FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963937129> ?p ?o ?g. }

• W1963937129 abstract "Abstract Background The bacterial Lsm protein, Hfq, is an RNA chaperone involved in many reactions related to RNA metabolism, such as replication and stability, control of small RNA activity and polyadenylation. Despite this wide spectrum of known functions, the global role of Hfq is almost certainly undervalued; its capacity to bind DNA and to interact with many other proteins are only now beginning to be taken into account. Results The role of Hfq in the maturation and degradation of the rpsO mRNA of E. coli was investigated in vivo . The data revealed a decrease in rpsO mRNA abundance concomitant to an increase in its stability when Hfq is absent. This indicates that the change in mRNA levels in hfq mutants does not result from its modification of RNA stability. Moreover, a series of independent experiments have revealed that the decrease in mRNA level is not a consequence of a reduction of translation efficiency and that Hfq is not directly implicated in translational control of rpsO expression. Reduced steady-state mRNA levels in the absence of Hfq were also shown for rpsT, rpsB and rpsB-tsf , but not for lpp, pnp or tRNA transcripts. The abundance of chimeric transcripts rpsO-lacZ and rpsB-lacZ , whose expression was driven by rpsO and rpsB promoters, respectively, was also lower in the hfq null-mutants, while the β-galactosidase yield remained about the same as in the parent wild-type strain. Conclusions The data obtained suggest that alteration of rpsO, rpsT and rpsB-tsf transcript levels observed under conditions of Hfq deficiency is not caused by the post-transcriptional events, such as mRNA destabilization or changes in translation control, and may rather result from changes in transcriptional activity. So far, how Hfq affects transcription remains unclear. We propose that one of the likely mechanisms of Hfq-mediated modulation of transcription might operate early in the elongation step, when interaction of Hfq with a nascent transcript would help to overcome transcription pauses and to prevent preliminary transcript release." @default.
• W1963937129 created "2016-06-24" @default.
• W1963937129 creator A5023940052 @default.
• W1963937129 creator A5032916783 @default.
• W1963937129 creator A5065804944 @default.
• W1963937129 creator A5091412861 @default.
• W1963937129 date "2010-02-18" @default.
• W1963937129 modified "2023-10-06" @default.
• W1963937129 title "Hfq affects mRNA levels independently of degradation" @default.
• W1963937129 cites W1571614574 @default.
• W1963937129 cites W1577561851 @default.
• W1963937129 cites W1787034942 @default.
• W1963937129 cites W1827772617 @default.
• W1963937129 cites W1845702142 @default.
• W1963937129 cites W1888434813 @default.
• W1963937129 cites W1915742247 @default.
• W1963937129 cites W1939409359 @default.
• W1963937129 cites W1970950317 @default.
• W1963937129 cites W1976218701 @default.
• W1963937129 cites W1980374979 @default.
• W1963937129 cites W1986385237 @default.
• W1963937129 cites W1989781175 @default.
• W1963937129 cites W1995250372 @default.
• W1963937129 cites W1998137451 @default.
• W1963937129 cites W1999447361 @default.
• W1963937129 cites W2001055805 @default.
• W1963937129 cites W2003740885 @default.
• W1963937129 cites W2005318857 @default.
• W1963937129 cites W2009570617 @default.
• W1963937129 cites W2010577059 @default.
• W1963937129 cites W2015483929 @default.
• W1963937129 cites W2016780222 @default.
• W1963937129 cites W2020922766 @default.
• W1963937129 cites W2027547811 @default.
• W1963937129 cites W2030976361 @default.
• W1963937129 cites W2034857418 @default.
• W1963937129 cites W2038818905 @default.
• W1963937129 cites W2041088150 @default.
• W1963937129 cites W2047259676 @default.
• W1963937129 cites W2049737239 @default.
• W1963937129 cites W2051835480 @default.
• W1963937129 cites W2053620427 @default.
• W1963937129 cites W2059705484 @default.
• W1963937129 cites W2063693474 @default.
• W1963937129 cites W2078358905 @default.
• W1963937129 cites W2079403016 @default.
• W1963937129 cites W2087903802 @default.
• W1963937129 cites W2093748687 @default.
• W1963937129 cites W2098224454 @default.
• W1963937129 cites W2098415440 @default.
• W1963937129 cites W2099940763 @default.
• W1963937129 cites W2101322984 @default.
• W1963937129 cites W2101597297 @default.
• W1963937129 cites W2102361423 @default.
• W1963937129 cites W2104966541 @default.
• W1963937129 cites W2105495135 @default.
• W1963937129 cites W2108900729 @default.
• W1963937129 cites W2120227955 @default.
• W1963937129 cites W2129870891 @default.
• W1963937129 cites W2141653906 @default.
• W1963937129 cites W2141873437 @default.
• W1963937129 cites W2150264499 @default.
• W1963937129 cites W2167987107 @default.
• W1963937129 cites W2168909239 @default.
• W1963937129 cites W2169568690 @default.
• W1963937129 cites W2297876998 @default.
• W1963937129 cites W26808849 @default.
• W1963937129 doi "https://doi.org/10.1186/1471-2199-11-17" @default.
• W1963937129 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2834685" @default.
• W1963937129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20167073" @default.
• W1963937129 hasPublicationYear "2010" @default.
• W1963937129 type Work @default.
• W1963937129 sameAs 1963937129 @default.
• W1963937129 citedByCount "52" @default.
• W1963937129 countsByYear W19639371292012 @default.
• W1963937129 countsByYear W19639371292013 @default.
• W1963937129 countsByYear W19639371292014 @default.
• W1963937129 countsByYear W19639371292015 @default.
• W1963937129 countsByYear W19639371292016 @default.
• W1963937129 countsByYear W19639371292017 @default.
• W1963937129 countsByYear W19639371292018 @default.
• W1963937129 countsByYear W19639371292019 @default.
• W1963937129 countsByYear W19639371292020 @default.
• W1963937129 countsByYear W19639371292021 @default.
• W1963937129 countsByYear W19639371292022 @default.
• W1963937129 crossrefType "journal-article" @default.
• W1963937129 hasAuthorship W1963937129A5023940052 @default.
• W1963937129 hasAuthorship W1963937129A5032916783 @default.
• W1963937129 hasAuthorship W1963937129A5065804944 @default.
• W1963937129 hasAuthorship W1963937129A5091412861 @default.
• W1963937129 hasBestOaLocation W19639371291 @default.
• W1963937129 hasConcept C104317684 @default.
• W1963937129 hasConcept C105580179 @default.
• W1963937129 hasConcept C142575336 @default.
• W1963937129 hasConcept C143065580 @default.
• W1963937129 hasConcept C149364088 @default.
• W1963937129 hasConcept C150194340 @default.
• W1963937129 hasConcept C153911025 @default.
• W1963937129 hasConcept C2775992057 @default.
• W1963937129 hasConcept C39685955 @default.

• next