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- W1963940981 abstract "The introduction of typical antipsychotics over six decades ago signaled an important milestone in psychiatry. However, second-generation antipsychotics ameliorated the positive symptoms of schizophrenia but displayed limited effectiveness for the negative and cognitive symptoms. In addition, while the newer antipsychotics produced fewer motor side effects, the atypical antipsychotics still induced weight gain and endocrinopathies. In recent years, a third generation of antipsychotics was identified. Aripiprazole was the first approved drug acting as a D 2 partial agonist/functionally selective ligand. This review presents the state of the development of novel antipsychotic dopaminergic and non-dopaminergic agents, supported by an overview of the compounds evaluated under advanced preclinical and clinical development (e.g., cariprazine and brexpiprazole). In line with the recent trends in the development of modern atypical antipsychotics, we present our strategic development of long-chain arylpiperazine-derived quinoline- and isoquinoline-sulfonamide displaying a multireceptor binding profile and partial D 2 receptor agonism." @default.
- W1963940981 created "2016-06-24" @default.
- W1963940981 creator A5025399512 @default.
- W1963940981 creator A5042157510 @default.
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- W1963940981 creator A5048295093 @default.
- W1963940981 creator A5058388777 @default.
- W1963940981 creator A5060987539 @default.
- W1963940981 date "2014-01-01" @default.
- W1963940981 modified "2023-10-16" @default.
- W1963940981 title "Quinoline- and isoquinoline-sulfonamide analogs of aripiprazole: novel antipsychotic agents?" @default.
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