FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963928305> ?p ?o ?g. }

• W1963928305 endingPage "3765" @default.
• W1963928305 startingPage "3738" @default.
• W1963928305 abstract "The HIV-1 p6 Gag protein contains two late assembly (l-) domains that recruit proteins of the endosomal sorting complex required for transport (ESCRT) pathway to mediate membrane fission between the nascent virion and the cell membrane. It was recently demonstrated that mutation of the highly conserved Ser-40 to Phe (S40F) disturbs CA-SP1 processing, virus morphogenesis, and infectivity. It also causes the formation of filopodia-like structures, while virus release remains unaffected. Here, we show that the mutation S40F, but not the conservative mutation to Asp (S40D) or Asn (S40N), augments membrane association, K48-linked polyubiquitination, entry into the 26S proteasome, and, consequently, enhances MHC-I antigen presentation of Gag derived epitopes. Nuclear magnetic resonance (NMR) structure analyses revealed that the newly introduced Phe-40, together with Tyr-36, causes the formation of a hydrophobic patch at the C-terminal α-helix of p6, providing a molecular rationale for the enhanced membrane association of Gag observed in vitro and in HIV-1 expressing cells. The extended exposure of the S40F mutant to unidentified membrane-resident ubiquitin E3-ligases might trigger the polyubiquitination of Gag. The cumulative data support a previous model of a so far undefined property of p6, which, in addition to MA, acts as membrane targeting domain of Gag." @default.
• W1963928305 created "2016-06-24" @default.
• W1963928305 creator A5005434625 @default.
• W1963928305 creator A5008101098 @default.
• W1963928305 creator A5044071680 @default.
• W1963928305 creator A5044367093 @default.
• W1963928305 creator A5057935188 @default.
• W1963928305 creator A5067586951 @default.
• W1963928305 creator A5070199843 @default.
• W1963928305 creator A5075012306 @default.
• W1963928305 creator A5075525711 @default.
• W1963928305 creator A5081005185 @default.
• W1963928305 date "2014-10-02" @default.
• W1963928305 modified "2023-10-10" @default.
• W1963928305 title "Mutation of the Highly Conserved Ser-40 of the HIV-1 p6 Gag Protein to Phe Causes the Formation of a Hydrophobic Patch, Enhances Membrane Association, and Polyubiquitination of Gag" @default.
• W1963928305 cites W1514433785 @default.
• W1963928305 cites W1579191879 @default.
• W1963928305 cites W1590553747 @default.
• W1963928305 cites W1659719610 @default.
• W1963928305 cites W1813266103 @default.
• W1963928305 cites W1962465787 @default.
• W1963928305 cites W1968305032 @default.
• W1963928305 cites W1969067622 @default.
• W1963928305 cites W1972378799 @default.
• W1963928305 cites W1978141733 @default.
• W1963928305 cites W1980268459 @default.
• W1963928305 cites W1990322713 @default.
• W1963928305 cites W1991879937 @default.
• W1963928305 cites W1998079639 @default.
• W1963928305 cites W1999605002 @default.
• W1963928305 cites W1999634465 @default.
• W1963928305 cites W2000622245 @default.
• W1963928305 cites W2000965308 @default.
• W1963928305 cites W2001656273 @default.
• W1963928305 cites W2023420720 @default.
• W1963928305 cites W2033320393 @default.
• W1963928305 cites W2037692580 @default.
• W1963928305 cites W2044802039 @default.
• W1963928305 cites W2047809194 @default.
• W1963928305 cites W2049172498 @default.
• W1963928305 cites W2050944927 @default.
• W1963928305 cites W2051158595 @default.
• W1963928305 cites W2051858217 @default.
• W1963928305 cites W2052933818 @default.
• W1963928305 cites W2054432610 @default.
• W1963928305 cites W2056548409 @default.
• W1963928305 cites W2058986521 @default.
• W1963928305 cites W2060316418 @default.
• W1963928305 cites W2060952336 @default.
• W1963928305 cites W2063059674 @default.
• W1963928305 cites W2067665559 @default.
• W1963928305 cites W2074130602 @default.
• W1963928305 cites W2076919467 @default.
• W1963928305 cites W2084607977 @default.
• W1963928305 cites W2086253922 @default.
• W1963928305 cites W2088848851 @default.
• W1963928305 cites W2089867788 @default.
• W1963928305 cites W2095693152 @default.
• W1963928305 cites W2095898148 @default.
• W1963928305 cites W2096358172 @default.
• W1963928305 cites W2098437057 @default.
• W1963928305 cites W2100837269 @default.
• W1963928305 cites W2100880876 @default.
• W1963928305 cites W2107329104 @default.
• W1963928305 cites W2109691647 @default.
• W1963928305 cites W2110202168 @default.
• W1963928305 cites W2114088574 @default.
• W1963928305 cites W2115909676 @default.
• W1963928305 cites W2123431540 @default.
• W1963928305 cites W2125905711 @default.
• W1963928305 cites W2126176654 @default.
• W1963928305 cites W2126210405 @default.
• W1963928305 cites W2130430799 @default.
• W1963928305 cites W2130448025 @default.
• W1963928305 cites W2131601598 @default.
• W1963928305 cites W2132441784 @default.
• W1963928305 cites W2138287142 @default.
• W1963928305 cites W2138720208 @default.
• W1963928305 cites W2139103777 @default.
• W1963928305 cites W2140430371 @default.
• W1963928305 cites W2140690761 @default.
• W1963928305 cites W2140992384 @default.
• W1963928305 cites W2142614240 @default.
• W1963928305 cites W2145135253 @default.
• W1963928305 cites W2146667353 @default.
• W1963928305 cites W2152055462 @default.
• W1963928305 cites W2156586942 @default.
• W1963928305 cites W2159011164 @default.
• W1963928305 cites W2159930404 @default.
• W1963928305 cites W2167531619 @default.
• W1963928305 cites W2168701196 @default.
• W1963928305 cites W4238629934 @default.
• W1963928305 cites W4248471000 @default.
• W1963928305 cites W4313422268 @default.
• W1963928305 doi "https://doi.org/10.3390/v6103738" @default.
• W1963928305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4213559" @default.
• W1963928305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25279819" @default.
• W1963928305 hasPublicationYear "2014" @default.

• next