FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963928446> ?p ?o ?g. }

• W1963928446 endingPage "223" @default.
• W1963928446 startingPage "216" @default.
• W1963928446 abstract "Environmental substances or metabolites induce neuronal damage through oxidative stress. Environmental organic solvent metabolite, 1,2-diacetylbenzene (1,2-DAB), treated rats develop limb weakness with neuropathological damage in both the central and peripheral nervous systems. In this experiment, we examined the relevance of 1,2-DAB-induced toxicity to increased oxidative stress using human dopaminergic neuroblastoma SHSY5Y cells. 1,2-DAB (4, 16, and 32 microM) disrupted cytoskeletal integrity and caused morphological changes. 1,2-DAB significantly decreased cell viability and induced cell cycle arrest in the G(1) phase in a concentration-dependent manner. At higher concentration, it produced apoptosis. Pre-treatment of cells with the antioxidants, GSH or N-acetylcysteine (NAC), effectively blocked 1,2-DAB-mediated cytotoxicity including cell viability, and morphological changes. These results therefore suggest that oxidative stress is involved in environmental metabolite 1,2-DAB-mediated neurotoxicity and that antioxidant treatment can effectively protect the nervous system from environmental hazards." @default.
• W1963928446 created "2016-06-24" @default.
• W1963928446 creator A5006872727 @default.
• W1963928446 creator A5030253413 @default.
• W1963928446 creator A5040250492 @default.
• W1963928446 creator A5042243864 @default.
• W1963928446 creator A5048899607 @default.
• W1963928446 creator A5054492574 @default.
• W1963928446 creator A5059902260 @default.
• W1963928446 creator A5069491246 @default.
• W1963928446 creator A5070756348 @default.
• W1963928446 creator A5089434317 @default.
• W1963928446 date "2008-01-01" @default.
• W1963928446 modified "2023-10-18" @default.
• W1963928446 title "Cytotoxicity of 1,2-diacetylbenzene in human neuroblastoma SHSY5Y cells is mediated by oxidative stress" @default.
• W1963928446 cites W191950249 @default.
• W1963928446 cites W1973347528 @default.
• W1963928446 cites W1982682488 @default.
• W1963928446 cites W1984579545 @default.
• W1963928446 cites W1985617775 @default.
• W1963928446 cites W1997611783 @default.
• W1963928446 cites W2015561107 @default.
• W1963928446 cites W2022169631 @default.
• W1963928446 cites W2023303575 @default.
• W1963928446 cites W2030318822 @default.
• W1963928446 cites W2037745004 @default.
• W1963928446 cites W2041236740 @default.
• W1963928446 cites W2042347547 @default.
• W1963928446 cites W2047088065 @default.
• W1963928446 cites W2050843263 @default.
• W1963928446 cites W2062834612 @default.
• W1963928446 cites W2065178225 @default.
• W1963928446 cites W2075268562 @default.
• W1963928446 cites W2078905373 @default.
• W1963928446 cites W2081402818 @default.
• W1963928446 cites W2089527089 @default.
• W1963928446 cites W2094642873 @default.
• W1963928446 cites W2112992168 @default.
• W1963928446 cites W2127568727 @default.
• W1963928446 cites W2130924839 @default.
• W1963928446 cites W2147508731 @default.
• W1963928446 doi "https://doi.org/10.1016/j.tox.2007.10.012" @default.
• W1963928446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18063464" @default.
• W1963928446 hasPublicationYear "2008" @default.
• W1963928446 type Work @default.
• W1963928446 sameAs 1963928446 @default.
• W1963928446 citedByCount "20" @default.
• W1963928446 countsByYear W19639284462012 @default.
• W1963928446 countsByYear W19639284462015 @default.
• W1963928446 countsByYear W19639284462016 @default.
• W1963928446 countsByYear W19639284462017 @default.
• W1963928446 countsByYear W19639284462018 @default.
• W1963928446 countsByYear W19639284462019 @default.
• W1963928446 countsByYear W19639284462020 @default.
• W1963928446 countsByYear W19639284462021 @default.
• W1963928446 countsByYear W19639284462022 @default.
• W1963928446 countsByYear W19639284462023 @default.
• W1963928446 crossrefType "journal-article" @default.
• W1963928446 hasAuthorship W1963928446A5006872727 @default.
• W1963928446 hasAuthorship W1963928446A5030253413 @default.
• W1963928446 hasAuthorship W1963928446A5040250492 @default.
• W1963928446 hasAuthorship W1963928446A5042243864 @default.
• W1963928446 hasAuthorship W1963928446A5048899607 @default.
• W1963928446 hasAuthorship W1963928446A5054492574 @default.
• W1963928446 hasAuthorship W1963928446A5059902260 @default.
• W1963928446 hasAuthorship W1963928446A5069491246 @default.
• W1963928446 hasAuthorship W1963928446A5070756348 @default.
• W1963928446 hasAuthorship W1963928446A5089434317 @default.
• W1963928446 hasConcept C109316439 @default.
• W1963928446 hasConcept C178790620 @default.
• W1963928446 hasConcept C181199279 @default.
• W1963928446 hasConcept C185592680 @default.
• W1963928446 hasConcept C190283241 @default.
• W1963928446 hasConcept C202751555 @default.
• W1963928446 hasConcept C2776151105 @default.
• W1963928446 hasConcept C2776715637 @default.
• W1963928446 hasConcept C2777477808 @default.
• W1963928446 hasConcept C2778004101 @default.
• W1963928446 hasConcept C2779491297 @default.
• W1963928446 hasConcept C29730261 @default.
• W1963928446 hasConcept C31573885 @default.
• W1963928446 hasConcept C53227056 @default.
• W1963928446 hasConcept C538909803 @default.
• W1963928446 hasConcept C54355233 @default.
• W1963928446 hasConcept C55493867 @default.
• W1963928446 hasConcept C81885089 @default.
• W1963928446 hasConcept C86803240 @default.
• W1963928446 hasConcept C95444343 @default.
• W1963928446 hasConcept C98274493 @default.
• W1963928446 hasConceptScore W1963928446C109316439 @default.
• W1963928446 hasConceptScore W1963928446C178790620 @default.
• W1963928446 hasConceptScore W1963928446C181199279 @default.
• W1963928446 hasConceptScore W1963928446C185592680 @default.
• W1963928446 hasConceptScore W1963928446C190283241 @default.
• W1963928446 hasConceptScore W1963928446C202751555 @default.
• W1963928446 hasConceptScore W1963928446C2776151105 @default.
• W1963928446 hasConceptScore W1963928446C2776715637 @default.
• W1963928446 hasConceptScore W1963928446C2777477808 @default.

• next