaminasa y dehidrogenasa, pero sólo dos pacientes, que recibían ácido p-aminosalicilico, tuvieron ictericia. Un aumento enla fosfatasa alcalina, con colestasis, fue raro. Verglichen wird die Lebertoxizität von Rifampicin and PAS durch Serienbestimmung der Serumaspartattransaminase, der Isozitratdehydrogenase and der alkalischen Phosphatase. Beide Medikamente wurden in Kombination mut Streptomycin und Isoniazid zur Behandlung der Lungentuberkulose in Groβbritannien gegeben; insgesamt wurden 54 Patienten untersucht. Unter beiden Rigemen kam es bei einer groβen Zahl zu einem Ausdruck einer vorübergehenden Störung der Leberfunktion, während eine klinisch manifeste Gelbsucht nur bei zwei mit PAS behandelten Kranken zu beobachten war. Ein Anstieg der alkalischen Phosphatase als Hinweis auf eine Cholostase war selten." @default.
• W1963925706 created "2016-06-24" @default.
• W1963925706 creator A5048157672 @default.
• W1963925706 creator A5071209223 @default.
• W1963925706 date "1974-06-01" @default.
• W1963925706 modified "2023-09-24" @default.
• W1963925706 title "Serum enzyme changes in patients receiving antituberculosis therapy with rifampicin or p-aminosalicylic acid, plus isoniazid and streptomycin" @default.
• W1963925706 cites W1987183719 @default.
• W1963925706 cites W2069717312 @default.
• W1963925706 cites W2081568627 @default.
• W1963925706 cites W2090058314 @default.
• W1963925706 cites W2404911190 @default.
• W1963925706 cites W4244501387 @default.
• W1963925706 doi "https://doi.org/10.1016/0041-3879(74)90004-x" @default.
• W1963925706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4620296" @default.
• W1963925706 hasPublicationYear "1974" @default.
• W1963925706 type Work @default.
• W1963925706 sameAs 1963925706 @default.
• W1963925706 citedByCount "21" @default.
• W1963925706 countsByYear W19639257062017 @default.
• W1963925706 countsByYear W19639257062022 @default.
• W1963925706 crossrefType "journal-article" @default.
• W1963925706 hasAuthorship W1963925706A5048157672 @default.
• W1963925706 hasAuthorship W1963925706A5071209223 @default.
• W1963925706 hasConcept C126322002 @default.
• W1963925706 hasConcept C142724271 @default.
• W1963925706 hasConcept C160160445 @default.
• W1963925706 hasConcept C181199279 @default.
• W1963925706 hasConcept C185592680 @default.
• W1963925706 hasConcept C2775843808 @default.
• W1963925706 hasConcept C2776877979 @default.
• W1963925706 hasConcept C2776967927 @default.
• W1963925706 hasConcept C2777150147 @default.
• W1963925706 hasConcept C2778606649 @default.
• W1963925706 hasConcept C2778607973 @default.
• W1963925706 hasConcept C2779679107 @default.
• W1963925706 hasConcept C2781069245 @default.
• W1963925706 hasConcept C29456083 @default.
• W1963925706 hasConcept C2992208098 @default.
• W1963925706 hasConcept C501593827 @default.
• W1963925706 hasConcept C55493867 @default.
• W1963925706 hasConcept C71924100 @default.
• W1963925706 hasConcept C90924648 @default.
• W1963925706 hasConceptScore W1963925706C126322002 @default.
• W1963925706 hasConceptScore W1963925706C142724271 @default.
• W1963925706 hasConceptScore W1963925706C160160445 @default.
• W1963925706 hasConceptScore W1963925706C181199279 @default.
• W1963925706 hasConceptScore W1963925706C185592680 @default.
• W1963925706 hasConceptScore W1963925706C2775843808 @default.
• W1963925706 hasConceptScore W1963925706C2776877979 @default.
• W1963925706 hasConceptScore W1963925706C2776967927 @default.
• W1963925706 hasConceptScore W1963925706C2777150147 @default.
• W1963925706 hasConceptScore W1963925706C2778606649 @default.
• W1963925706 hasConceptScore W1963925706C2778607973 @default.
• W1963925706 hasConceptScore W1963925706C2779679107 @default.
• W1963925706 hasConceptScore W1963925706C2781069245 @default.
• W1963925706 hasConceptScore W1963925706C29456083 @default.
• W1963925706 hasConceptScore W1963925706C2992208098 @default.
• W1963925706 hasConceptScore W1963925706C501593827 @default.
• W1963925706 hasConceptScore W1963925706C55493867 @default.
• W1963925706 hasConceptScore W1963925706C71924100 @default.
• W1963925706 hasConceptScore W1963925706C90924648 @default.
• W1963925706 hasIssue "2" @default.
• W1963925706 hasLocation W19639257061 @default.
• W1963925706 hasLocation W19639257062 @default.
• W1963925706 hasOpenAccess W1963925706 @default.
• W1963925706 hasPrimaryLocation W19639257061 @default.
• W1963925706 hasRelatedWork W1553195087 @default.
• W1963925706 hasRelatedWork W1972787349 @default.
• W1963925706 hasRelatedWork W2051346378 @default.
• W1963925706 hasRelatedWork W2383614070 @default.
• W1963925706 hasRelatedWork W2397329703 @default.
• W1963925706 hasRelatedWork W2619523488 @default.
• W1963925706 hasRelatedWork W3030607995 @default.
• W1963925706 hasRelatedWork W3033516131 @default.
• W1963925706 hasRelatedWork W3089260488 @default.
• W1963925706 hasRelatedWork W43103311 @default.
• W1963925706 hasVolume "55" @default.
• W1963925706 isParatext "false" @default.
• W1963925706 isRetracted "false" @default.
• W1963925706 magId "1963925706" @default.
• W1963925706 workType "article" @default.