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- W1963929345 abstract "Insertion of foreign DNA containing the E. coli gpt marker by homologous recombination in the pigeonpox virus (PPV) thymidine kinase (TK) gene and selection for the presence of this DNA in the viral genome produced unstable recombinants after 3 plaque purifications. We highlight the persistence of duplicated TK DNA sequences arising from single crossing over, due to the growth advantage of TK+ virus. Restoration of the TK function by coinsertion of the vaccinia virus TK gene led to stable TK+ recombinants arising from double crossing over." @default.
- W1963929345 created "2016-06-24" @default.
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- W1963929345 date "1993-09-01" @default.
- W1963929345 modified "2023-09-25" @default.
- W1963929345 title "Role of the TK+ phenotype in the stability of Pigeonpox virus recombinant" @default.
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- W1963929345 doi "https://doi.org/10.1007/bf01378643" @default.
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