Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963948735> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1963948735 abstract "One of the long-term consequences of estrogen deficiency in postmenopausal women is an increased risk of osteoporosis. Fractures of the hip and lumbar spine are associated with considerable morbidity and mortality. Estrogen replacement therapy reduces the risk of osteoporosis, but there is no clear agreement on the most appropriate doses to be used. The aim of this study was to compare changes in bone mineral density (BMD) measurements using conventional and lower dose estradiol.A prospective, randomized, placebo-controlled 12-month study of the effect of 1 and 2 mg estradiol on BMD in 152 hysterectomized postmenopausal Chinese women with no contraindication to the use of estrogen replacement therapy.Over 12 months, spinal BMD in placebo treated patients decreased by a mean of 2% from baseline (-0.02+/-0.03 g/cm(2)) while it increased by 2% in the 1 mg (0.02+/-0.03 g/cm(2)) and 3% in the 2 mg group (0.03+/-0.03 g/cm(2)). Mean changes in BMD over 12 months in the hip were -0.02+/-0.02 g/cm(2) (-2%), 0.01+/-0.02 g/cm(2) (+1%) and 0.01+/-0.03 g/cm(2) (+1%) in the placebo, 1 and 2 mg estradiol groups, respectively (P<0.05). Relative to placebo, increases in BMD in both 1 and 2 mg groups were statistically significant for both spine and hip (P<0.05). However, there was no significant difference in the increase in BMD between the 1 and 2 mg doses for either lumbar spine or hip (P=0.82, 0.53, respectively).The results of our study show that a 1 mg dose of oral estradiol is effective in preventing bone loss in postmenopausal Chinese women." @default.
- W1963948735 created "2016-06-24" @default.
- W1963948735 creator A5015120147 @default.
- W1963948735 creator A5019964735 @default.
- W1963948735 creator A5021354185 @default.
- W1963948735 creator A5035372594 @default.
- W1963948735 creator A5035856264 @default.
- W1963948735 creator A5057939045 @default.
- W1963948735 creator A5077281500 @default.
- W1963948735 creator A5078845358 @default.
- W1963948735 date "2003-07-01" @default.
- W1963948735 modified "2023-09-27" @default.
- W1963948735 title "A prospective, randomized, placebo-controlled study of the dose effect of oral estradiol on bone mineral density in postmenopausal Chinese women" @default.
- W1963948735 cites W1503534493 @default.
- W1963948735 cites W1998992269 @default.
- W1963948735 cites W2004302812 @default.
- W1963948735 cites W2022187355 @default.
- W1963948735 cites W2028655493 @default.
- W1963948735 cites W2030491751 @default.
- W1963948735 cites W2041250016 @default.
- W1963948735 cites W2134137902 @default.
- W1963948735 cites W2144238512 @default.
- W1963948735 cites W44375275 @default.
- W1963948735 doi "https://doi.org/10.1016/s0378-5122(03)00157-9" @default.
- W1963948735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12818461" @default.
- W1963948735 hasPublicationYear "2003" @default.
- W1963948735 type Work @default.
- W1963948735 sameAs 1963948735 @default.
- W1963948735 citedByCount "5" @default.
- W1963948735 countsByYear W19639487352019 @default.
- W1963948735 crossrefType "journal-article" @default.
- W1963948735 hasAuthorship W1963948735A5015120147 @default.
- W1963948735 hasAuthorship W1963948735A5019964735 @default.
- W1963948735 hasAuthorship W1963948735A5021354185 @default.
- W1963948735 hasAuthorship W1963948735A5035372594 @default.
- W1963948735 hasAuthorship W1963948735A5035856264 @default.
- W1963948735 hasAuthorship W1963948735A5057939045 @default.
- W1963948735 hasAuthorship W1963948735A5077281500 @default.
- W1963948735 hasAuthorship W1963948735A5078845358 @default.
- W1963948735 hasConcept C126322002 @default.
- W1963948735 hasConcept C126894567 @default.
- W1963948735 hasConcept C142724271 @default.
- W1963948735 hasConcept C168563851 @default.
- W1963948735 hasConcept C204787440 @default.
- W1963948735 hasConcept C27081682 @default.
- W1963948735 hasConcept C2776494729 @default.
- W1963948735 hasConcept C2776541429 @default.
- W1963948735 hasConcept C2776886416 @default.
- W1963948735 hasConcept C2777164284 @default.
- W1963948735 hasConcept C2778562196 @default.
- W1963948735 hasConcept C2779279991 @default.
- W1963948735 hasConcept C2779329777 @default.
- W1963948735 hasConcept C2780159708 @default.
- W1963948735 hasConcept C71924100 @default.
- W1963948735 hasConceptScore W1963948735C126322002 @default.
- W1963948735 hasConceptScore W1963948735C126894567 @default.
- W1963948735 hasConceptScore W1963948735C142724271 @default.
- W1963948735 hasConceptScore W1963948735C168563851 @default.
- W1963948735 hasConceptScore W1963948735C204787440 @default.
- W1963948735 hasConceptScore W1963948735C27081682 @default.
- W1963948735 hasConceptScore W1963948735C2776494729 @default.
- W1963948735 hasConceptScore W1963948735C2776541429 @default.
- W1963948735 hasConceptScore W1963948735C2776886416 @default.
- W1963948735 hasConceptScore W1963948735C2777164284 @default.
- W1963948735 hasConceptScore W1963948735C2778562196 @default.
- W1963948735 hasConceptScore W1963948735C2779279991 @default.
- W1963948735 hasConceptScore W1963948735C2779329777 @default.
- W1963948735 hasConceptScore W1963948735C2780159708 @default.
- W1963948735 hasConceptScore W1963948735C71924100 @default.
- W1963948735 hasLocation W19639487351 @default.
- W1963948735 hasLocation W19639487352 @default.
- W1963948735 hasOpenAccess W1963948735 @default.
- W1963948735 hasPrimaryLocation W19639487351 @default.
- W1963948735 hasRelatedWork W1973882242 @default.
- W1963948735 hasRelatedWork W1980530104 @default.
- W1963948735 hasRelatedWork W1983632360 @default.
- W1963948735 hasRelatedWork W2018583822 @default.
- W1963948735 hasRelatedWork W2057743957 @default.
- W1963948735 hasRelatedWork W2321782678 @default.
- W1963948735 hasRelatedWork W2400578820 @default.
- W1963948735 hasRelatedWork W2410255862 @default.
- W1963948735 hasRelatedWork W3028806466 @default.
- W1963948735 hasRelatedWork W4292258670 @default.
- W1963948735 isParatext "false" @default.
- W1963948735 isRetracted "false" @default.
- W1963948735 magId "1963948735" @default.
- W1963948735 workType "article" @default.