FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963936068> ?p ?o ?g. }

• W1963936068 endingPage "377" @default.
• W1963936068 startingPage "367" @default.
• W1963936068 abstract "Nitric oxide (NO) is an important mediator in the regulation of bronchial muscle tone and airway responsiveness. We investigated the influence of exogenous NO on airway responsiveness to acetylcholine aerosols (ACH) in normal and in hyperresponsive rabbits. White New Zealand rabbits were anesthetized, intubated, and breathed room air spontaneously. Responses of respiratory parameters in ACH challenge tests were measured. In group A the influence of NO on ACH infusion-induced airway constriction was measured. Airway responses to aerosols from 0.25 to 8.0% ACH solutions in saline were measured with 150 and 300 ppm NO inhalation (groups B and C) and compared with the same animals' responses without NO. Moreover, we examined the influence of NO synthase inhibition on airway responsiveness (group D) and the modulatory effect of NO in hyperresponsive animals (group E). 300 ppm NO inhalation significantly decreased the bronchoconstrictor response to intravenously administered ACH (group A). However, the baseline value of dynamic elastance (Edyn) was only marginally lower under the influence of 300 ppm NO. During inhalation of 150 or 300 ppm NO, responses to nebulized 2.0% and less ACH solutions remained nearly unaltered. Responses to aerosols of 4.0 and 8.0% diminished significantly (groups B and C). Following 40 min of aerosolized N-nitro-L-arginine-methyl ester (L-NAME) solution (a NO synthase inhibitor, 1.2 mM) inhalation, the response of Edyn to ACH increased significantly in group D. In group E, animals inhaled 500 mg/m3 ammonium persulfate (APS), an oxidant with various industrial applications, after the first ACH challenge test (0.2, 1.0, and 2.0% ACH). After 2 h of APS exposure, the ACH-induced broncho constriction was increased significantly in the challenge test. After another 2 h of APS inhalation, the airway responsiveness to ACH was tested under the influence of 300 ppm NO. NO significantly decreased the response to ACH to almost the same level as before APS exposure. The results indicate that responses to high ACH concentrations as well as an APS-induced increase in ACH responsiveness were effectively reduced by high concentrations of inhaled NO." @default.
• W1963936068 created "2016-06-24" @default.
• W1963936068 creator A5001904280 @default.
• W1963936068 creator A5004568932 @default.
• W1963936068 creator A5068338229 @default.
• W1963936068 date "1997-11-01" @default.
• W1963936068 modified "2023-10-14" @default.
• W1963936068 title "Modulation of Airway Responsiveness to Acetylcholine by Nitric Oxide in a Rabbit Model" @default.
• W1963936068 cites W1968395684 @default.
• W1963936068 cites W1996060907 @default.
• W1963936068 cites W2011286935 @default.
• W1963936068 cites W2012438626 @default.
• W1963936068 cites W2031791611 @default.
• W1963936068 cites W2042322531 @default.
• W1963936068 cites W2058137293 @default.
• W1963936068 cites W2061246828 @default.
• W1963936068 cites W2064054202 @default.
• W1963936068 cites W2079342899 @default.
• W1963936068 cites W2088082611 @default.
• W1963936068 cites W2093216413 @default.
• W1963936068 cites W2115511584 @default.
• W1963936068 cites W2120478459 @default.
• W1963936068 cites W2128139551 @default.
• W1963936068 cites W2136955291 @default.
• W1963936068 cites W2140036859 @default.
• W1963936068 cites W2142480814 @default.
• W1963936068 cites W2516694040 @default.
• W1963936068 doi "https://doi.org/10.1007/pl00007583" @default.
• W1963936068 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7102044" @default.
• W1963936068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9330246" @default.
• W1963936068 hasPublicationYear "1997" @default.
• W1963936068 type Work @default.
• W1963936068 sameAs 1963936068 @default.
• W1963936068 citedByCount "2" @default.
• W1963936068 crossrefType "journal-article" @default.
• W1963936068 hasAuthorship W1963936068A5001904280 @default.
• W1963936068 hasAuthorship W1963936068A5004568932 @default.
• W1963936068 hasAuthorship W1963936068A5068338229 @default.
• W1963936068 hasBestOaLocation W19639360681 @default.
• W1963936068 hasConcept C105922876 @default.
• W1963936068 hasConcept C126322002 @default.
• W1963936068 hasConcept C134018914 @default.
• W1963936068 hasConcept C185592680 @default.
• W1963936068 hasConcept C2775910092 @default.
• W1963936068 hasConcept C2776954882 @default.
• W1963936068 hasConcept C2777397205 @default.
• W1963936068 hasConcept C2777622882 @default.
• W1963936068 hasConcept C2780769369 @default.
• W1963936068 hasConcept C33362165 @default.
• W1963936068 hasConcept C42219234 @default.
• W1963936068 hasConcept C519581460 @default.
• W1963936068 hasConcept C534529494 @default.
• W1963936068 hasConcept C71924100 @default.
• W1963936068 hasConceptScore W1963936068C105922876 @default.
• W1963936068 hasConceptScore W1963936068C126322002 @default.
• W1963936068 hasConceptScore W1963936068C134018914 @default.
• W1963936068 hasConceptScore W1963936068C185592680 @default.
• W1963936068 hasConceptScore W1963936068C2775910092 @default.
• W1963936068 hasConceptScore W1963936068C2776954882 @default.
• W1963936068 hasConceptScore W1963936068C2777397205 @default.
• W1963936068 hasConceptScore W1963936068C2777622882 @default.
• W1963936068 hasConceptScore W1963936068C2780769369 @default.
• W1963936068 hasConceptScore W1963936068C33362165 @default.
• W1963936068 hasConceptScore W1963936068C42219234 @default.
• W1963936068 hasConceptScore W1963936068C519581460 @default.
• W1963936068 hasConceptScore W1963936068C534529494 @default.
• W1963936068 hasConceptScore W1963936068C71924100 @default.
• W1963936068 hasIssue "6" @default.
• W1963936068 hasLocation W19639360681 @default.
• W1963936068 hasLocation W19639360682 @default.
• W1963936068 hasLocation W19639360683 @default.
• W1963936068 hasLocation W19639360684 @default.
• W1963936068 hasOpenAccess W1963936068 @default.
• W1963936068 hasPrimaryLocation W19639360681 @default.
• W1963936068 hasRelatedWork W1963936068 @default.
• W1963936068 hasRelatedWork W1969860860 @default.
• W1963936068 hasRelatedWork W2015153374 @default.
• W1963936068 hasRelatedWork W2083331353 @default.
• W1963936068 hasRelatedWork W2099212454 @default.
• W1963936068 hasRelatedWork W2171389583 @default.
• W1963936068 hasRelatedWork W2317885422 @default.
• W1963936068 hasRelatedWork W2412313190 @default.
• W1963936068 hasRelatedWork W2414095837 @default.
• W1963936068 hasRelatedWork W2418944066 @default.
• W1963936068 hasVolume "175" @default.
• W1963936068 isParatext "false" @default.
• W1963936068 isRetracted "false" @default.
• W1963936068 magId "1963936068" @default.
• W1963936068 workType "article" @default.